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Chinese medicinal compound effective component for treating gynecological diseases and preparation method and application thereof

A technology for gynecological diseases and effective parts, which is applied to the effective parts of traditional Chinese medicine compound and its preparation, and the application field of preparation of drugs for treating gynecological diseases. It can solve the problems of unclear material basis for curative effect, unclear effective parts, and large dosage. , to achieve the effect of convenient clinical use, no adverse reactions, and clear active ingredients

Inactive Publication Date: 2010-09-15
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing patents for gynecological diseases only protect the compatibility of compound prescriptions (such as CN 136871A, a traditional Chinese medicine compound; CN1895458A, an important compound extract for treating gynecological diseases and its preparation method); Research on active ingredients (such as CN1651033A, a traditional Chinese medicine compound for treating gynecological diseases and its preparation method; CN1470273A, a medicine for treating gynecological diseases and its application preparation; CN1530126A, a pharmaceutical composition, its preparation method and its application in the preparation of medicines for treating gynecological diseases Chinese medicine has a long history of treating gynecological diseases. It has unique therapeutic advantages. However, most of the compound drugs for gynecological diseases are inconvenient to use, large in dosage, complex in composition, and unclear in effective parts. Therefore, it is very necessary to develop a drug for the treatment of gynecological diseases with clear effective substances, definite curative effect, small side effects and convenient taking under the guidance of the theory of traditional Chinese medicine.

Method used

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  • Chinese medicinal compound effective component for treating gynecological diseases and preparation method and application thereof
  • Chinese medicinal compound effective component for treating gynecological diseases and preparation method and application thereof
  • Chinese medicinal compound effective component for treating gynecological diseases and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A method for the effective part of a traditional Chinese medicine compound with the effect of treating gynecological diseases, the preparation method of which is:

[0036] (1) Weigh 10 parts of Angelica sinensis, 3 parts of Chuanxiong, 8 parts of Radix Paeoniae Rubra, 10 parts of Puhuang, 8 parts of Wulingzhi, 5 parts of Myrrha, and 5 parts of Corydalis Corydalis in proportion, and grind them to a particle size of 40 mesh , mix, decoct and extract twice with water, add 10 times the amount of medicinal materials for the first time and decoct for 1.5 hours, add 8 times the amount of medicinal materials for the second time and decoct for 1 hour, combine the two times of decoction, and concentrate to 1g crude drug / ml, get concentrated solution;

[0037] (2) Use 95% ethanol to adjust the concentrated solution obtained in step (1) to an ethanol concentration of 80%, leave it for 12 hours, filter the precipitate, take the supernatant, concentrate to 5kg, and obtain the concen...

Embodiment 2

[0041] A method for the effective part of a traditional Chinese medicine compound with the effect of treating gynecological diseases, the preparation method of which is:

[0042] (1) Take a traditional Chinese medicine compound consisting of 30 parts of Angelica sinensis, 10 parts of Chuanxiong, 15 parts of Radix Paeoniae Rubra, 50 parts of Puhuang, 15 parts of Wulingzhi, 10 parts of Myrrha, and 10 parts of Corydalis Corydalis, mix and grind until the particle size is 40 mesh, reflux extraction with 30% ethanol for 3 times, add 8 times the amount of 30% ethanol for the first time and reflux for 2 hours, add 6 times the amount of 30% ethanol for the second time and reflux for 2 hours, add 6 times the amount of 30% ethanol for the third time Reflux for 1.5h, combine the extracts, and concentrate under reduced pressure at 50-70°C to obtain 6kg of concentrate;

[0043] (2) Add ethanol to the concentrated solution obtained in step (1) to make the concentration of ethanol reach 70%,...

Embodiment 3

[0048] A method for the effective part of a traditional Chinese medicine compound with the effect of treating gynecological diseases, the preparation method of which is:

[0049] (1) Take a traditional Chinese medicine compound consisting of 50 parts of Angelica sinensis, 20 parts of Rhizoma Chuanxiong, 25 parts of Radix Paeoniae Rubra, 50 parts of Puhuang, 20 parts of Wulingzhi, 10 parts of Myrrha, and 10 parts of Corydalis Corydalis, mix and grind until the particle size is 40 mesh, reflux extraction with 70% ethanol for 2 times, add 10 times the amount of 70% ethanol for the first time, reflux for 2 hours, add 8 times the amount of 70% ethanol for the second time, reflux for 1.5 hours, combine the extracts, and store at 50-70°C Concentrate under reduced pressure to obtain 7 kg of concentrated solution;

[0050] (2) Add ethanol to the concentrated solution obtained in step (1) to make the concentration of ethanol reach 90%, place the precipitate, separate the supernatant, an...

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Abstract

The invention discloses a Chinese medicinal compound effective component for treating gynecological diseases and a preparation method and application thereof. The effective component is prepared by obtaining water or ethanol extract of a Chinese medicinal compound consisting of Chinese angelica, Szechuan lovage rhizome, red paeony root, cattail pollen, trogopterus dung, myrrh and corydalis tuber, removing impurity through ethanol precipitation, then injecting the extract into a macroporous absorption resin column, and purifying the extract by gradient elution of ethanol with optimized concentration. A compatible raw material formula is selected according to the Chinese medicinal theory and the gynecological disease pathogenesis; modern analysis instruments and pharmacological experiments show that the Chinese medicinal compound effective component provided by the invention has good activities of resisting uterine smooth muscle spasm, easing pain, resisting inflammation, adjusting estrogen and progestational hormone level, adjusting immunity and the like, can be used for treating multiple gynecological diseases such as primary dysmenorrhea, endometriosis, acute and chronic pelvic inflammation and the like, has clearer components and lower adverse reaction, and is expected to be developed as a new generation medicament for treating the gynecological diseases.

Description

technical field [0001] The invention relates to an effective part of a compound traditional Chinese medicine, in particular to an effective part of a compound traditional Chinese medicine capable of treating gynecological diseases, a preparation method thereof, and an application thereof in preparing medicines for treating gynecological diseases. Background technique [0002] Gynecological diseases are common and frequently-occurring diseases of women, most of which are closely related to inflammation and endocrine disorders. In gynecological inflammation, the incidence of chronic pelvic inflammatory disease, chronic cervicitis, and vaginitis is relatively high; in gynecological endocrine disorders, menstrual disorders are usually the main manifestation, and whether menstruation is normal or not depends on the level of sex steroid hormones. Regular menstruation is formed under the fluctuation of menstruation. [0003] Epidemiological studies have shown that dysmenorrhea is ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P15/00A61K35/24
Inventor 宿树兰段金廒钱大玮华永庆洪敏周卫
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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