Magnetic phase-change microcapsule for performing thermal protection on normal structure in thermal physical therapy
A magnetic phase transition and microcapsule technology, which is applied to cooling appliances for therapeutic treatment, heating appliances for therapeutic treatment, treatment, etc., can solve the problems of limited surface thermal protection depth, limited thermal protection, poor tissue thermal conductivity, etc. To achieve the effect of simple and feasible treatment method, improved thermal protection strength, and enhanced biocompatibility
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Embodiment 1
[0022] Depend on figure 1 and 2 It can be seen that in this embodiment, the phase change material 1 selects a solid-liquid phase transition material with a phase transition temperature of 38-100°C in the hyperthermia process, and a liquid phase transition temperature of -100-0°C in tumor cryotherapy. Materials with a solid phase transition. Magnetic particle 2 selects magnetic micro / nanoparticle or magnetotactic bacteria, and described magnetic phase change microcapsule 4 is to embed phase change material 1 and magnetic particle 2 in liposome by methods such as film method, reverse evaporation method and ultrasonic method Inside the shell 3. Before single thermal physical therapy such as hyperthermia, cold therapy or cryosurgery, the magnetic phase-change microcapsules 4 are injected through veins, arterial catheters, subcutaneous injections and direct injections, and the magnetic phase-change microcapsules 4 are aggregated under the action of an external electromagnetic fie...
Embodiment 2
[0024] Depend on image 3 It can be seen that, except that the phase change material 1 of the present invention adopts the above-mentioned single phase change material according to thermal physical processes such as hyperthermia, cold therapy or cryosurgery, two or more phase change temperatures of two or more phase change temperatures can also be selected. Material combination. For example, two phase change materials with phase transition temperatures of 42°C and 60°C are selected to be combined into phase change material 1 to protect normal tissue 6 during hyperthermia, and a similar combination of phase change material 1 can also be used in cryosurgery. In the process of alternation of cold and heat therapy, two or more materials with solid-liquid phase transition temperature at 38-100°C and materials with liquid-solid phase transition at -100-0°C can be selected, respectively. Normal tissue 6 is protected from heat during heat therapy and cold therapy. The embedding meth...
Embodiment 3
[0026] Depend on Figure 4 It can be seen that the magnetic phase-change microcapsule 4 of the present invention can also first embed the phase-change material 1 in the liposome shell 3 by methods such as thin film method, reverse evaporation method and ultrasonic method, and then connect with the magnetic particle 2, wherein the phase change The change material 1 is a single phase change material. For example, the magnetic particle 2 selects the magnetotactic bacteria, and the special protein on the magnetotactic bacteria is chemically cross-linked with the liposome shell 3 embedding the phase change material 1 .
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