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Total lignan extract of stalkedfruit pricklyash bark for treating arthritis

A technology of hemp skin seeds and total lignans, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as arthritis literature reports that have not yet been reported, and can improve collagen-induced arthritis, reduce dosage, and reduce toxic side effects

Active Publication Date: 2011-06-15
湖南药圣堂中药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] After searching, there is no literature report on the treatment of arthritis with the total lignan extract of Makoupizi medicine

Method used

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  • Total lignan extract of stalkedfruit pricklyash bark for treating arthritis
  • Total lignan extract of stalkedfruit pricklyash bark for treating arthritis
  • Total lignan extract of stalkedfruit pricklyash bark for treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 100kg of Makoupizi medicinal materials, add 70% ethanol to reflux extraction twice, each time for 1 hour, add 800kg70% ethanol for the first time, add 600kg70% ethanol for the second time, filter, combine the extracts, extract Recover ethanol and concentrate it into a thick paste, add an appropriate amount of absolute ethanol to dissolve, mix well with the same weight of macroporous adsorption resin, add water more than 10 times the amount of absolute ethanol, stir, and add to the treated macroporous adsorption resin column , first eluted to colorless with 30% low-concentration ethanol, discarded the 30% ethanol eluate, then eluted with 90% ethanol until colorless, collected the 90% ethanol eluate, recovered ethanol and Concentrate into a thick paste with a relative density of 1.25, and dry it in vacuum to obtain the total lignan extract of the herba japonica containing 30% of the total lignans.

Embodiment 2

[0034] Take 100kg of the medicinal material of Makoupizi, add 90% ethanol to reflux and extract twice, each time for 1.5 hours, add 700kg90% ethanol for the first time, add 600kg90% ethanol for the second time, filter, combine the extracts, extract Recover ethanol and concentrate it into a thick paste, add an appropriate amount of absolute ethanol to dissolve, mix well with the same weight of macroporous adsorption resin, add water more than 10 times the amount of absolute ethanol, stir, and add to the treated macroporous adsorption resin column , first eluted to colorless with 30% low-concentration ethanol, discarded the 30% ethanol eluate, then eluted with 80% ethanol until colorless, collected the 80% ethanol eluate, recovered ethanol and Concentrate into a clear paste with a relative density of 1.10, and spray dry to obtain the total lignans extract of the hemp seed medicine containing 60% of the total lignans.

Embodiment 3

[0036] Take 100kg of the medicinal material of Makoupizi, add 80% ethanol to reflux and extract twice, each time for 2 hours, add 800kg80% ethanol for the first time, add 600kg80% ethanol for the second time, filter, combine the extracts, extract Recover ethanol and concentrate it into a thick paste, add an appropriate amount of absolute ethanol to dissolve, mix well with the same weight of macroporous adsorption resin, add water more than 10 times the amount of absolute ethanol, stir, and add to the treated macroporous adsorption resin column , first eluted to colorless with 30% low-concentration ethanol, discarded the 30% ethanol eluate, then eluted with 90% ethanol until colorless, collected the 90% ethanol eluate, recovered ethanol, Vacuum drying, that is, dry extract. Add 5 times the amount of water to the dry extract to suspend, extract 4 times with ethyl acetate, each time the amount of ethyl acetate is equal to the sample volume, combine the ethyl acetate layers, recov...

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Abstract

The invention discloses a total lignan extract of stalkedfruit pricklyash bark, which is characterized in that the content of total lignan is above 30%. The total lignan extract of stalkedfruit pricklyash bark is extracted and refined from the traditional Chinese medicine stalkedfruit pricklyash bark. Proven by pharmacodynamical and toxicological tests, the total lignan extract of stalkedfruit pricklyash bark can obviously improve the collagen induced arthritis of rats, and simultaneously has better analgesis and anti-inflammation effects with small toxic side effects. The invention also discloses a medical application of the total lignan extract of stalkedfruit pricklyash bark.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an effective part extracted from traditional Chinese medicine Makoupizi medicine, and also relates to a preparation method of the effective part and its medical application. Background technique [0002] Arthritis is a common chronic disease, the most common of which are rheumatoid arthritis and rheumatoid arthritis. It is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. According to statistics, half of the people over the age of 50 in my country suffer from rheumatoid arthritis; 90% of the women and 80% of the men over the age of 65 suffer from rheumatoid arthritis. The prevalence of rheumatoid arthritis in my country is 0.5%. [0003] Rheumatoid arthritis (RA) is a multisystem inflammatory autoimmune disease. An autoimmune disease is a disease state caused by the body's immune system reactin...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P19/02
Inventor 周小江
Owner 湖南药圣堂中药科技有限公司
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