Method for performing industrialized production on moxifloxacin hydrochloride
A technology of moxifloxacin hydrochloride and sodium chloride, applied in the field of industrialized production of moxifloxacin hydrochloride
Active Publication Date: 2011-06-15
NANJING YOKO PHARMA
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This method has never been used in the synthesis of moxifloxacin hydrochloride
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The invention relates to a method for synthesizing moxifloxacin hydrochloride. The method is characterized in that: moxifloxacin hydrochloride is precipitated from solution according to solubility difference of the moxifloxacin hydrochloride in sodium chloride solution with different concentrations so as to fulfill the aim of separation. The method particularly comprises the following steps of: adding sodium chloride into moxifloxacin hydrochloride-containing aqueous solution; stirring to crystallize; filtering; drying; recrystallizing with water; filtering; and drying to obtain the moxifloxacin hydrochloride. The method is simple and convenient in operation; the product has high purity; a single impurity is less than 0.1 percent; the total impurities are less than 0.2 percent; and the method is suitable for industrialized production.
Description
A kind of method of industrialized production moxifloxacin hydrochloride technical field The invention relates to an industrialized method for producing moxifloxacin hydrochloride. Moxifloxacin hydrochloride is a fluoroquinolone antibiotic that can be used to treat infections caused by sensitive bacteria. Formula I technical background Moxifloxacinhydrochloride (Moxifloxacinhydrochloride) is an extended-spectrum quinolone antibiotic developed by Bayer, and its chemical name is: 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[( 4αS,7αS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylate hydrochloride. Its chemical structural formula is shown in Formula 1. Moxifloxacin hydrochloride was first listed in Germany in September 1999, and was approved by FDA in December 1999 for listing in the United States. On the basis of maintaining the excellent activity of fluoroquinolones against gram-negative bacteria in the early stage, the activity against gram-...
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IPC IPC(8): C07D471/04
Inventor 叶海晁阳梁静陈爱萍刘雪曹卫陈雷
Owner NANJING YOKO PHARMA
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