Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord

A surgical and medical technique used in therapy, spinal cord nerve electrodes, electrotherapy, etc. to solve problems such as providing benefits to patients

Inactive Publication Date: 2011-08-31
CHILDRENS MEDICAL CENT CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, results obtained in a retrospective case series have shown that this treatment provides little benefit to patients

Method used

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  • Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord
  • Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord
  • Medical devices for use in the surgical treatment of hyperproliferative diseases affecting the spinal cord

Examples

Experimental program
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Effect test

Embodiment 1

[0089] Embodiment 1, polypyrrole microtube (mini-tube) manufacture (1)

[0090] Polypyrrole tube scaffolds were formed by electrodepositing erodible PPy onto 250 μm diameter platinum wires at 100 μA for 30 min. see for example figure 2 . After this step, reverse plating was performed at 3V for 5 minutes to enable removal of the scaffold. The current, timing, voltage and other parameters of this embodiment are not intended to be limiting.

Embodiment 2

[0091] The manufacture (II) of embodiment 2, PPy micropipe

[0092] Tubular PPy scaffolds were fabricated by electroplating PPy on conductive wire molds. This technique can be scaled to produce stents of arbitrary length, inner and outer diameter. Also, the plating temperature can be used (see figure 2 ) controls the surface roughness. Extraction of the scaffold from the template was achieved by applying a negative potential in saline solution. This negative potential causes electrochemical reduction and slightly increases the scaffold size. It can then be mechanically detached from the platinum wire mold with light application of force without damage to the material. This technique is an improvement over existing methods that use harsh organics to etch internal lines. For in vivo use, PPy tube scaffolds were formed by electrodeposition of erodible PPy onto platinum wires with a diameter of 250 μm at 100 μA for 40 min, followed by reverse plating at 3 V for 20 s, enablin...

Embodiment 3

[0093] Embodiment 3, single stent manufacture

[0094] A 50:50 poly(lactic-co-glycolic acid) (PLGA) (75%, number average molecular weight, Mn, about 40,000) and a block copolymer of poly(lactic-co-glycolic acid-polylysine) (25%, A mixture of PLGA block Mn about 30,000 and polylysine block Mn about 2000) is made into a single scaffold. PLGA was chosen to achieve a degradation rate of approximately 30-60 days, and functionalized polymers were incorporated to provide possible sites for surface modification. Single scaffolds were fabricated using the salt leaching method: a 5% (wt / vol) solution of the polymer mixture in chloroform was cast on salt in the diameter range of 250-500 μm and the solvent was allowed to evaporate. The salt is then soaked in water to form a single porous polymer layer that can be seeded with stem cells or other agents.

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Abstract

Provided herein are new methods for the treatment of hyperproliferative diseases affecting the spinal cord, including the use of biodegradable polymers to treat spinal cord tumor recessing, i.e., to patch open zones left by spinal tumor removal. Biocompatible polymeric materials are tailored to fill areas previously occupied by tumors, e.g., materials in the form of tubular articles configured for insertion into the spinal column after surgical removal of a tumor. These protective articles may also include medicinal agents that stimulate spinal column neural regeneration, such as medicines or donor neuronal cells such as human neural stem cells, thus assisting patients to recover motorsensory function after spinal tumor surgery.

Description

[0001] Cross References to Related Applications [0002] This application is related to US patent application 60 / 794,986, filed April 25, 2006, and US patent application 11 / 789,538, filed April 25, 2007, the entire contents of which are incorporated herein by reference. technical field [0003] The present application relates generally to medical devices, and more particularly to medical devices used in the surgical treatment of hyperproliferative diseases affecting the spinal cord. Background of the invention [0004] Hyperproliferative diseases of the spinal cord, including spinal tumors and spinal cord tumors, include a variety of different pathological diagnoses, which vary significantly according to the site and age of the patient. The spine and spinal cord can be affected by both primary and metastatic tumors, allowing a wide range of differential diagnosis and treatment options. Spinal cord tumors are usually characterized based on their primary site: epidural, intra...

Claims

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Application Information

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IPC IPC(8): A61N1/00A61K9/22
CPCA61N1/326A61L2430/38A61L27/14A61L27/58A61N1/00A61N1/0551
Inventor R·S·兰格R·赛加尔Y·腾E·伍达德
Owner CHILDRENS MEDICAL CENT CORP
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