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Method for preparing vitamin C tablet

A vitamin and tablet technology, which is applied in the field of preparation of vitamin C tablets, can solve problems such as hidden dangers of vitamin C oxidation, and achieve the effects of reducing damage, saving energy, and improving production efficiency

Active Publication Date: 2010-12-01
华北制药河北华维健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the production process, vitamin C will inevitably come into contact with metal ions in machinery and equipment, which also creates hidden dangers of oxidation for vitamin C.

Method used

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  • Method for preparing vitamin C tablet
  • Method for preparing vitamin C tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparing Vitamin C Tablets

[0031] a. Weigh the following raw materials in parts by mass: vitamin C 0.3kg, microcrystalline cellulose 0.044kg, hydroxypropyl cellulose 0.003kg, sodium carboxymethyl starch 0.0065kg;

[0032] b. Weigh 10g of stearyl alcohol, add it to 100ml of 80% ethanol solution, stir and dissolve, and prepare clathrate;

[0033] c. Pass the vitamin C through a 100-mesh sieve, put it into a boiling drying bed or put the vitamin C in a mixer, and spray it into the clathrate solution according to the volume-to-mass ratio of 0.1:1 under boiling or stirring state, dry it, and control the temperature at 45°C ;

[0034] d. Mix the encapsulated vitamin C with the rest of the raw materials evenly, and press it into tablets each containing 0.3g of vitamin C.

Embodiment 2

[0036] Preparing Fruity Vitamin C Tablets

[0037] a. Weigh the following raw materials in parts by mass: 0.1 kg of vitamin C, 0.022 kg of microcrystalline cellulose, 0.015 kg of hydroxypropyl cellulose, 0.0045 kg of sodium carboxymethyl starch, an appropriate amount of magnesium stearate, and 0.0001 kg of lemon essence.

[0038] b. Weigh 10g of stearyl alcohol, add it to 100ml of 95% ethanol solution, stir and dissolve, and prepare clathrate;

[0039] c. Pass the vitamin C through a 100-mesh sieve, put it into a boiling drying bed or put the vitamin C in a mixer, and spray it into the clathrate solution according to the volume-to-mass ratio of 0.1:1 under the stirring state, dry it, and control the temperature at 45°C;

[0040] d. Mix the encapsulated vitamin C with the rest of the raw materials evenly, then add an appropriate amount of magnesium stearate, mix evenly, and press into tablets each containing 0.3g of vitamin C.

Embodiment 3

[0042] Sweetened Vitamin C Tablets

[0043] a. Weigh the following raw materials in parts by mass: 0.15 kg of vitamin C, 0.03 kg of microcrystalline cellulose, 0.025 kg of hydroxypropyl cellulose, 0.05 kg of sodium carboxymethyl starch, and 0.00001 kg of aspartame sweetener.

[0044] b. Weigh 8g of stearyl alcohol, add it to 100ml of 95% ethanol solution, stir and dissolve, and prepare clathrate;

[0045] c. Put the vitamin C through a 100-mesh sieve, put it into a boiling drying bed or put the vitamin C in a mixer, and spray it into the clathrate solution according to the volume-to-mass ratio of 0.1:1 under stirring, and dry it;

[0046] Control the temperature at 45°C;

[0047] d. Mix the encapsulated vitamin C and other raw materials evenly, then add an appropriate amount of magnesium stearate, mix evenly, and compress into tablets.

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Abstract

The invention discloses a method for preparing a vitamin C tablet. The method comprises the following steps of: a, weighting the following raw materials: vitamin C, microcrystalline cellulose, hyprolose and sodium carboxymethyl starch; b, weighting 3 to 10g of octadecanol, adding the octadecanol into 100 ml of 80 to 95 percent of ethanol solution, and stirring the mixture to dissolve so as to prepare inclusion liquor; c, screening the vitamin C with a 100-mesh screen, putting the vitamin C into a fluidized drying bed or a stirrer, spraying the inclusion liquor in a volume mass ratio of 0.1:1 under the state of stirring, drying the mixture, and controlling the temperature to be between 45 and 55 DEG C; and d, putting the dried vitamin C into the stirrer, spraying the inclusion liquor in a volume mass ratio of 0.05-0.1:1 under the state of stirring, drying the mixture, uniformly mixing the included vitamin C and the remaining raw materials, and tabletting the mixture. Compared with the conventional wet granulation process, the method can improve production efficiency by 3 to 5 times and saves energy resources.

Description

technical field [0001] The invention relates to a preparation method of medicines, in particular to a preparation method of vitamin C tablets. Background technique [0002] Vitamin C, also known as ascorbic acid, is a water-soluble vitamin. English name: Vitamin C, Ascorbic Acid. Vitamin C is often used clinically to treat vitamin C deficiency, and it is also an adjuvant drug for many diseases. At present, the pharmaceutical preparations of vitamin C mainly include vitamin C injections and vitamin C tablets. Because vitamin C tablets are convenient to take and have a wide audience, they are widely used clinically. Unfortunately, however, vitamin C is the most unstable of all vitamins. It is easily oxidized by air; it can be destroyed by ultraviolet radiation or by heating during the preparation process, coexistence with metal ions, and various external factors. Therefore, problems such as oxidative discoloration and content decline often occur in vitamin C tablets. For...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/375A61K47/38A61P3/02
Inventor 安英智单金海王志良刘书睿赵霞路玉锋
Owner 华北制药河北华维健康产业有限公司
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