Organotin-oxygen cluster containing ferrocene pyrazole and application of cluster
A technology of ferrocene pyrazolyl and organotin, which is applied in the fields of tin organic compounds, organic chemistry, metallocene, etc., can solve the problems of damaging the immune system of animals, and the low molecular weight organotin compounds are not suitable for anticancer agents, etc. Low, low toxicity, and the effect of improving biological activity
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[0037] The present invention is further explained in detail through the following examples, but it should be noted that the scope of the present invention is not limited by these examples.
[0038] 1. The synthesis of ligand [3-trifluoromethyl-5-ferrocenepyrazole acetic acid (LCOOH)]:
[0039] Weigh 5-ferrocenyl-3-trifluoromethylpyrazole S (6.40g, 0.02mol) and dissolve it in acetonitrile, then weigh t-BuOK (3.36g, 0.03mol) and add it to the above solution, 60 After heating at ℃ for 2h, BrCH 2 COOC 2 H 5 (6.68g, 0.04mol) was dropped into the flask drop by drop, the reaction was carried out for 4 to 5 hours after the dropping, and TLC detection showed that the reaction was basically over. Acetonitrile was distilled off under reduced pressure, and water was added to heat and reflux to hydrolyze the product. After 1.5 hours, the reaction was completed. The mixture was taken out. Under ice bath, diluted HCl (1M) was added dropwise to the above mixture to adjust the pH of the solution to...
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