Method for preparing fluoridated hydroxyapatite composite and composition thereof

Abstract

The invention relates to a fluoridated hydroxyapatite composite, a manufacture method and a composition containing the fluoridated hydroxyapatite composite. The fluoridated hydroxyapatite composite has a fluoridated hydroxyapatite crystal phase by X-ray diffraction analysis, simultaneously has different functional groups, such as a hydroxyl (OH) and hydroxyl fluorinion hydrogen bond (OH.F) or the hydroxyl (OH) and different hydroxyl fluorinion hydrogen bonds (OH.F and OH.F.HO) or different hydroxyl fluorinion hydrogen bonds (OH.F and OH.F.HO), and the like by Fourier-transform infrared spectrometer detection and has the effect of improving the biological activity of human osteoblasts. The fluoridated hydroxyapatite composite or a composition of the fluoridated hydroxyapatite composite and other compounds of the invention can be used as skeleton bulking agents and can promote the regeneration and restoration of osteocytes. In addition, the composition of the invention can further contain one or more medical compositions of bone regeneration and restoration so that the medical composition is implanted into animals and plants to further facilitate bone tissue regeneration and restoration in vivo.

Description

technical field [0001] The invention relates to the preparation and use of an activated fluorinated hydroxyapatite compound, in particular to the preparation and use of several activated fluorinated hydroxyapatite compounds with different functional groups. Background technique [0002] The method provided by the prior art for the preparation of fluorinated hydroxyapatite needs to be prepared through aqueous solutions of various compounds (L.M. Rodriguez-Lorenzo, J.N. Hart, K.A. Gross. Biomaterials 4; 3777-3785, 2003.). Although there is a convenient preparation method for fluoroapatite, this preparation method cannot prepare a variety of functional group expressions such as hydrogen bonds between hydroxyl and hydroxyl fluoride ions, or hydrogen bonds between hydroxyl and different hydroxyl fluoride ions (C.C.Wu, R.T. Roan, J.H. Chen. Lasers in Surg. and Med. 31; 333-338, 2002.). Therefore, the object of the present invention is to provide a biologically active fluorinated ...

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Problems solved by technology

Although there is a convenient preparation method for fluoroapatite, this preparation method cannot prepare a variety of functional group expressions such as hydrogen bonds between hydroxyl and hydroxyl fluoride ions at the same time, or hydrogen bonds between hydroxyl and different hydroxyl fluoride ions (C.C.Wu, R.T. Roan, J.H. Chen. Lasers in Surg. and Med. 31; 333-338, 2002.)

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