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Use of indole-2,3-dione in preparation of medicines for preventing sperm malformation

A technology for sperm deformity and indole, applied in the field of application of indole-2,3-dione in the preparation of anti-sperm deformity drugs

Inactive Publication Date: 2011-10-12
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to antibiotic treatment for the etiology, drug treatment usually can only slightly improve the sperm deformity in some patients by supplementing vitamin A, vitamin E and zinc sulfate. Currently, there is no clear drug to treat sperm deformity

Method used

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  • Use of indole-2,3-dione in preparation of medicines for preventing sperm malformation
  • Use of indole-2,3-dione in preparation of medicines for preventing sperm malformation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of tablet

[0019] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add indole-2,3-dione, heat and dissolve at 60°C under the action of a magnetic stirrer, and recrystallize at room temperature to obtain needle-shaped orange red Crystallization, recrystallization 3 times according to the above operation. The crystals were pulverized and passed through an 80-mesh sieve, and 100 mg of indole-2,3-dione, 100 mg of lactose, and 295 mg of starch were weighed and mixed evenly, granulated by a wet method, dried, mixed with 5 mg of magnesium stearate after sizing, and compressed into tablets. into tablets each weighing 500 mg.

Embodiment 2

[0020] Embodiment 2: the preparation of capsule

[0021] Mix ultrapure water and absolute ethanol at a ratio of 1:5, add indole-2,3-dione, heat and dissolve at 60°C under the action of a magnetic stirrer, and recrystallize at room temperature to obtain needle-shaped orange red Crystallization, recrystallization 3 times according to the above operation. The crystals were pulverized and passed through an 80-mesh sieve, and 100 mg of indole-2,3-dione, 100 mg of lactose, and 295 mg of starch were weighed and mixed evenly, and filled into capsules to make capsules with a net weight of 500 mg each.

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Abstract

The invention relates to the use of indole-2,3-dione in preparation of medicines for preventing indole-2,3-dione. The indole-2,3-dione is natural or artificially synthesized, is low in toxicity and has good sperm malformation preventing effect.

Description

technical field [0001] The invention relates to the application of indole-2, 3-dione (indole-2, 3-dione) in the preparation of antisperm deformity drugs. Background technique [0002] In recent years, due to environmental pollution, the influence of drugs and the influence of various electromagnetic waves and radiation, the decline in the quality of male sperm has become a common disease in andrology. According to statistics, 40% of infertile men are abnormal sperm. Normal sperm are tadpole-shaped in shape, with three parts: head, body, and tail. For males with normal fertility, the sperm in normal form should be more than 80%. If the deformity rate exceeds 20%, it can cause infertility, and the increase in deformed sperm will cause infertility, habitual abortion, fetal deformity, and newborns. The occurrence of mentally handicapped and so on. [0003] The causes of teratospermia include genitourinary tract infection, mumps complicated by orchitis, epididymal tuberculosis...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P15/08
Inventor 岳旺石振艳杨志宏鞠传霞金景玉张芳
Owner QINGDAO UNIV
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