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Freeze-dried powder injection for treating coronary heart disease and preparation method thereof

A technology for freeze-dried powder injection and coronary heart disease, which can be used in freeze-dried delivery, cardiovascular system diseases, medical preparations containing active ingredients, etc. The effect of carrying and transporting

Inactive Publication Date: 2011-05-11
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The arteriosclerosis we usually refer to actually includes the above two lesions, so it is not accurate enough.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 200 g of total saponins of Scutellaria baicalensis, add water and decoct three times, each time for 1.0 h, combine the decoction, filter, and concentrate the filtrate to about 2000 ml (0.1 MP, 70°C). The concentrated solution was purified by HPD-100 macroporous adsorption resin column, first eluted with 4BV distilled water, then 30% ethanol 6BV, collected the 30% ethanol eluate, and concentrated to 100mL under reduced pressure to obtain the total saponins of Scutellaria baicalensis things.

[0042] Weigh 2000g of Ligusticum chuanxiong, add 10 times the amount of 95% ethanol to reflux and extract 3 times, each time for 1.5h, filter the extract, combine the extract, recover ethanol (0.1MP, 60°C) under reduced pressure, and add appropriate amount of distilled water to heat and dissolve. Suction. The filtrate was passed through a macroporous adsorption resin column, washed with water, and then eluted with 30% ethanol. The 30% ethanol eluate was collected and concentr...

Embodiment 2

[0045] Weigh 100 g of total saponins of Scutellaria baicalensis, add 8 times the amount of 30% ethanol to reflux and extract 3 times, each time for 1 h, combine the decoction, filter, and concentrate the filtrate to about 1000 ml (0.1MP, 70°C). The concentrated solution was purified by a D101 macroporous adsorption resin column, first eluted with 4BV of distilled water, then 40% ethanol 6BV, collected the 40% ethanol eluate, and concentrated under reduced pressure to 50mL to obtain the total saponin extract of Scutellaria baicalensis.

[0046] Weigh 100g of Ligusticum chuanxiong, add 10 times the amount of 80% ethanol to reflux and extract for 3 times, each time for 1h, filter the extract, combine the extract, recover ethanol (0.1MP, 60°C) under reduced pressure, add appropriate amount of distilled water to dissolve, and extract filter. The filtrate was passed through a D101 macroporous adsorption resin column, washed with water, and then eluted with 30% ethanol. The 30% ethan...

Embodiment 3

[0049] Weigh 200g of the total saponins of Scutellaria baicalensis, 200g of Chuanxiong medicinal materials, and the above two flavors, add water and decoct three times, 1.0h each time, combine the decoctions, filter, and concentrate the filtrate to about 2000ml (0.1MP, 70°C). The concentrated solution was purified by HPD-100 type macroporous adsorption resin column, eluted with 4BV distilled water first, then eluted with 30% ethanol 6BV, collected the 30% ethanol eluate, and concentrated under reduced pressure to 100mL to obtain total saponins of baicalin and Chuanxiong Extract. Scutellaria baicalensis total saponins and Chuanxiong extract are diluted to 500mL with water for injection, add 25g of glucose and 10g of sorbitol to dissolve, add water for injection to make 1000mL, sterilize by ultrafiltration membrane filtration (6000 molecular weight), and fill in aseptically Put it in 5mL sterilized vials (2mL per bottle), freeze-dry in a freeze dryer, seal the seal, and obtain t...

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PUM

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Abstract

The invention provides freeze-dried powder injection for treating coronary heart disease and a preparation method thereof. The powder injection consists of the following components in part by weight: 50 to 100 parts of extract of total saponins of baical skullcap root, and extract of szechuan lovage rhizome, and 0 to 50 parts of excipient. The Guanxinning powder injection has the characteristics of quick response, strong effect, high dissolubility and stable property, and is more suitable for treating cardiovascular diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof. More specifically, it is a freeze-dried powder injection containing baicalin total saponins extract and Chuanxiong extract and a preparation method thereof. Background technique [0002] In today's world, many scientifically developed countries have been able to control many diseases that endanger human life, and the average life expectancy has been continuously extended, and the mortality rate of cardiovascular system diseases has risen to the first or second place accordingly. As far as coronary heart disease is concerned, about 500,000 people die in the United States every year, accounting for 1 / 3 to 1 / 2 of the total population deaths, accounting for 50% to 70% of the number of deaths from heart disease; rate of 10 to 20%, and an upward trend. Take Beijing, a city with a relatively high standard of living in the country, as an example. The inciden...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61K9/19A61P9/10
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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