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Method for preparing hydroxyapatite/composite hole bioactive glass

A technology of bioactive glass and hydroxyapatite, applied in phosphorus compounds, chemical instruments and methods, inorganic chemistry, etc., can solve the problems of slow bone formation, poor mechanical properties, complicated operation, etc., achieve simple equipment and relieve pain , the effect of shortening the time of bone formation

Inactive Publication Date: 2010-09-29
HARBIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to solve the problems of poor mechanical properties, slow bone formation speed, complicated operation and high cost in the existing composite porous bioactive glass materials; and the use of coral as a transplant material also has the problem of slow bone formation speed, and provides a Preparation method of a kind of hydroxyapatite / composite pore bioactive glass

Method used

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  • Method for preparing hydroxyapatite/composite hole bioactive glass
  • Method for preparing hydroxyapatite/composite hole bioactive glass
  • Method for preparing hydroxyapatite/composite hole bioactive glass

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specific Embodiment approach 1

[0011] Specific embodiment 1: The preparation method of hydroxyapatite / composite pore bioactive glass in this embodiment is realized according to the following steps: 1. Dissolve 3 to 5 g of triblock copolymer P123 in a mixed solution of absolute ethanol and hydrochloric acid , and then sequentially add 5-7g of tetraethyl orthosilicate, 1-2g of calcium nitrate and 0.5-1g of ethyl triphosphate, and stir for 1-5h to obtain solution A; 2. Wash the coral with deionized water, and then immerse it to a concentration of 0.1~0.3mol / L NaHPO 4 -NaH 2 PO 4 5-12 hours in the buffer solution, then washed with deionized water, and dried to obtain macroporous hydroxyapatite; 3. Immerse the macroporous hydroxyapatite in solution A for 2-6 hours, take it out and dry it at room temperature, and repeat the operation Immerse and dry once, then immerse in solution A for 2-6 hours, take it out and rinse with deionized water for 3-5 times to obtain an amorphous material; 4. Put the amorphous mater...

specific Embodiment approach 2

[0017] Specific embodiment two: the difference between this embodiment and specific embodiment one is that in step one, 3g of triblock copolymer P123 is dissolved in the mixed solution of absolute ethanol and hydrochloric acid, and then sequentially add 5g of tetraethyl orthosilicate, 1g of calcium nitrate and 0.5g of ethyl triphosphate were stirred for 1h to obtain solution A. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0018] Specific embodiment three: the difference between this embodiment and specific embodiment one is that in step one, 5g of triblock copolymer P123 is dissolved in a mixed solution of absolute ethanol and hydrochloric acid, and then 7g of tetraethyl orthosilicate, 2g of calcium nitrate and 1g of ethyl triphosphate were stirred for 5 hours to obtain solution A. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The invention discloses a method for preparing hydroxyapatite / composite hole bioactive glass, relates to a method for preparing bioactive glass; and solves the problems of poor mechanical property, slow bone formation rate, complicated operation and high cost existing in the conventional composite hole bioactive glass material and the problem of low bone formation rate when coral is used as a transplanting material. The method comprises the following steps of: 1, dissolving triblock copolymer P123 in mixed solution consisting of absolute ethyl alcohol and hydrochloric acid, sequentially adding tetraethoxysilane, calcium nitrate and triethyl phosphate and stirring the mixture to obtain solution A; 2, washing the coral, immersing the washed coral in buffer solution, and washing and drying the mixture to obtain macroporous hydroxyapatite; 3, immersing the macroporous hydroxyapatite in the solution A to obtain an amorphous material; and 4, calcining the amorphous material to obtain the bioactive glass. The bone formation time of the material prepared by the method is shortened to be 12 hours; the biocompatibility and mechanical strength of the material both meet the requirements of bone repair materials; and the adopted device is simple and the raw materials have low price.

Description

technical field [0001] The invention relates to a preparation method of bioactive glass. Background technique [0002] Bioactive glass (MMBG) is one of the hotspots in the study of bone tissue repair materials. It has good bioactivity and biocompatibility. Its main components include CaO-P 2 o 5 -SiO 2 -MO (M=Na, Mg, etc.), after being implanted in the human body, through the circulation of body fluids, the bioactive glass can exchange ions with soft tissues and bones, so that chemical bonds are formed between the material interface and human bone tissue. This kind of ion exchange plays a role in mineralization, and finally forms a hydroxyapatite (HA) layer with the same mineral form as normal bone tissue, which can induce more rapid bone repair and regeneration. [0003] Therefore, bioactive glass has a higher research and application value as a scaffold for bone tissue engineering. When bone repair materials are applied to the human body, they must be in contact with ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/50A61L27/56C01B25/32C03C11/00
Inventor 曲凤玉李晓丰金英学武祥张旭
Owner HARBIN NORMAL UNIVERSITY
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