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Preparation method of capsule for treating pharyngitis and infection of upper respiratory tract and detection method of capsule

A technology of upper respiratory tract and detection method, which is applied in the field of preparation of drugs - An Tai Tuo Capsules, and can solve problems such as the lack of quality control standards

Inactive Publication Date: 2011-03-23
SICHUAN FENGCHUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no relevant quality control standard for the existing medicine made from the traditional Chinese medicinal material Chuanshegan, so it is necessary to provide a quality control detection method for the medicine so that it can effectively control the quality of the medicine preparation and ensure the clinical efficacy

Method used

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  • Preparation method of capsule for treating pharyngitis and infection of upper respiratory tract and detection method of capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Embodiment 1: the preparation method of capsule for the treatment of pharyngitis and upper respiratory tract infection

[0080]Take 350g of Chuanshegan total flavonoids, put it into a hot air circulation dryer and dry it at a temperature of 80°C to 85°C so that the moisture content is lower than 5%, and use a universal pulverizer to prepare the Chuanshegan total flavonoids Pulverize, pass through a 60-mesh sieve, add talc powder of 2% total weight of Chuanshegan total flavonoids fine powder, mix in a multi-directional motion mixer for 30 minutes, make it mix evenly, and fill the uniform mixture into 1 capsule with a capsule filling machine. In No. 2 hard capsules, the Chuanshegan total flavonoids fine powder filled in each capsule is 0.35g, and 1000 capsules are made altogether.

Embodiment 2

[0081] Embodiment 2: the quality detection method one of capsule for the treatment of pharyngitis and upper respiratory tract infection

[0082] Properties: This product is a hard capsule, the content is a brown powder, with a slightly pungent smell and a bitter taste;

[0083] Identification: Take 25mg of the content of this product, put it in a 50ml volumetric flask, dissolve it with 70% ethanol and dilute it to the mark, shake it up, accurately draw 1ml into the 50ml volumetric flask, dilute it with 70% ethanol to the mark, shake it up, that is To obtain the test solution, according to the Chinese Pharmacopoeia 2005 edition one appendix VA spectrophotometry, with 70% ethanol as a blank solution, scan in the wavelength range of 200-400nm, record the spectrogram, there is a maximum absorption at the wavelength of 266 ± 2nm. or

[0084] Take 5mg of the reference substance of sciatica, put it in a 50ml volumetric flask, add 70% ethanol to dissolve it and dilute it to the mark...

Embodiment 3

[0090] Embodiment 3: the quality detection method two of capsules for the treatment of pharyngitis and upper respiratory tract infection

[0091] Properties: This product is a hard capsule, the content is a brown powder, with a slightly pungent smell and a bitter taste.

[0092] Identification: Take 25mg of the content of this product, put it in a 50ml volumetric flask, dissolve it with 70% ethanol and dilute it to the mark, shake it up, accurately draw 1ml into the 50ml volumetric flask, dilute it with 70% ethanol to the mark, shake it up, that is Obtain the test solution, according to Chinese Pharmacopoeia 2005 edition one appendix VA spectrophotometry, take 70% ethanol as blank solution, scan in the range of wavelength 200~400nm, record spectrogram, there is maximum absorption at 266+2nm wavelength. or

[0093] Take 5mg of the reference substance of sciatica, put it in a 50ml volumetric flask, add 70% ethanol to dissolve it and dilute it to the mark, and use it as the ref...

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Abstract

The invention provides a preparation method of a capsule preparation (Antaituo capsule) for treating pharyngitis and infection of the upper respiratory tract and a quality detection method of the capsule. The preparation method comprises the steps of: taking 350 g of iris tectorum maxim total flavonoids, drying to make the moisture content lower than 5%, smashing into fine powder which can pass through a 60-mesh screen, adding talcum powder accounting for1-3% by weight of the fine power,mixing evenly, and loading into a number one hard capsule. Besides a check on general projects according to the pharmacopoeia general rule, in the detection method, methods for identifying the main active ingredient tectoridin are formulated, comprising spectrophotometry and thin layer chromatography; the content of the iris tectorum maxim total flavonoids is determined through the spectrophotometry to ensure that the quantity of the active ingredient is more steady, and the quality of the preparation is effectively controlled to ensure the clinical effects, thereby the safe and effective medication for people is ensured.

Description

technical field [0001] The invention relates to a pure traditional Chinese medicine preparation, in particular to a preparation method of An Tai Tu capsule, a medicine for treating pharyngitis and upper respiratory tract infection, and a quality detection method thereof. Background technique [0002] An existing medicine for treating pharyngitis and upper respiratory tract infection is a traditional Chinese medicine decoction made by decocting the Chinese herbal medicine Chuanshegan. , laryngitis and acute upper respiratory tract infection caused by sore throat, hoarseness, cough yellow phlegm has a very good effect. However, it has the disadvantages of troublesome decoction, difficult storage, inconvenient carrying and taking, and inconvenient accurate dosage. Some people have extracted the active ingredients of Chuanshegan from the traditional Chinese medicinal material Chuanshegan, the total flavonoids of Chuanshegan, and took it directly. It also has the disadvantages o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/88G01N21/25G01N30/90A61P11/04A61P11/00
Inventor 钟茂团黎勇邹波古莉温国梁
Owner SICHUAN FENGCHUN PHARMA
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