Method for preparing compound Chinese medicine microcapsules

A compound traditional Chinese medicine and microcapsule technology, applied in the field of medicine, can solve the problems of bad smell, low bioavailability and strong hygroscopicity of traditional Chinese medicine, and achieve the effects of easy mass production, wide source of raw materials and mild preparation conditions

Inactive Publication Date: 2011-09-21
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many problems in traditional Chinese medicine preparations: (1) the bioavailability of current traditional Chinese medicine preparations is very low, resulting in a large amount of waste of active ingredients of traditional Chinese medicine; Problems such as splinters and mildew lead to unnecessary loss of resources during storage and transportation; (3) a considerable part of traditional Chinese medicine has bad smell, which is difficult for patients to accept; (4) the release of traditional Chinese medicine is very unstable, and it is difficult to achieve good results. Efficacy
As for the research on the microencapsulation of compound Chinese medicine, because of its complex composition, there is no report on the preparation of microcapsules with compound Chinese medicine as the core material.

Method used

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  • Method for preparing compound Chinese medicine microcapsules
  • Method for preparing compound Chinese medicine microcapsules
  • Method for preparing compound Chinese medicine microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Prepare a 1wt% sodium alginate solution with distilled water at 60°C and stir at 2000rpm for 30 minutes to obtain a uniform and transparent solution.

[0026] (2) Capsule core: Compound Yishen Mixture, for chronic renal failure, weighed a certain quality of rhubarb, astragalus, salvia, rehmannia, poria, boiled with distilled water to extract Chinese medicine.

[0027] (3) Add the compound Chinese medicine extract to the sodium alginate solution, the volume ratio of the two is 1:4, and magnetically stir to make it evenly mixed.

[0028] (4) Prepare a calcium chloride solution with a mass concentration of 8% and adjust the pH to 5.87 with acid.

[0029] (5) Connect the positive electrode of the high-voltage generator to the syringe needle, and the negative electrode to the bottom of the measuring cup containing the calcium chloride solution, and adjust the voltage to 8000V.

[0030] (6) Place the sodium alginate-compound traditional Chinese medicine mixture in the needle of the...

Embodiment 2

[0034] (1) Prepare a 1wt% sodium alginate solution with distilled water at 60°C and stir at 2000rpm for 30 minutes to obtain a uniform and transparent solution.

[0035] (2) Capsule core: liquid flavor.

[0036] (3) Add flavor to the sodium alginate solution, the volume ratio of the two is 1:1, add surfactant PVP according to the addition ratio of 0.5%-2.5% (W / V), and magnetically stir for 40 minutes to make it evenly mixed.

[0037] (4) Prepare a calcium chloride solution with a mass concentration of 5% and adjust the pH to 5.87 with acid.

[0038] (5) Connect the positive pole of the high-voltage generator to the syringe needle, and the negative pole to the bottom of the measuring cup containing the calcium chloride solution, and adjust the voltage to 6000V.

[0039] (6) Place the sodium alginate-flavor mixture in the needle of the syringe, push the piston handle of the syringe by the micro-syringe pump, and drop the sodium alginate-flavor mixture into the chlorination with a mass con...

Embodiment 3

[0043] (1) Prepare a 1wt% sodium alginate solution with distilled water at 60°C and stir at 2000rpm for 30 minutes to obtain a uniform and transparent solution.

[0044] (2) Capsule core: liquid flavor.

[0045] (3) Add flavor to the sodium alginate solution, the volume ratio of the two is 1:1, add surfactant PVP according to the addition ratio of 0.5%-2.5% (W / V), and magnetically stir for 40 minutes to make it evenly mixed.

[0046] (4) Prepare a calcium chloride solution with a mass concentration of 5%, and adjust the pH to 7.5 with alkali.

[0047] (5) Connect the positive electrode of the high-voltage generator to the syringe needle, and the negative electrode to the bottom of the measuring cup containing the calcium chloride solution, and adjust the voltage to 4000V.

[0048] (6) Place the sodium alginate-flavor mixture in the needle of the syringe, push the piston handle of the syringe by the micro-syringe pump, and drop the sodium alginate-flavor mixture into a chlorinated soluti...

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Abstract

The invention relates to a method for preparing compound Chinese medicine microcapsules, which comprises the following steps: mixing and emulsifying solution of sodium alginate and extract solution of a compound Chinese medicine according to a certain ratio; connecting a positive pole of a high-pressure generator with a needle of an injector, and placing the negative pole of the high-pressure generator at the bottom of solution of calcium chloride; and dripping the emulsified solution into the solution of calcium chloride by a microfluidic injection pump at a constant speed, dispersing and standing for 20 to 40 minutes, washing, and drying to obtain the microcapsules with a particle size smaller than 1,000 mu m. In the method provided by the invention, the raw materials are widely available, the price is low, and the large-scale production is easy; and the capsule wall thickness, size, shape and loading capacity of the obtained microcapsules can be controlled.

Description

Technical field [0001] The invention relates to a method for preparing compound Chinese medicine microcapsules, and belongs to the technical field of medicine. Background technique [0002] Chinese medicine is a treasure of traditional medicine and traditional culture in our country. It has made great contributions to the health of the Chinese nation and the people of the world for thousands of years. However, there are many problems with traditional Chinese medicine preparations: (1) The current bioavailability of traditional Chinese medicine preparations is very low, resulting in a large amount of waste of active ingredients in Chinese medicine; (2) Chinese traditional Chinese medicine tablets, pills, and granules are mostly hygroscopic and easy Problems such as cracks and mildew caused unnecessary loss of resources during storage and transportation; (3) A considerable part of Chinese medicines have bad smells, which are difficult for patients to accept; (4) The release of tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/36
Inventor 田卫群徐迎张迪李燕徐怡
Owner WUHAN UNIV
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