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Method for preparing extract fraction reinforced with ginsenosides Rg1 or Rb1 from ginseng

A technology of ginsenosides and extracts, which is applied in the field of extract fragments fortified with ginsenoside Rg1 or Rb1 prepared from ginseng, which can solve the problems of different and ineffective effects

Active Publication Date: 2011-09-21
CJ WELLCARE CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And, in the composition that comprises ginseng extract, according to the ratio of the ginsenoside Rb1 / Rg1 that contains in the extract, can show different effect, in addition, because ginsenoside Rb1 and Rg1 have the opposite effect, can't get from Effectively obtain the effect of each saponin in ginseng extract
In particular, there are disadvantages in health drinks that people who are not under the professional supervision of medical staff and who do not have special diseases like to drink because they may drink drinks that have unintended effects without knowing it.

Method used

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  • Method for preparing extract fraction reinforced with ginsenosides Rg1 or Rb1 from ginseng
  • Method for preparing extract fraction reinforced with ginsenosides Rg1 or Rb1 from ginseng
  • Method for preparing extract fraction reinforced with ginsenosides Rg1 or Rb1 from ginseng

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0034] Experimental Example 1: Preparation of Alcohol Extract of Ginseng

[0035] Add 70% alcohol to 1Kg dried tail ginseng with 15 times of the sample weight, carry out three extractions at 70° C. and then filter, each extraction time is 24 hours. Also, alcohol extracts of ginseng were prepared by the same method using 60% and 80% alcohol.

[0036] The contents of ginsenosides Rg1 and Rb1 in the alcohol extract of ginseng obtained by the above method were respectively measured by high performance liquid chromatography (HPLC). The results are shown in Table 1.

[0037] Table 1

[0038]

[0039] As shown in the above results, the content of ginsenoside Rg1 and Rb1 in the extract of 60-80v / v% alcohol is generally higher, especially when using 60-70v / v% alcohol, the content of ginsenoside Rg1 and Rb1 The highest content.

experiment example 2

[0040] Experimental Example 2: Preparation of Ginseng Extract Using 70v / v% Alcohol

[0041] Using the same method as above Experimental Example 1, the alcohol extract of ginseng was prepared, wherein the concentration of alcohol was fixed at 70v / v%, and the extraction conditions were changed as shown in the following table 2. After the alcohol extract of ginseng was prepared, The contents of ginsenosides Rg1 and Rb1 were determined by high performance liquid chromatography (HPLC). The results are shown in Table 2.

[0042] Table 2

[0043]

[0044] According to the above experimental results, when using 70v / v% alcohol for extraction, the temperature conditions are different, the content of ginsenoside Rg1 and Rb1 is slightly different, especially the content of Rb1 is significantly increased at 70°C. In addition, the total content of ginsenosides Rg1 and Rb1 was the highest at 70°C.

[0045] And, for the treatment time, the content of ginsenosides Rg1 and Rb1 increased...

Embodiment 1

[0047] Embodiment 1: the adsorption process of macroporous adsorption resin HP-20

[0048] The alcohol extract of ginseng extracted at 70° C. for 24 hours in Experimental Example 1 was heated and concentrated to 80 brix. Afterwards, add the water that weight is 5 times of this concentrate, after fully diluting, it is introduced into macroporous adsorption resin HP-20 resin, has adsorbed saponin component. Thereafter, distilled water about 5 times the capacity of the above-mentioned resin was continuously introduced to remove unadsorbed components.

[0049] Afterwards, in order to remove non-saponin components, 20v / v% alcohol about 5 times the volume of the resin was first introduced, and then the alcohol concentration was adjusted in order to obtain fragments of ginsenosides to be fragmented. The elution began when the alcohol concentration was 30v / v%, and the fortified fragment of ginsenoside Rg1 was obtained when the alcohol concentration was 40v / v%. And, the elution sta...

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Abstract

The present invention provides a method for preparing an extract fraction reinforced with ginsenoside Rg1 or Rb1 from ginseng. The method for preparing an extract fraction reinforced with ginsenoside Rg1 comprises the steps of: concentrating a spirit extract of ginseng and then adsorbing the extract diluted in water by adding to an adsorption resin; passing distilled water through the adsorption resin, then eluting and removing unadsorbed ingredients; and adding 30-40 v / v% spirits to the adsorption resin to obtain an eluate. The method for preparing an extract fraction reinforced with ginsenoside Rb1 comprises the steps of: concentrating a spirit extract of ginseng and then adsorbing the extract diluted in water by adding to an adsorption resin; passing distilled water through the adsorption resin, then eluting and removing unadsorbed ingredients; and adding 50-80 v / v% spirits to the adsorption resin and then eluting.

Description

technical field [0001] The present invention relates to a method for preparing extract fragments fortified with specific saponin components using ginseng, and more particularly to preparing ginsenoside Rg1 with anti-fatigue effect or ginsenoside with calming effect among the saponins in ginseng Method for extract fragments of Rb1 fortified. Background technique [0002] Ginseng (Panax ginseng C.A.Mayer) is botanically a plant belonging to the genus Panax of the family Araliaceae. It has been widely used as a medicinal material in China since BC, and has been widely used in trade and medicinal materials in Korea since the Three Kingdoms era. , At present, it is widely used in various fields as Chinese herbal medicine or health food. [0003] As its special ingredient, ginseng contains 3% to 6% of a saponin-like substance called ginsenoside, which is a representative physiologically active substance of ginseng, and is divided into panaxadiol type according to its structure. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258
CPCA61K36/258A61P25/20A61K2236/37A61K2236/55
Inventor 金英恩金杜庚徐溶基李琎熙
Owner CJ WELLCARE CORPORATION
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