Method for refining prolinamide
A technology of proline amide and proline ester, which is applied in the direction of organic chemistry, can solve the problems of product titration content decline, etc., and achieve the effects of not easy racemization, high optical purity and simple method
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Embodiment 1
[0029] Embodiment 1: Preparation of L-proline methyl ester hydrochloride.
[0030] Pump 500L of methanol into the reactor, and drop in 100 kg of L-proline. Stir and cool to 0~-10°C, and add 136 kg of thionyl chloride dropwise under temperature control. After dropping, the temperature was raised to reflux for 1 to 2 hours. Methanol was concentrated under reduced pressure to obtain a yellow oil.
Embodiment 2
[0031] Embodiment 2: Preparation of D-proline methyl ester hydrochloride.
[0032] Pump 500L of methanol into the reactor, and drop in 100 kg of D-proline. Stir and cool to 0~-10°C, and add 136 kg of thionyl chloride dropwise under temperature control. After dropping, the temperature was raised to reflux for 1 to 2 hours. Methanol was concentrated under reduced pressure to obtain a yellow oil.
Embodiment 3
[0033] Embodiment 3: Preparation of D-proline ethyl ester hydrochloride.
[0034] Pump 500L of ethanol into the reactor, and drop in 100 kg of D-proline. Stir and cool to 0~-10°C, and add 136 kg of thionyl chloride dropwise under temperature control. After dropping, the temperature was raised to reflux for 1 to 2 hours. Ethanol was concentrated under reduced pressure to obtain a yellow oil.
[0035] step 2
[0036]
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