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Magnetic phase-change microcapsule for performing thermal protection on normal structure in thermal physical therapy

A magnetic phase transition and microcapsule technology, which is applied to cooling appliances for therapeutic treatment, heating appliances for therapeutic treatment, treatment, etc., can solve the problems of limited surface thermal protection depth, limited thermal protection, poor tissue thermal conductivity, etc. To achieve the effect of simple and feasible treatment method, improved thermal protection strength, and enhanced biocompatibility

Inactive Publication Date: 2010-09-22
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods can play a certain role in protecting normal tissues, they are still far from achieving the desired results.
Poor tissue thermal conductivity, limited depth of surface thermal protection, limited thermal protection of normal tissue in the treatment of deep tumor diseases
The use of targeted therapy can improve the effect of tumor tissue, but it is inevitable to damage the normal tissue around the target area due to heat conduction.

Method used

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  • Magnetic phase-change microcapsule for performing thermal protection on normal structure in thermal physical therapy
  • Magnetic phase-change microcapsule for performing thermal protection on normal structure in thermal physical therapy
  • Magnetic phase-change microcapsule for performing thermal protection on normal structure in thermal physical therapy

Examples

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Effect test

Embodiment 1

[0022] Depend on figure 1 and 2 It can be seen that in this embodiment, the phase change material 1 selects a solid-liquid phase transition material with a phase transition temperature of 38-100°C in the hyperthermia process, and a liquid phase transition temperature of -100-0°C in tumor cryotherapy. Materials with a solid phase transition. Magnetic particle 2 selects magnetic micro / nanoparticle or magnetotactic bacteria, and described magnetic phase change microcapsule 4 is to embed phase change material 1 and magnetic particle 2 in liposome by methods such as film method, reverse evaporation method and ultrasonic method Inside the shell 3. Before single thermal physical therapy such as hyperthermia, cold therapy or cryosurgery, the magnetic phase-change microcapsules 4 are injected through veins, arterial catheters, subcutaneous injections and direct injections, and the magnetic phase-change microcapsules 4 are aggregated under the action of an external electromagnetic fie...

Embodiment 2

[0024] Depend on image 3 It can be seen that, except that the phase change material 1 of the present invention adopts the above-mentioned single phase change material according to thermal physical processes such as hyperthermia, cold therapy or cryosurgery, two or more phase change temperatures of two or more phase change temperatures can also be selected. Material combination. For example, two phase change materials with phase transition temperatures of 42°C and 60°C are selected to be combined into phase change material 1 to protect normal tissue 6 during hyperthermia, and a similar combination of phase change material 1 can also be used in cryosurgery. In the process of alternation of cold and heat therapy, two or more materials with solid-liquid phase transition temperature at 38-100°C and materials with liquid-solid phase transition at -100-0°C can be selected, respectively. Normal tissue 6 is protected from heat during heat therapy and cold therapy. The embedding meth...

Embodiment 3

[0026] Depend on Figure 4 It can be seen that the magnetic phase-change microcapsule 4 of the present invention can also first embed the phase-change material 1 in the liposome shell 3 by methods such as thin film method, reverse evaporation method and ultrasonic method, and then connect with the magnetic particle 2, wherein the phase change The change material 1 is a single phase change material. For example, the magnetic particle 2 selects the magnetotactic bacteria, and the special protein on the magnetotactic bacteria is chemically cross-linked with the liposome shell 3 embedding the phase change material 1 .

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Abstract

The invention discloses a magnetic phase-change microcapsule for performing thermal protection on a normal structure in thermal physical therapy. The magnetic phase-change microcapsule is a spherical microcapsule which is composed of a phase-change material (1), magnetic particles (2) and a liposome shell (3), and the mean diameter thereof is 1nm-1mm. In the invention, the phase-change material (1) is solid-liquid or / and liquid-solid phase-change material with high phase change heat and the phase change temperature at -10-0 DEG C or 38-100 DEG C according to different thermal physical therapeutic processes such as thermal therapy, cold therapy, cryosurgery or cold-heat alternating therapy and the like; the magnetic particles (2) are magnetic micro / nano-particles or magnetotactic bacteria; and a liposome is taken as a capsule carrier for lowering toxicity of the material and protecting an encapsulated material. The invention provides a safe and effective thermal protection material with novel concept. In the invention, the magnetic phase-change microcapsule can be gathered into a target organ with blood circulation under the action of an applied magnetic field; phase-change latent heat and low thermal conductivity of the phase-change material are adopted to carry out thermal protection on the normal structure; and the material is widely applied to thermal physical therapy, and the application method thereof is simple, feasible and reliable.

Description

technical field [0001] The invention relates to a magnetic phase-change microcapsule for thermal protection of normal tissues in thermal physical therapy, in particular to a magnetic phase-change microcapsule composed of magnetic particles, phase-change materials and liposome shells. Background technique [0002] Typical thermophysiotherapy includes tumor hyperthermia, cold therapy, cryosurgery and alternating cold and heat therapy, etc. Tumor hyperthermia refers to a treatment method that uses heating to increase the local temperature of the cancerous part of the human body, thereby eliminating cancer cells It has been more than 100 years since a case of soft tissue sarcoma confirmed by pathology was cured after erysipelas infection and high fever in 1886. The development of modern tumor hyperthermia biology has laid a basic biological foundation for corresponding clinical practice. Among the factors that affect the high efficacy of tumor hyperthermia, the most critical one...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/00A61N7/02A61N5/00A61B18/00
Inventor 吕永刚杨力
Owner CHONGQING UNIV
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