Paeoniflorin and glycyrrhetinic acid composition and preparation method and application thereof

A technology of glycyrrhetinic acid and glycyrrhetinic acid salt, which is applied in the field of medicine, can solve problems such as difficult to determine the mechanism of action and unclear material basis of medicinal effect, and achieve the effect of easy taking, good effect and good therapeutic effect

Active Publication Date: 2010-12-29
NINGBO LIWAH PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The combination of peony and licorice has a long history. It is the classic ancient prescription Shaoyao Gancao Decoction in Zhang Zhongjing's "Treatise on Febrile Diseases. Debating the Syndrome of Taiyang Diseases and Treating It". It has been proved by long-term clinical practice that Shaoyao Gancao Decoction can relieve acute pain and treat various pa

Method used

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  • Paeoniflorin and glycyrrhetinic acid composition and preparation method and application thereof
  • Paeoniflorin and glycyrrhetinic acid composition and preparation method and application thereof
  • Paeoniflorin and glycyrrhetinic acid composition and preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0017] A composition of paeoniflorin and glycyrrhetinic acid, its composition includes: 90% paeoniflorin and 90% glycyrrhetinic acid, the weight ratio of paeoniflorin and glycyrrhetinic acid is 1:1, and its preparation process is as follows: 100 g of paeoniflorin and 100 g of glycyrrhetinic acid were crushed and passed through a 100-mesh sieve, and mixed to obtain a composition of paeoniflorin and glycyrrhetinic acid.

Embodiment 2

[0019] Take the paeoniflorin and glycyrrhetinic acid composition prepared in Example 1, add 20 g of microcrystalline cellulose, add appropriate starch to adjust to 500 g, add magnesium stearate, mix evenly, and directly press the powder into 1000 tablets to make tablets agent.

Embodiment 3

[0021] Take the paeoniflorin and glycyrrhetinic acid composition prepared in Example 1, add an appropriate amount of starch to 300 g, mix evenly, pack into No. 0 capsules, and make 1000 capsules.

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Abstract

The invention provides a paeoniflorin and glycyrrhetinic acid composition and a preparation method and application thereof for treating rheumatoid arthritis and eczema. The composition comprises paeoniflorin and glycyrrhetinic acid in a weight part ratio of 1:0.25-10. The composition can be prepared into various pharmaceutical formulations such as tablets, capsules, pills and the like; and the composition and other active ingredients form amulti-ingredient medicinal composition for providing a medicament with convenient administration and definite effect. The composition has good effect of treating rheumatoid arthritis and eczema.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition composed of paeoniflorin and glycyrrhetinic acid, a preparation method of the composition and its application in treating rheumatoid arthritis and eczema. Background technique [0002] Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic systemic, multiple, common autoimmune disease with a high disability rate that seriously endangers human health and affects the labor force. It is a chronic autoimmune joint disease with synovial inflammation as the main pathological manifestation. Its etiology and pathogenesis are extremely complicated, and at present, there is no definite and effective treatment drug. The etiology and pathogenesis of eczema are quite complex, involving various internal and external factors. It is a delayed type hypersensitivity (DTH) that occurs in the skin and involves immune imbalance in the body. Now mainly use H1 receptor antagonist...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/56A61P19/02A61P29/00A61P17/00
Inventor 周海滨杨海玲江海龙张新明
Owner NINGBO LIWAH PHARM CO LTD
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