Gardenia total polyene composition, preparation method thereof and application thereof to medicaments

A kind of composition, the technology of gardenia, applied in the field of medicine, can solve the problems such as no literature mentioning pharmacological activity and use

Inactive Publication Date: 2011-06-15
广州艾格生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many literature reports on the anti-tumor, anti-atherosclerosis, anti-hypertensive and treatment of hemorrhagic shock, anti-oxidation, liver-protecting and choleretic effects of single compounds such as crocetin and crocetin; bu

Method used

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  • Gardenia total polyene composition, preparation method thereof and application thereof to medicaments
  • Gardenia total polyene composition, preparation method thereof and application thereof to medicaments
  • Gardenia total polyene composition, preparation method thereof and application thereof to medicaments

Examples

Experimental program
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Example Embodiment

[0056] Example one

[0057] Take 10kg of gardenia, crush it, extract three times with petroleum ether (60-90℃) for 1 hour each time, extract the medicine residue three times with ethanol, combine the three filtrates, recover the ethanol until there is no alcohol, and the treated D101 macroporous resin Column, first water elution, 25% ethanol elution, collect 35% ethanol eluate, concentrate the eluate to dryness, dissolve the eluate with ethanol and mix the sample with silica gel, and load the silica gel column with ethyl acetate: methanol: water = 9 : 2:1 elution, collect a total of conjugated polyene compound sites, the content of gardenia conjugated polyene compound is determined to be 98.7%. Among them are mainly crocetin and crocin, and the content ratio is 50:50.

Example Embodiment

[0058] Example two

[0059] Take 10kg of gardenia, crush it, extract three times with petroleum ether (60-90℃) for 1 hour each time, extract three times with ethanol for the medicine residue, combine the three filtrates, recover the ethanol until there is no alcohol smell, and the treated AB-8 Porous resin column, first water elution, 20% ethanol elution, collect the 40% ethanol eluate, concentrate the eluate to dryness, dissolve the eluate with ethanol and mix the sample with silica gel, and load the silica gel column with ethyl acetate: methanol: water = 10: 2: 1 elution, collect a total of conjugated polyene compound sites, the content of gardenia conjugated polyene compound is determined to be 67%. Among them are mainly crocetin, crocetin and methyl crocetin, with a content ratio of 30:68:2.

Example Embodiment

[0060] Example three

[0061] Take 10kg of gardenia, crush it, and extract three times with petroleum ether (60-90℃) for 1 hour each time. The medicine residue is extracted three times with ethanol. The three filtrates are combined to recover the ethanol until there is no alcohol. The treated D104 macroporous resin Column, first water elution, 20% ethanol elution, collect the 35% ethanol eluate, concentrate the eluate to dryness, dissolve the eluate with ethanol and mix the sample with silica gel, and load the silica gel column with ethyl acetate: methanol: water = 11 : 2:1 elution, collect a total of conjugated polyene compound sites, the content of gardenia conjugated polyene compound is determined to be 93.2%. Among them are mainly crocetin, crocetin and dimethyl crocetin, with a content ratio of 34:65:1.

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Abstract

The invention relates to a gardenia total conjugate polyene composition, a preparation method thereof and application thereof to medicaments, and belongs to the field of the medicaments. According to tests, conjugate polyene compounds in gardenia have synergistic effect. Tumor resistance, hypertension resistance and hyperlipidemia resistance of the gardenia total conjugate polyene composition are higher than those of a control group and a single polyene compound such as crocetin and crocin. The preparation method of the gardenia total conjugate polyene composition is provided.

Description

technical field [0001] The invention relates to a total conjugated polyene composition of Gardenia jasminoides, a preparation method thereof and an application in medicine, belonging to the field of medicine. Background technique [0002] Gardenia is the dry ripe fruit of plants in the genus Gardenia of the Rubiaceae plant. Produced in the provinces south of the Yangtze River. Gardenia is a traditional Chinese medicine, which belongs to the first batch of medicinal and edible resources promulgated by the Ministry of Health. contusion, high blood pressure, diabetes and other diseases. In addition to its application in traditional Chinese medicine, gardenia is mainly used as a raw material for extracting natural pigments, and is used to prepare gardenia blue, gardenia red, and gardenia yellow pigments. [0003] Studies have found that there are many chemical components in gardenia, mainly: iridoid glycosides and organic acids. Among them, the iridoid glycoside compounds in...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K31/194A61K31/22A61K9/20A61K9/48A61K9/16A61K9/00A61K9/08A61K9/14A61P35/00A61P9/00A61P9/12A61P3/10A23L1/29A23L33/00
Inventor 张雷红
Owner 广州艾格生物科技有限公司
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