Crystallization method of clindamycin phosphate

Abstract

The invention discloses a crystallization method of clindamycin phosphate, comprising the following steps: firstly dissolving the clindamycin phosphate in n-butanol aqueous solution; then performing crystallization after decoloration, concentration and stepped temperature reduction to below 25 DEG C, filtering, washing, and drying to obtain the finished product. The crystallization method of the clindamycin phosphate of the invention has high crystallization yield, saves the time and reduces the cost; and the clindamycin phosphate finished product has high purity, good mobility and less possibility of agglomeration.

Description

technical field

[0001] The invention relates to a production method of clindamycin phosphate, in particular to a crystallization method of clindamycin phosphate. Background technique

[0002] Clindamycin Phosphate is an antibiotic drug, its chemical name is: methyl 6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7 (S)-Chloro-6,7,8-trideoxy-L-threo-a-D-galactopyranoside-2-phosphate. It has been listed in my country since 1970. Clindamycin phosphate is a chemically semi-synthesized clindamycin derivative, which has no antibacterial activity in vitro. After entering the body, it is rapidly hydrolyzed to clindamycin to exert its pharmacological effects. Its antibacterial spectrum, antibacterial activity and therapeutic effect are the same as clindamycin, but its fat solubility and permeability are better than clindamycin, and it can be administered orally, intramuscularly or intravenously. Compared with lincomycin, clindamycin phosphate has 4-8 times stronger an...

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