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Gatifloxacin molecularly imprinted polymer adsorbent and preparation process thereof

A high molecular polymer, gatifloxacin technology, applied in other chemical processes, chemical instruments and methods, etc.

Inactive Publication Date: 2010-09-15
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the enrichment of gatifloxacin antibiotic residues using molecularly imprinted polymers has not been reported yet.

Method used

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  • Gatifloxacin molecularly imprinted polymer adsorbent and preparation process thereof
  • Gatifloxacin molecularly imprinted polymer adsorbent and preparation process thereof
  • Gatifloxacin molecularly imprinted polymer adsorbent and preparation process thereof

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Effect test

Embodiment 1

[0007] Gatifloxacin is used as template molecule, acetonitrile is used as solvent, methacrylic acid is used as functional monomer, ethylene glycol dimethacrylate is used as crosslinking agent, azobisisobutyronitrile is used as initiator, template molecule: functional monomer : The molar ratio of crosslinking agent: initiator is 1:4:20:0.2 (molar ratio), thermally initiated polymerization at 60°C to form a molecularly imprinted microsphere polymer (about 100nm), this polymer has obvious specific adsorption properties .

Embodiment 2

[0009] With gatifloxacin as the template molecule, chloroform as the solvent, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the crosslinking agent, and azobisisobutyronitrile as the initiator, the template molecule: function The molar ratio of monomer:crosslinking agent:initiator is 1:4:20:0.2 (molar ratio), thermally initiated polymerization at 60°C to form molecularly imprinted microsphere polymer (about 100nm), this polymer has obvious specificity Adsorption performance, the maximum adsorption capacity is 246umol / g.

Embodiment 3

[0011] Gatifloxacin is used as template molecule, acetonitrile is used as solvent, methacrylic acid is used as functional monomer, ethylene glycol dimethacrylate is used as crosslinking agent, azobisisobutyronitrile is used as initiator, template molecule: functional monomer : The molar ratio of crosslinking agent: initiator is 1:4:20:0.6 (molar ratio), thermally initiated polymerization at 60°C to form a molecularly imprinted microsphere polymer (about 100nm), this polymer has obvious specific adsorption properties .

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Abstract

The invention discloses a gatifloxacin molecularly imprinted polymer adsorbent and preparation process thereof. The invention relates to an organic polymer compound, and aims to provide a gatifloxacin molecularly imprinted polymer adsorbent having good selectivity and adsorbability to the gatifloxacin, and preparation process thereof. The technical scheme of the invention is as follows: the gatifloxacin, methylacrylic acid, ethylene glycol dimethacrylate and azodiisobutyronitrile are subject to thermalpolymerization to generate porous spherical high polymer of which the specific surface area is not less than 90m<2> / g. The invention provides the process of the gatifloxacin molecularly imprinted polymer adsorbent described in preparation claim 1, the gatifloxacin, methylacrylic acid, ethylene glycol dimethacrylate and azodiisobutyronitrile are placed in the solvent of acetonitrile or trichloromethane at 50-70 DEG C to thermally initiate the gatifloxacin molecularly imprinted polymer adsorbent. The invention is used for detecting the content of the gatifloxacin.

Description

Technical field: [0001] The invention relates to an organic polymer compound, in particular to a gatifloxacin molecularly imprinted polymer adsorbent and a preparation process thereof. Background technique: [0002] With the intensive development of animal husbandry, veterinary drug antibiotics are playing an increasingly important role in controlling infectious diseases of livestock and poultry. The extensive use of antibiotics in veterinary medicines and the abuse of exceeding the standard and without indicators have brought greater economic benefits to the animal husbandry industry, but at the same time it has also led to multiple negative effects, such as antibiotics in meat, eggs, poultry, and dairy foods exceeding the standard , which not only affects the export quality of livestock products, but also causes great economic losses to the breeding industry. At the same time, it also brings serious antibiotic pollution to the breeding water and soil, which affects the liv...

Claims

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Application Information

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IPC IPC(8): B01J20/285B01J20/30
Inventor 樊静高燕哺朱桂芬金彩霞苏现伐王建玲鲍林林王海波谢志广
Owner HENAN NORMAL UNIV
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