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Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof

A composition and technology for pelvic inflammatory disease, applied in the field of traditional Chinese medicine composition for treating pelvic inflammatory disease and its preparation, can solve problems such as difficulty in antibiotics, lack of adhesion-relieving and pain-relieving effects of antibiotics, poor effect of fibrous tissue and connective tissue, etc.

Inactive Publication Date: 2012-06-27
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current Western medicine treatment for this disease mainly starts from two aspects: that is, the application of antibiotics, which aims to eliminate the cause of pathogenic microorganisms, but for chronic pelvic inflammation, due to tissue adhesions and local circulation disorders, it is difficult for antibiotics to penetrate into the local area. It has poor effect on eliminating fibrous tissue and connective tissue infiltrated by inflammation, and antibiotics do not have the effect of relieving adhesion and analgesia, so chronic pelvic inflammatory disease is treated with antibiotics alone, and the curative effect is not satisfactory; in addition, the application of hormones, α-chymotrypsin , placental tissue fluid to reduce inflammation, anti-fibrosis and granulation tissue hyperplasia, and enhance the body's immunity, all have certain limitations and side effects
There are many Chinese patent medicines in the treatment of pelvic inflammatory disease in traditional Chinese medicine, but most of them have unstable curative effect, low cure rate and easy recurrence

Method used

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  • Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof
  • Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof
  • Traditional Chinese drug composition for treating pelvic inflammatory disease, preparation method, application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation of capsule.

[0042] According to the raw material ratio in Table 1 and the conventional method of capsule dosage form, it is prepared into capsules, and the specific methods are as follows:

[0043] Take 10 parts of curcuma and 25 parts of angelica, and use supercritical CO 2 Extract for 1 hour, extraction temperature is 20°C, pressure is 20MPa, and entrainer is 95% ethanol to obtain a supercritical extract, which is clathrated with β-cyclodextrin by the saturated aqueous solution method, and continuously stirred for 3 hours under the condition of 30°C and heat preservation, and the stirring speed is 80 rpm, refrigerated for 24 hours, suction filtered, and dried at 40°C to obtain β-cyclodextrin inclusion compound, which was stored separately;

[0044] The above supercritical CO 2 After the extraction process, the dregs and 6 parts of safflower, 40 parts of Motherwort, 6 parts of Yanhusuo, 10 parts of Wuyao, 10 parts of Dihuang, 20 parts ...

Embodiment 2

[0045] Embodiment 2: Preparation of granules.

[0046] According to the ratio of raw materials in Table 1 and the conventional method of granule dosage form, it is prepared into granules, and the specific method is as follows:

[0047] Take 15 parts of curcuma and 20 parts of angelica, and use supercritical CO 2Extracted for 2 hours, the extraction temperature was 40°C, the pressure was 30MPa, and the entrainer was 95% ethanol to obtain a supercritical extract, which was clathrated with β-cyclodextrin by the saturated aqueous solution method, and stirred continuously for 4 hours under the condition of 50°C heat preservation, and the stirring speed was 100 rpm, refrigerated for 36 hours, suction filtered, and dried at 45°C to obtain β-cyclodextrin inclusion compound, which was stored separately;

[0048] The above supercritical CO 2 After the extraction process, 8 parts of medicinal dregs and safflower, 30 parts of Motherwort, 8 parts of Corydalis Corydalis, 8 parts of Wuyao,...

Embodiment 3

[0049] Example 3: Preparation of tablets.

[0050] Prepare by the raw material proportioning of table 1 and tablet dosage form conventional method, be prepared into tablet, concrete method is as follows:

[0051] Take 20 parts of curcuma and 15 parts of angelica, and use supercritical CO 2 Extracted for 3 hours, the extraction temperature was 60°C, the pressure was 40MPa, and the entrainer was 95% ethanol to obtain a supercritical extract, which was clathrated with β-cyclodextrin by the saturated aqueous solution method, and stirred continuously for 5 hours under the condition of 70°C heat preservation, and the stirring speed was 120 rpm, refrigerated for 48 hours, suction filtered, dried at 50°C, β-cyclodextrin inclusion complex, stored separately;

[0052] The above supercritical CO 2 After the extraction process, 10 parts of medicinal dregs and safflower, 20 parts of Motherwort, 10 parts of Corydalis Corydalis, 6 parts of Wuyao, 20 parts of Dihuang, 10 parts of Polygonum ...

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Abstract

The invention discloses a traditional Chinese drug composition for treating pelvic inflammatory disease (PID). The traditional Chinese drug composition is prepared from the following raw materials, by weight, 10-20 parts of blue turmeric rhizome, 15-25 parts of Chinese angelica, 6-10 parts of safflower, 20-40 parts of common motherwort herb, 6-10 parts of yanhusuo tuber, 6-10 parts of combined spicebush root, 10-20 parts of aahesive rehmannia root tuber, 10-20 parts of giant knotweed rhizome, 10-20 parts of common knotweed herb, 10-20 parts of asiatic plantain seed. The invention further discloses a preparation method for preparing the traditional Chinese drug composition, and an application of the traditional Chinese drug composition. The traditional Chinese drug composition provided by the present invention has advantages of activating blood and dissolving stasis, clearing heat and removing dampness, and can be used for treating the PID.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating pelvic inflammatory disease, a preparation method and application thereof. Background technique [0002] Pelvic inflammatory disease refers to the inflammatory damage of the female upper reproductive tract and its adjacent structures. Chronic pelvic inflammatory disease is caused by untreated acute pelvic inflammatory disease or delayed treatment. Pelvic inflammatory disease is a common and frequently-occurring disease in gynecological clinics, and has a high recurrence rate. In the United States, there are about 1 million patients with pelvic inflammatory disease every year, of which about 250,000 women are hospitalized for pelvic inflammatory disease, and about one quarter of the patients with pelvic inflammatory disease relapse, forming chronic pelvic inflammatory disease. There are no de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/00A61K47/48A61P15/00
Inventor 陈军霞卞凌
Owner NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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