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Traditional Chinese medicine composition and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of preparation of traditional Chinese medicine composition and the composition, can solve the problems of skin flushing and itching, muscle pain, gastrointestinal discomfort, skin itching and the like

Active Publication Date: 2014-11-12
山东禹泽药康产业技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Western medicine treatment of hyperlipidemia has a certain curative effect, it has side effects in varying degrees, such as statins (simvastatin, lovastatin) easily lead to gastrointestinal discomfort, muscle pain, fibrates (fenofibrate, benzalkine) Bet) can easily cause gastrointestinal discomfort, skin itching, gallstones and other symptoms, and niacin (pentetrol, Lezhiping) can easily cause skin flushing and itching, peptic ulcer, gout, etc.

Method used

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  • Traditional Chinese medicine composition and preparation method thereof
  • Traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Prescription: Gualou skin 500g, scallions 500g, red yeast rice 450g, hawthorn leaves 250g, lotus leaves 450g

[0070] Preparation method: take the above six flavors, take scallions and red yeast rice, reflux twice with 4 times the amount of ethanol, 1.5 hours each time, filter, recover the ethanol, and dry under reduced pressure; add 4 times the amount of 50% ethanol to the dregs and reflux twice, Every 1.5 hours, recover ethanol, concentrate, add ethanol to 75%, recover ethanol, concentrate, and dry under reduced pressure; add 8 times the amount of water to decoct for 2 times, 1.5 hours each time, and concentrate , add ethanol to 60%, recover ethanol, and dry under reduced pressure; the above-mentioned dry matter is mixed, pulverized, and added to the matrix (PEG4000:PEG6000=1:1) melted at 70°C in a weight ratio of 1:2, and fully stirred. Keep warm, drop into simethicone at about 10°C, centrifuge, dry, and select pellets to obtain.

Embodiment 2

[0072] Prescription: Gualou skin 700g, scallions 700g, red yeast rice 300g, hawthorn leaves 400g, lotus leaves 600g

[0073] Preparation method: take the above six flavors, take scallions and red yeast rice, reflux 3 times with 6 times the amount of ethanol, 0.5h each time, filter, recover ethanol, and dry under reduced pressure; add 6 times the amount of 50% ethanol to the dregs and reflux twice, For 2 hours, recover ethanol, concentrate, add ethanol to 70%, recover ethanol, concentrate, and dry under reduced pressure; add 7 times the amount of water to decoct the skin of Trichosanthes quince, hawthorn leaves, and lotus leaves twice, each time for 2 hours, concentrate, add Ethanol to 70%, recovered ethanol, and dried under reduced pressure; the above-mentioned dry matter was mixed, crushed, an appropriate amount of starch was added, mixed evenly, and capsules were obtained.

Embodiment 3

[0075] Prescription: Gualou skin 300g, scallions 300g, red yeast rice 500g, hawthorn leaves 400g, lotus leaves 700g

[0076] Preparation method: take the above six flavors, take scallions and red yeast rice, reflux 3 times with 3 times the amount of ethanol, 1.5 hours each time, filter, recover the ethanol, and dry under reduced pressure; For 1 hour, recover ethanol, concentrate, add ethanol to 60%, recover ethanol, concentrate, and dry under reduced pressure; add 7 times the amount of water to decoct 3 times for 2 hours each time, concentrate, add Ethanol to 70%, recover ethanol, and dry under reduced pressure; the above-mentioned dry matter is mixed, crushed, mixed evenly, and added to PEG6000 melted at 80°C in a ratio of 1:2 by weight, fully stirred, kept warm, and dropped to about 10°C In simethicone oil, centrifuge, dry, select pellets, and obtain.

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Abstract

The invention discloses a traditional Chinese medicine composition, which belongs to the field of traditional Chinese medicines. The composition is prepared from Pericarpium trichosanthis, longstamen onion bulb and other bulk pharmaceutical chemicals by the steps of extracting effective ingredients with ethanol of difference concentrations or water according to different properties of the medicinal materials, and making into capsules, soft capsules, dropping pills, tablets or pills. The composition can be used for treating hyperlipoidemia, coronary heart disease, hypercholesterolemia, atherosclerosis and other diseases in clinics. The invention also discloses a preparation method of the traditional Chinese medicine composition.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition and a preparation method of the composition, in particular to a traditional Chinese medicine composition for hyperlipidemia, hypercholesterolemia, coronary heart disease and atherosclerosis and a preparation method thereof. Background technique [0002] Hyperlipidemia is a disease in which the levels of total cholesterol, low-density lipoprotein cholesterol and triacylglycerol in serum rise above the upper limit of the normal range due to abnormal lipid metabolism or operation. A large number of evidence-based medical studies have confirmed that hyperlipidemia is closely related to atherosclerotic diseases, and has been listed as an important independent risk factor for cardiovascular and cerebrovascular diseases. Clinically, hyperlipidemia and obesity are diseases caused by excessive calorie intake and excessive accumulation of fat tissue in the body due to biochemical and physiolo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P3/06A61P9/10
Inventor 代龙孙志强
Owner 山东禹泽药康产业技术研究院有限公司