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Application of a kind of magnolia alkaloid

A technology of alkaloids and total alkaloids, which is applied in the extraction of alkaloids, the active ingredient of Magnolia officinalis, and the application field of α-glucosidase inhibitors, to achieve the effects of no environmental pollution, low cost, and simple extraction process

Inactive Publication Date: 2012-02-22
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its antibacterial activity can be used for oral care, as publication number is CN101321513, CN101321560, CN1723011, CN1318362, the patent report of CN101222909 application in the oral cavity, so far, there is no α-glucosidase inhibition in Magnolia officinalis Active ingredient reporting

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0018] 10kg of magnolia bark was crushed and extracted with 60L of 0.05% sulfuric acid water. The extract was passed through a D72 macroporous cation exchange resin column (column volume 6L), washed with 20L deionized water, and eluted with 30L of 1% ammonia / ethanol water (70% ethanol) solution. The eluate was evaporated to dryness to obtain 30 g of total alkaloids with a yield of 0.3%.

[0019] A total of 4.0 g of total alkali was taken, and five compounds were separated and purified by silica gel column chromatography (chloroform-methanol gradient elution), and they were identified as magnoliine, liriocarpine, and annonine by mass spectrometry, carbon nuclear magnetic resonance spectrum and hydrogen spectrum. , Roemerine and Lysicamine.

[0020] Take 50g of total alkali of Magnolia officinalis, add 3000g of starch and 30g of microcrystalline cellulose, granulate with 50% ethanol, and tablet to obtain tablets, 0.6g each, containing 10mg of total alkali, which is equivalent to 2g ...

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Abstract

The invention belongs to the technical field of organic chemistry, and relates to a method for extracting alkaloids of magnolia officinalis active ingredients and its application as an alpha-glucosidase inhibitor. The magnolia alkaloids of the present invention include the total alkaloids of magnolia alkaloids, tulipine, citrus alkaloids, romerine and Lysicamine; the bark of magnolia bark is used as a raw material, extracted with an acid aqueous solution at room temperature or by heating; the extract is passed through a strong acid type Or weak acid type cation exchange resin, the active ingredient is adsorbed on the resin; the resin column is first washed with water, then eluted with ammonia / alcohol solution, concentrated and dried to obtain the total alkaloids of magnolia bark. The invention has the characteristics of simple extraction and preparation process, easy operation, low cost and the like.

Description

technical field [0001] The invention belongs to the technical field of organic chemistry, and relates to a method for extracting alkaloids of magnolia officinalis active ingredients and its application as an alpha-glucosidase inhibitor. Background technique [0002] Diabetes is a progressive endocrine disease with glucose metabolism disorder as the main symptom group. The basic pathophysiology is the relative or absolute deficiency of insulin secretion function in the body or abnormal insulin receptor function, which causes metabolic disorders, including sugar, protein, Fat, water and electrolytes etc. The general manifestations are hyperglycemia, diabetes and hyperlipidemia. In severe cases, ketoacidemia may occur, and even circulatory attenuation and coma are life-threatening. Diabetes is divided into four categories, of which type II diabetes accounts for 90-95% of the total number of diabetes. The treatment methods of diabetes mainly include directly supplementing ins...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/575A61P3/10A61P3/04A61P11/00A61P31/16A61K135/00A61K129/00A61K125/00
Inventor 王明奎瞿庆喜喻凯
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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