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Daidzein-entrapped PLGA nanoparticles and preparation method thereof

A technology of daidzein and nanoparticles, applied in the field of PLGA nanoparticles loaded with daidzein and its preparation

Inactive Publication Date: 2012-07-04
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the dosage form of daidzein PLGA nanoparticles.

Method used

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  • Daidzein-entrapped PLGA nanoparticles and preparation method thereof
  • Daidzein-entrapped PLGA nanoparticles and preparation method thereof
  • Daidzein-entrapped PLGA nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of daidzein PLGA nanoparticles by composite method

[0030] (1) Put 2 mg of daidzein and 20 mg of lecithin into a sample bottle, add 2 mL of ethanol into the bottle, seal it, shake it at a constant temperature of 40°C for 48 hours, and take it out.

[0031] (2) Dry the ethanol in the bottle with nitrogen to form a complex.

[0032] (3) Take 60 mg of PLGA and dissolve it in 2 mL of dichloromethane.

[0033] (4) The compound is added into dichloromethane and stirred evenly, as the organic phase.

[0034] (5) Prepare 60 mL of 1% PVA aqueous solution as the water phase.

[0035] (6) Put the water phase under the ultrasonic probe of the type ultrasonic conductivity meter, the working power is 600w, and the organic phase is slowly added dropwise to the water phase under the ultrasonic state; after the dropping, continue to ultrasonicate for 2 to 5 minutes.

[0036] (7) The emulsion formed by ultrasound was quickly transferred to a rotary evaporator, ...

Embodiment 2

[0041] Example 2: The steps are the same as in Example 1, but 20 mg of lecithin is 140 mg of hydroxypropyl-β-cyclodextrin, ethanol is methanol, and the compound is added into dichloromethane and stirred evenly to form a 2% aqueous solution of PVA for the compound After 0.5mL was dissolved, it was added to dichloromethane, and homogenized at a high speed of 10,000 rpm and stirred evenly.

Embodiment 3

[0042] Embodiment 3: The steps are the same as in Embodiment 1, but the lecithin quality is 10 mg.

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Abstract

The invention relates to daidzein-entrapped polylactic polyglycolic acid (PLGA) nanoparticles and a preparation method thereof in the technical field of nanomedicines. The nanoparticles comprise the following components in percentage by mass: 0.1 to 45 percent of daidzein, 25 to 95 percent of polylactic polyglycolic acid and 1 to 65 percent of pharmaceutic adjuvant, wherein the molecular weight of the PLGA is between 8,000 and 15,000, the polylactic polyglycolic acid is long-chain macromolecules in which the ratio of the lactic acid to glycollic acid is 50:50, and the pharmaceutic adjuvant islecithin, cyclodextrin or polyvinyl alcohol (PVA). The daidzein-entrapped PLGA nanoparticles have the particle size of between 280 and 330 nanometers and concentrated particle size distribution, redissolved freeze-dried powder is not adhered, and the medicine loading rate of the PLGA nanoparticles is between 1 and 2 percent, and the encapsulating rate is between 80 and 84 percent.

Description

technical field [0001] The present invention relates to a preparation in the technical field of nano-medicines and a preparation method thereof, in particular to a PLGA nanoparticle loaded with daidzein and a preparation method thereof. Background technique [0002] For many drugs, oral administration is an economical, safe and compliant route of administration. However, many drugs have poor bioavailability due to their poor solubility, which limits the use of drugs to a certain extent. [0003] Daidzein belongs to flavonoids, and its water solubility and fat solubility are poor, and its absorption in the gastrointestinal tract is small, resulting in low drug bioavailability and ineffective effects. Therefore, how to improve the absorption of daidzein so that it can be utilized by the body is the purpose of the development of new dosage forms of daidzein. [0004] Nanoparticles, as a colloidal drug carrier, have significant advantages such as improving drug stability and c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K47/34A61K31/352A61P3/10A61P9/10A61P39/06
Inventor 沈琦赵心怡马依然于苏甫
Owner SHANGHAI JIAOTONG UNIV
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