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Composite armadillidium vulgare extract and preparation method and application thereof to pain relieving medicaments

A technology of compound sarcophagus and extract, which is applied in the field of compound sarcophagus extract and its preparation, and can solve the problems of not being easy to use, adverse reactions of the cardiovascular system, improper dosage control, etc.

Active Publication Date: 2012-12-19
JILIN TONGHUA BOXIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, it has an inhibitory effect on the respiratory center. Once the dosage is improperly controlled during medication, it is easy to cause poisoning, respiratory depression and death.
Therefore, the daily application of neuropathic analgesics is greatly restricted, and most of them are controlled drugs, which are generally not easy to use
The other category is non-steroidal anti-inflammatory drugs with analgesic, antipyretic, and anti-inflammatory effects, which mainly act on the peripheral nervous system, and are effective for inflammation, rheumatic diseases, pain caused by soft tissue injuries, and various dull pains (such as headaches) , toothache, etc.) are effective, but there are usually side effects of gastrointestinal damage, liver damage, and kidney damage. Long-term use can cause aplastic anemia, neutropenia or thrombocytopenia, and adverse reactions to the cardiovascular system, which seriously damages the patient health

Method used

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  • Composite armadillidium vulgare extract and preparation method and application thereof to pain relieving medicaments
  • Composite armadillidium vulgare extract and preparation method and application thereof to pain relieving medicaments
  • Composite armadillidium vulgare extract and preparation method and application thereof to pain relieving medicaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Ratwort, Corydalis Corydalis and Xu Changqing Compound Extract

[0090]Take 1 kg of Corydalis Corydalis, 1 kg of Corydalis Corydalis, and 1 kg of Xu Changqing, mix the above-mentioned Corydalis Corydalis and Xu Changqing, add 10 kg of water, extract 3 times at 100 ° C, 1.5 hours each time, and combine the extracts; take the above Corydal Corydalis, add 4 times the amount of 70 % ethanol, heated and refluxed for 3 times, each time for 1h, the extract was filtered, and the filtrate was collected. Combine the filtrates, concentrate to 10% of the original volume, add 95% ethanol to make the ethanol concentration 60%, precipitate, take the supernatant, concentrate and recover the ethanol, spray dry the extract to obtain a dry powder.

Embodiment 2

[0092] Alcohol Extract of Ratwort, Corydalis Corydalis, Xu Changqing Compound

[0093] Weighing mouse woman: 1kg, Yanhusuo: 0.8kg, Xu Changqing: 0.7kg

[0094] Mix the above-mentioned fenugreek, Corydalis Corydalis, and Xu Changqing, add 12 times the weight of 80% ethanol, reflux extraction for 3 times, each time for 1 hour, and combine the extracts. Concentrate under reduced pressure to obtain the ethanol extracts of the compound recipe of sarcocarpus, Corydalis Corydalis and Xu Changqing.

Embodiment 3

[0096] Ratwort, Corydalis Corydalis and Xu Changqing Compound Extract

[0097] Take 1 kg of Corydalis 1 kg, 0.7 kg of Corydalis Corydalis, and 1 kg of Xu Changqing, mix the above-mentioned Corydalis Corydalis and Xu Changqing, add 15 kg of water, extract 3 times at 100 ° C, 2.0 hours each time, and combine the extracts; 70% ethanol, heated and refluxed for 3 times, 1 hour each time, filtered the extract, and collected the filtrate. Combine the filtrates, concentrate to 10% of the original volume, add 95% ethanol to make the ethanol concentration 60%, precipitate, take the supernatant, concentrate and recover the ethanol, spray dry the extract to obtain a dry powder.

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Abstract

The invention discloses a composite armadillidium vulgare extract, a preparation method thereof and application thereof to pain relieving medicaments. The method comprises the followings steps of: decocting rmadillidium vulgare, rhizoma corydalis and paniculate swallowwort root which are in compatibility of medicines and serve as base formula, with water or ethanol, condensing the liquid supernatant, adding ethanol into the liquid supernatant, after sedimentation, condensing the liquid supernatant, and performing spray dehydration on the condensed liquid supernatant to obtain dry powder, wherein the base formula also can be mixed with one or more traditional Chinese medicines to be prepared into a composite preparation and then the dry powder is prepared by the same method; and adding medically acceptable auxiliary materials into the dry powder to prepare the dry powder into any oral or external formulation in pharmaceutics. The composite armadillidium vulgare extract has the advantages of scientific compatibility of medicines, obvious synergistic effect among the rmadillidium vulgare, rhizoma corydalis and paniculate swallowwort root, reasonable preparation process, no damage to the active ingredients of the Chinese medicinal raw materials, no toxic and side effects, no addiction, no medicament resistance, and obvious pain-relieving effect on various pains, particularly on cancer pain.

Description

Technical field [0001] The present invention provides a compound mouse extraction and preparation method. At the same time, its application in analgesic drugs is also published, which belongs to the method of Chinese medicine extraction and traditional Chinese medicine preparation technology. Background technique [0002] There are countless patients who are plagued by pain every year. In recent years, due to the development of medical level, although many developed countries have made great progress in the field of pain treatment, 40%of patients with acute pain in these countries have not obtained.Proper treatment.The number of patients who have not received effective treatment will be higher.Due to the lack of understanding of limited medical resources and pain in pain, the gap is greater than developed countries. Therefore, the current level of treatment is far from meeting the needs of patients. [0003] At present, medical institutions mainly use drug control for the treatme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P29/02A61K35/64
Inventor 滕利荣王贞佐田野沈畏宋静静吴凌赵敏孟庆繁逯家辉
Owner JILIN TONGHUA BOXIANG PHARMA