Preparation method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles
A nuclear magnetic resonance imaging and nanoparticle technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, and pharmaceutical formulations, can solve the problems of increasing safety hazards, unfavorable vascular imaging, and low relaxation rates.
A nuclear magnetic resonance imaging and nanoparticle technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, preparations for in vivo experiments, and pharmaceutical formulations, can solve the problems of increasing safety hazards, unfavorable vascular imaging, and low relaxation rates.
CN101845112AInactive Publication Date: 2010-09-29EAST CHINA UNIV OF SCI & TECH
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Abstract
The invention relates to a nuclear magnetic resonance imaging contrast agent, in particular to a method of high-flexibility nuclear magnetic resonance imaging contrast agents based on high molecular nanometer particles prepared through fine emulsion polymenrization. The nuclear magnetic resonance imaging contrast agents are prepared from the composition of 1, 4, 7, 10-tetrazo heterocycle dodecane with long-chain alkane and gadolinium (Gd-DOTA for short) or the composition of diethylenetriamine pentaacetic acid and gadolinium (Gd-DTPA for short) for carrying out fine emulsion polymenrization preparation with high molecular monomers. The Gd-DOTA derivatives (Gd-DOTA derivatives for short) with the long-chain alkane and the Gd-DTPA derivatives (Gd- DTPA derivatives for short) with the long-chain alkane respectively have the structures as the first formula and the second formula, wherein the value of n is between 8 and 24.
Description
technical field The invention relates to a nuclear magnetic resonance imaging contrast agent, in particular to a method for preparing a high-sensitivity nuclear magnetic resonance imaging contrast agent based on polymer nanoparticles by miniemulsion polymerization. Background technique Magnetic resonance imaging (MRI) technology has received unprecedented attention and application in the field of modern medical diagnosis. It can provide people with high-quality three-dimensional soft tissue imaging pictures under the condition of avoiding ion radiation. It is the main technology for disease diagnosis in the field of modern medicine. one. The signal intensity obtained by MRI mainly depends on the hydrogen nucleus density and the relaxation rate of water protons at the examination site, and the difference in hydrogen nucleus density and relaxation time between different tissues in the human body, between normal tissues and diseased tissues in the same tissue It is the main ba...
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Patent Timeline
29 Sep 2010
Publication
CN101845112A
- IPC
- C08F212/08; C08F212/36; C08F220/14; C08F220/56; C08F2/30; A61K49/12; A61K49/06
- Inventors
- 胡爱国; 陈争艳