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Ointment for treating high blood pressure and preparation method thereof

An ointment and active technology, applied in the field of ointment for the treatment of high blood pressure and its preparation, can solve the problems that the effect needs to be improved, and achieve the effects of reducing the limitation of inability to use drugs, fast absorption, and improved bioavailability

Inactive Publication Date: 2011-01-19
北京水圣木科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The application number is CN200510090104.7, and the invention patent application titled "Clonidine Weekly Transdermal Controlled-release Patch" discloses transdermal administration, but its compatibility with the skin can be released stably for only 7 days, of which The effect of disclosure needs to be improved

Method used

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  • Ointment for treating high blood pressure and preparation method thereof
  • Ointment for treating high blood pressure and preparation method thereof
  • Ointment for treating high blood pressure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The ointment of the present embodiment is prepared from the following components by weight percentage:

[0053] isradipine 2%, urapidil 5%, clonidine 1%, phenoxybenzamine 2%; and include sorbitol, glycerol, parabens, di-tert-butyl-p-cresol, tert-butyl Base 90% including Hydroxyanisole, Gallic Acid, Xanthan Gum, Locust Bean Gum, Gum Arabic, Menthol, Dimethyl Sulfoxide and Laurethrone.

[0054] Wherein the base material volume ratio is:

[0055] Sorbitol 0.2%, Glycerin 0.03%, Parabens 0.75%, Di-tert-butyl-p-cresol 0.036%, tert-butylhydroxyanisole 0.05%, Gallic acid 0.01%, Xanthan gum 0.5% , locust bean gum 0.19%, gum arabic 0.027%, menthol 0.005%, dimethyl sulfoxide 0.32% and lauroazepam 0.15%.

[0056] The preparation method of ointment, comprises the steps:

[0057] 1) Mix the base materials in terms of weight percentage, heat and stir at 60°C to dissolve;

[0058] 2) After the active compound is ground and sieved, it is added to the mixture obtained in step 1) and ...

Embodiment 2

[0060] The ointment of the present embodiment is prepared from the following components by weight percentage:

[0061] Isradipine 20%, Urapidil 13%, Clonidine 10%, Phenoxybenzamine 17%, and include propylene glycol, polyethylene glycol, glycerin, sodium pyrrolidone carboxylate, sorbitol, glycerol, parabens Esters, Sodium Benzoate, Citric Acid, Di-tert-Butyl-p-Cresol, tert-Butyl Hydroxyanisole, Gallic Acid, Propyl Gallate, Sodium Sorbate, Tocopherol, Xanthan Gum, Guar Gum, Capita Gum, locust bean gum, gum arabic, menthol, dimethyl sulfoxide and lauroazepam base 40%.

[0062] Wherein said base material volume ratio is:

[0063] Propylene Glycol 0.005%, Polyethylene Glycol 0.03%, Glycerin 0.07%, Sodium Pyrrolidone Carboxylate 0.0065%, Sorbitol 0.35%, Glycerin 0.57%, Parabens 0.15%, Sodium Benzoate 0.85%, Citric Acid 0.054 %, di-tert-butyl-p-cresol 0.025%, tert-butyl hydroxyanisole 0.035%, gallic acid 0.05%, propyl gallate 0.055%, sodium sorbate 0.15%, tocopherol 0.45%, xanthan ...

Embodiment 3

[0068] The ointment of the present embodiment is prepared from following components by weight percentage:

[0069] Isradipine 5%, Urapidil 7%, Clonidine 3%, Phenoxybenzamine 5%; and including propylene glycol, polyethylene glycol, sorbitol, glycerol, parabens, citric acid, Base consisting of di-tert-butyl-p-cresol, propyl gallate, sodium sorbate, tocopherol, xanthan gum, locust bean gum, gum arabic, menthol, dimethyl sulfoxide and laurocaprone 70% .

[0070] Wherein said base material volume ratio is:

[0071] Propylene glycol 0.11%, polyethylene glycol 0.17%, sorbitol 0.21%, glycerin 0.061%, parabens 0.05%, citric acid 0.03%; di-tert-butyl p-cresol 0.02%, propyl gallate 0.12%, Sodium Sorbate 0.19%, Tocopherol 0.21%, Xanthan Gum 0.1%, Locust Bean Gum and Gum Arabic 0.06%, Menthol 0.071%, Dimethyl Sulfoxide 0.06%, and Laurocaprone 0.28%.

[0072] The preparation method of ointment, comprises the steps:

[0073] 1) Mix the base materials in the weight percentage, heat and st...

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Abstract

The invention relates to a western medicament ointment for treating high blood pressure and preparation method thereof, wherein the ointment contains 10 to 60 weight parts of reactive compounds including isradipine. The preparation method comprises the following steps of: 1) mixing base materials in percentage by weight, heating the mixture at 60 to 90 DEG C and stirring to dissolve the mixture; 2) grinding and sieving the reactive compounds, then adding the reactive compounds into the mixture obtained by the step 1) and stirring for 15 to 25 minutes, and lowering the temperature to 20 to 60 DEG C to obtain finished products. The ointment can be absorbed by human body through skin, and the synergy of active compounds can greatly improve the bioavailability of the ointment; moreover, the ointment has a great degree of security and a few side effects and avoids the symptoms including headache, vertigo, cardiopalmus and face flush basically.

Description

[technical field] [0001] The invention relates to a medicine for treating high blood pressure and its preparation, in particular to an ointment for treating high blood pressure and a preparation method thereof. [Background technique] [0002] At present, there are two kinds of medicines for the treatment of hypertension: traditional Chinese medicine and western medicine. Most of the Western medicines used to treat hypertension are absorbed by the human body in the form of oral administration. As we all know, the harm to the human body caused by the oral administration of traditional Chinese medicine is relatively light, and once the Western medicine enters the human body, it will have different degrees of side effects on the human body, such as: Headache, dizziness, palpitations, facial flushing, etc. caused by vasodilation can be fatal in severe cases. In addition, most drugs for the treatment of hypertension will take into account the patient's other symptoms, which great...

Claims

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Application Information

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IPC IPC(8): A61K31/513A61K31/4439A61K31/4168A61K31/138A61K9/06A61P9/12
Inventor 徐震
Owner 北京水圣木科技有限责任公司
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