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Enamel-shaped hydroxyapatite and preparation method and application thereof

A technology of hydroxyapatite and tooth enamel, applied in the field of biomedical materials, can solve the problems that tooth enamel cannot be realized, and bionic tooth materials have not made great progress, so as to achieve the effect of improving mechanical properties

Active Publication Date: 2010-11-24
江苏先进无机材料研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on bionic tooth materials has not made great progress. People are still in the preliminary exploration stage for tooth tissue repair and regeneration, and the artificial regeneration of the complex multi-level ordered structure of enamel is still unrealized.

Method used

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  • Enamel-shaped hydroxyapatite and preparation method and application thereof
  • Enamel-shaped hydroxyapatite and preparation method and application thereof
  • Enamel-shaped hydroxyapatite and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The components and parameters specified in Table 1 are respectively used to induce the formation of calcium phosphate salt together with polyethyleneimine (PEI) and maleic acid (MAc). The specific process is as follows: and 24 wt% urea in water. Calcium nitrate and sodium dihydrogen phosphate were then added to the above solution and stirred for 15 minutes. Then the reaction solution was poured into a hydrothermal kettle and reacted at 80°C. After the reaction, it was naturally cooled to room temperature. Finally, the product was suction filtered, washed with water and alcohol, and dried at 40°C for 48 hours.

[0038] The obtained product was characterized by X-ray diffractometer (XRD), field emission scanning electron microscope (FESEM) and transmission electron microscope (TEM). figure 1 Be the scanning electron micrograph of the enamel-like hydroxyapatite that makes in natural tooth enamel and embodiment 1; Wherein figure 1 (a) is a scanning electron micrograph o...

Embodiment 2

[0040] The procedure of Example 1 was repeated at the component levels specified in Table 1 below, but calcium nitrate was replaced with calcium chloride. The result is similar to Example 1.

Embodiment 3

[0042] Repeat the method of Example 1 with the content of each component specified in Table 1 below, but replace sodium dihydrogen phosphate with potassium dihydrogen phosphate. The result is similar to Example 1.

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Abstract

The invention belongs to the technical field of biomedical materials and relates to an enamel-shaped hydroxyapatite and a preparation method and application thereof, in particular to a method for synthesizing the enamel-shaped hydroxyapatite by induction of dual polyelectrolyte. In the method, soluble calcium salt and soluble phosphate are used as raw materials, and the dual polyelectrolyte comprising water-soluble cationic polyelectrolyte and organic polyatomic acid is used as a template; the prepared hydroxyapatite nano rods grow along the specific direction and are mutually stacked closely in parallel to form an enamel-shaped structure; and the diameter of each nano rod is 30-200nm. The method for preparing the hydroxyapatite with the enamel-shaped structure, which is provided by the invention, is not only favorable for people to further understand the biological mineralization processes of enamel crystals but also favorable for improving the mechanical properties of the hydroxyapatite, expands the application of the hydroxyapatite in tooth / bone replacing materials, and provides a new possibility for acquiring and popularizing high-quality medical hydroxyapatite materials.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an enamel-like hydroxyapatite and a preparation method and application thereof. Background technique [0002] Enamel is the white translucent hard tissue with the highest degree of calcification on the outer layer of the crown. It mainly plays the role of protecting the inside of the tooth. It is the hardest substance in the human body, and its hardness is second only to diamond. Its unique mechanical properties are mainly attributed to the highly sophisticated multi-level structure of enamel. The formation of this complex hierarchical structure and the maturation of enamel crystals are accomplished through the consumption of organic components. During enamel formation, as the minerals mature, the amount of protein decreases, resulting in enamel with a high mineral content. This also leads to the inability of the tooth enamel to regenerate spontaneously...

Claims

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Application Information

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IPC IPC(8): C01B25/32A61K6/033A61L27/12A61K6/838
Inventor 祝迎春阮启超
Owner 江苏先进无机材料研究院
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