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Water resistant patch preparation

A product and patch technology, applied in the field of waterproof patch products, can solve the problems of not being able to ensure sufficient adhesion of the skin surface, easy to generate wrinkles, and reduce performance without warning, so as to improve the removal performance, prevent adhesion to clothing, and inhibit washing. Lifting effect

Active Publication Date: 2011-04-13
安柏士有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This document describes, "When the thickness of the peripheral part is too large, the edge of the peripheral part is easily peeled off during application, and when it is too thin, sufficient adhesion to the skin surface cannot be ensured and prone to creases in
However, it does not describe or suggest that the side extremities of the adhesive layer in the peripheral portion lie within the side extremities of the carrier, nor does it warn about the problem of reduced efficacy due to contact with water, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126]

[0127] Under an inert gas atmosphere, 2-ethylhexyl acrylate (95 parts by weight), acrylic acid (5 parts by weight) and benzoyl peroxide (0.2 parts by weight) were solution polymerized in ethyl acetate at 60°C, thereby An acrylic adhesive solution is provided.

[0128] In the presence of ethyl acetate, the acrylic adhesive, the organic liquid component (isopropyl palmitate) and the drug (isosorbide dinitrate, a therapeutic drug for angina pectoris) were mixed at a ratio of 43:40:17. weight ratio mix. In addition, CORONATE HL (manufactured by Nippon Polyurethane Industry Co., Ltd.) was mixed as a crosslinking agent at a solid content of 0.15 parts by weight with respect to 100 parts by weight of the acrylic adhesive, thereby providing a solid content for forming the adhesive layer. combination.

[0129]

[0130] The above composition was applied to the easy-release surface of a release liner (thickness 75 μm) made of PET so that the thickness of the adhesive layer...

Embodiment 2

[0134]

[0135] In the presence of hexane, polyisobutene 1 with high molecular weight (viscosity average molecular weight 4,000,000), polyisobutylene 2 with low molecular weight (viscosity average molecular weight 80,000), tackifier (alicyclic saturated hydrocarbon resin, softening point 100 °C (ring and ball method)), organic liquid components (isopropyl palmitate) and drugs (tulobuterol, bronchodilators) were mixed in a weight ratio of 15:20:20:35:10 to provide Composition of the adhesive layer.

[0136]

[0137] The above composition was applied to the easy-release surface of a PET release liner (thickness 75 μm) so that the thickness of the adhesive layer after drying was 200 μm, and dried in a drying oven (70° C.) to provide a release liner with an adhesive layer end. The surface with the adhesive layer was laminated on a support, which was a PET film having a thickness of 12 μm, by pressure bonding to provide an adhesive sheet for die-cut patch preparations.

[013...

experiment Embodiment 1

[0161]

[0162] The patch preparations were cut using a razor for trimming, their cross-sections were observed with a digital microscope (Keyence Corporation, VHX-600, magnification 1000 times), and the thicknesses of the adhesive layers in the peripheral portion and the central portion were measured. Furthermore, the cross-sectional shape of the side end of the adhesive layer was observed, and the distance from the side end of the carrier to the portion of the adhesive layer located closest to the central portion was measured. The results are shown in Table 1.

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Abstract

The present invention provides a water resistant patch preparation having a central part and a peripheral part, which preparation is comprised of a support and an adhesive layer comprising a drug, which is formed on one surface of the support, wherein at least a part of a lateral end of the adhesive layer in the peripheral part is located inside a lateral end of the support, and the adhesive layer in the peripheral part has a thickness smaller than that of the adhesive layer in the central part.

Description

technical field [0001] The present invention relates to a water resistant patch preparation comprising a support and a drug-containing adhesive layer laminated on at least one surface of the support. Background technique [0002] As products for administering drugs to the body to treat or prevent diseases, there can be mentioned, for example, percutaneous absorption products, which can avoid drug metabolism and various side effects due to the first pass through the liver, and can continuously administer drugs for a long time. Among those, patch preparations containing drugs in adhesives have been developed because administration operations are simple and the dosage can be strictly controlled. [0003] In general, patch preparations contain a carrier made of fabric, plastic film, etc., and a drug-containing adhesive layer laminated on the carrier, and are provided with a release liner laminated on the adhesive layer (release liner) and provided in a package made of resin fil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/34
CPCA61F13/023A61F2013/0071A61F2013/00651A61K9/703A61K9/7038
Inventor 青柳和宏岩男美宏松冈贤介
Owner 安柏士有限公司
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