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Application of Chinese medicine composition in preparation of medicament for treating overhigh level of urine cell factor or receptor thereof and Escherichia coli infection

A technology of Escherichia coli and cytokines, applied in the field of medicine, can solve the problems of reducing sIL-2R, no bacteriostatic and bactericidal effects of Escherichia coli, and achieve the effect of solving bottlenecks and considerable clinical value

Active Publication Date: 2011-06-15
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And so far, no report has been found that the above composition can effectively reduce the levels of sIL-2R, urinary IL-6, and urinary IL-8
Although there are reports of the above-mentioned composition treating related diseases accompanied by elevated levels of sIL-2R, urinary IL-6, and urinary IL-8, the treatment is the result, and no one or several links or targets are used in detail. The disease is treated by the effect of the point, and there is no report on how the above-mentioned composition produces antibacterial and bactericidal effects on Escherichia coli

Method used

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  • Application of Chinese medicine composition in preparation of medicament for treating overhigh level of urine cell factor or receptor thereof and Escherichia coli infection
  • Application of Chinese medicine composition in preparation of medicament for treating overhigh level of urine cell factor or receptor thereof and Escherichia coli infection
  • Application of Chinese medicine composition in preparation of medicament for treating overhigh level of urine cell factor or receptor thereof and Escherichia coli infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Raw materials: 800g golden cherry root, 400g sarsaparilla, 390g sheep opening, 250g golden sand vine, 260g centella asiatica

[0037] The raw material is decocted with water and extracted twice, the first time is 3 hours, and the second time is 2 hours. The extracted filtrate is placed in a vacuum concentration tank and concentrated into a thick paste (d=1.15~1.30 / 70°C~80°C). The thick paste is conventionally dried, and the water content of the obtained dry paste powder is ≤5%. Take the dry cream powder, add appropriate amount of talcum powder, dry starch, etc., granulate by conventional method, add auxiliary materials (such as silicon dioxide, magnesium stearate, microcrystalline cellulose, etc.) The dosage is controlled between 3.0% and 10.0%, compressed into tablets, each large tablet is equivalent to 3.5g of the original medicinal material; each small tablet is equivalent to 2.1g of the original medicinal material, and coated to obtain a finished product. The produ...

Embodiment 2

[0039] Raw materials: golden primrose 750g, sarsaparilla 460g, sheep opening 440g, golden sand vine 260g, centella asiatica 280g

[0040] The raw material is decocted and extracted twice, the first time is 3 hours, the second time is 2 hours, and the extracted filtrate is concentrated into a thick paste (d=1.15~1.25 / 70°C~80°C). Take an appropriate amount of talcum powder, starch, etc., add thick paste, mix and dry, and make granules. The obtained granules are added with appropriate amount of auxiliary materials (silicon dioxide, magnesium stearate, microcrystalline cellulose, etc.), mixed uniformly, sieved, and the water content is controlled between 3.0% and 10.0%, and then pressed into tablets and coated to obtain a finished product. The product name is "Sanjin Tablet".

Embodiment 3

[0042] Raw materials: 680g golden cherry root, 360g sarsaparilla, 320g sheep opening, 200g golden sand vine, 200g centella asiatica

[0043] The raw material is decocted with water and extracted twice, the first time is 3 hours, and the second time is 2 hours. The extracted filtrate is placed in a vacuum concentration tank and concentrated into a thick paste (d=1.15~1.30 / 70°C~80°C). The thick paste is conventionally dried, and the water content of the obtained dry paste powder is ≤5%. Take the dry cream powder, add appropriate amount of talcum powder, dry starch, etc., granulate by conventional method, add auxiliary materials (such as silicon dioxide, magnesium stearate, microcrystalline cellulose, etc.) The dosage is controlled between 3.0% and 10.0%, and the capsules are made into capsules through conventional technology, and each capsule is equivalent to 3.5g of the original medicinal material. The product name is "Sanjin Capsule".

[0044] Below, the applicant will use s...

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Abstract

The invention relates to application of a Chinese medicine composition in preparation of a medicament for treating the overhigh level of a urine cell factor or a receptor thereof and Escherichia coli infection. The cell factor or receptor thereof is sIL-2R, IL-6 and IL-8. The Chinese medicine composition is prepared from the following raw materials in percentage by weight: 14-20 percent of cherokee rose root, 6-10 percent of chinaroot greenbrier, 7-10 percent of akebia trifoliata koidz, 3.0-6.5 percent of Japanese climbing fern and 3.2-6.8 percent of centella. The Chinese medicine composition has obvious curative effect on urinary tract infection with overhigh level of urinary sIL-2R, urinary IL-6 and urinary IL-8 and urinary tract infection and lower respiratory tract infection with Escherichia coli as a main pathogenic bacterium.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating excessive levels of urinary cytokines or their receptors and Escherichia coli infection. Background technique [0002] Studies have shown that various cytokines or their receptors play an important role in the body's defense against the invasion of pathogenic microorganisms, and also cause tissue damage. sIL-2R, IL-6, and IL-8 are three common cytokines and cytokine receptors. sIL-2R, the serum soluble interleukin-2 receptor, is a component of the IL-2Ra chain (IL-2Ra) and is expressed on the surface of activated T cells, LPS and IFNγ-stimulated monocytes, and some B cell lines Most scholars believe that IL-2R molecules on the cell surface are produced by proteolysis, and the release of sIL-2R is a characteristic mark of the above-mentioned cell activation. Its expressio...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61P31/04A61P11/00A61P13/00A61P13/02A61P13/08A61P13/12
CPCY02A50/30
Inventor 邹节明
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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