Dimeticone emulsion and preparation method thereof

A technology of simethicone emulsion and simethicone, which is applied in the direction of medical formula, emulsion delivery, and medical preparations of non-active ingredients, etc., which can solve the inconvenience of infants and young children, the inconvenience of the discharge of tiny bubbles in the gastrointestinal tract, and the restriction of gastric Relief of flatulence and other problems

Inactive Publication Date: 2011-05-11
四川健能制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing simethicone is often prepared into solid oral preparations, which is inconvenient for infants and young children. In addition, simethicone is an oily substance, and the dispersibility of solid dosage forms is not good, which is not convenient for the discharge of tiny air bubbles in the gastrointestinal tract, which limits the gastrointestinal tract. gas relief

Method used

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  • Dimeticone emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. Prescription:

[0021]

[0022] 2. Process steps:

[0023] (1) After mixing simethicone and silicon dioxide, place it in an oven at 170°C for 4 hours at a constant temperature, take it out and cool to room temperature to obtain a simethicone-silica compound for use;

[0024] (2) Sodium carboxymethyl cellulose is dispersed in 500ml of water to make a uniform solution for later use;

[0025] (3) Dissolve 2,6-di-tert-butyl-p-cresol in ethanol to make a uniform ethanol solution for later use;

[0026] (4) Mix polysorbate and Span evenly to make a mixed emulsifier, set aside;

[0027] (5) Sodium saccharin, fresh milk essence, and ethyl paraben are dissolved in 100ml of water to make a uniform solution for later use;

[0028] (6) Mix simethicone silica compound and mixed emulsifier at 75°C, add 200ml of 75°C water, homogenize in a homogenizer for 3 minutes, homogenize at a speed of 10000r / min, then stir, cool, and stir at a speed of 20r / min;

[0029] (7) In step 6...

Embodiment 2

[0032] 1. Prescription:

[0033]

[0034] 2. Process steps:

[0035] (1) After mixing simethicone and silicon dioxide, place it in an oven at 170°C for 6 hours at a constant temperature, take it out and cool to room temperature to obtain a simethicone-silica compound for use;

[0036] (2) Sodium carboxymethylcellulose is dispersed in 600ml of water to make a uniform solution for later use;

[0037] (3) Dissolve 2,6-di-tert-butyl-p-cresol in ethanol to make a uniform ethanol solution for later use;

[0038] (4) Mix polysorbate and Span evenly to make a mixed emulsifier, set aside;

[0039] (5) Sodium saccharin, fresh milk essence, and ethyl paraben are dissolved in 100ml of water to make a uniform solution for later use;

[0040] (6) Mix the simethicone silica compound and the mixed emulsifier at 80°C, add 150ml of 80°C water, homogenize in the homogenizer for 5 minutes, the homogenization speed is 7000r / min, then stir, cool, and the stirring speed is 30r / min;

[0041]...

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Abstract

The invention discloses a dimeticone emulsion. Every 1000ml of dimeticone emulsion is prepared from 20g of dimeticone, 0.3-0.5g of silicon dioxide, 5-8g of polysorbate, 5-10g of Span, 5-10g of sodium carboxymethyl cellulose, 0.05-0.15g of 2,6-di-tert-butyl-para-cresol, 0.05-0.1g of saccharin sodium, 0.5-2g of ethylparaben, 10-20ml of ethanol, 0.1-0.3g of fresh milk essence and the balance of water. The dimeticone emulsion has the advantages of high stability and favorable defoaming capability. The invention also discloses a preparation method for the dimeticone emulsion. The preparation method disclosed by the invention has the advantages of simple technique and low energy consumption, and lowers the production cost; and the prepared dimeticone emulsion has favorable uniformity.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a medicine for eliminating bubbly mucus in the stomach and expelling intestinal gas, in particular to a simethicone emulsion and a preparation method thereof. Background technique [0002] Simethicone is a dimethylsiloxane polymer, which is a commonly used medical defoamer in clinical practice. Because of its small surface tension, it can change the surface tension of bubbles and make them burst, thereby eliminating foam. [0003] Existing simethicone is often prepared into solid oral preparations, which is inconvenient for infants and young children. In addition, simethicone is an oily substance, and the dispersibility of solid dosage forms is not good, which is not convenient for the discharge of tiny air bubbles in the gastrointestinal tract, which limits the gastrointestinal tract. Gas relief. [0004] Japanese patent JP57206611A discloses a simethicone emulsion and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/80A61K47/38A61P1/00
Inventor 刘萍王国华杨勇
Owner 四川健能制药有限公司
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