Increasing pregnancy rates

a technology of increasing pregnancy rate and increasing which is applied in the field of formulation, can solve the problems of rapid destruction of the cl, cessation of progesterone production, and approximately 50% of the cows receiving these treatments becoming pregnant, so as to increase the probability of an animal becoming pregnant and increase the number of animals

Inactive Publication Date: 2009-02-05
PARNELL TECH
View PDF1 Cites 25 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0299]The present invention also provides a formulation according to the first aspect or made by the process of the third aspect, or a unit dose according to the second aspect or made by the process of the fourth aspect, when used in a hormone intervention programme. The programme may be for increasing the number of an

Problems solved by technology

Despite the extensive research into these procedures, a disadvantage with them remains that only approximately 50% of the cows receiving these treatments become pregnant.
These feedback systems are complex because the ovaries contain a limited (finite) number of follicles.
However, if circulating progesterone levels are low (e.g. at proestrus), there is a temporary reversal of the negative oestradiol feedback loop and a large surge of LH is released from the pituitary.
In the absence of pregnancy, the combined effect of the lack of ongoing tropism plus the release of prostaglandin by the endometrium results in rapid destruction of the CL and cessation of progesterone production.
The successful implementation of a synchrony programme within a herd is challenging.
Prostaglandin is not effective during t

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Increasing pregnancy rates
  • Increasing pregnancy rates
  • Increasing pregnancy rates

Examples

Experimental program
Comparison scheme
Effect test

example 1

Improvements to the OVsynch Protocol

1. Introduction

[0383]The ‘OVsynch’, or GPG, oestrus synchronization protocol uses a combination of GnRH and prostaglandin, followed by fixed time insemination (FTAI). The usefulness of the protocol in whole herd synchrony programmes has been demonstrated in studies around the world and in a local field study conducted by Parnell Laboratories in conjunction with dairy veterinarians in Victoria in 2001. The application of OVsynch to the treatment and synchronization of anovulatory anoestrus (M) cows is supported by a small body of published work and the results of a major study in pasture-based cows in Australia and New Zealand conducted by Parnell Laboratories.

[0384]There is much discussion in the literature as to how to increase the number of cows that become pregnant as a consequence of the oestrus synchronization programmes.

[0385]A preliminary study was conducted in order to assess the possible synergistic effect of incorporation of a progestero...

example 2

Formulation of Product

[0418]In order to manufacture the product, it would be ideal if the GnRH and the progesterone were in the same injection. In order to achieve this, it is necessary to devise means by which to formulate two very different molecules into a stable formulation. GnRH is a decapeptide, i.e. a short protein containing ten amino acids. This material is particularly soluble in aqueous solutions. Progesterone on the other hand is a hydrophobic molecule that is soluble in non-aqueous solvents but not soluble in aqueous solvents.

[0419]A further requirement of the final formulation is that it be possible to sterilise the material by filtration through 0.2 μm filters. Neither the progesterone nor the GnRH can be sterilised by autoclaving as they are unstable to heat. In order to achieve a stable formulation, a large number of variables have to be tested.

[0420]The following examples illustrate the types of formulation that may be suitable.

Formulation 1

[0421]

MaterialmgProgeste...

example 3

Further Formulations

Process for all Formulations:

[0429]1) The Gonadorelin acetate was dissolved in the water.[0430]2) The first quantity of N-methyl-2-pyrrolidone was added to the solution obtained in step 1.[0431]3) The progesterone, benzyl alcohol and Plasdone C15 were dissolved in the solution obtained in step 2.[0432]4) Additional N-methyl-2-pyrrolidone was added was added to volume.

Materialmg(Kg)Progesterone BP / USP250125Gonadorelin Acetate0.10.05Benzyl Alcohol2010Plasdone C155025water5025N-methyl-2-pyrrolidone1727863.5N-methyl-2-pyrrolidoneTo 2.0 mLto 100 LProgesterone BP / USP250125Gonadorelin Acetate0.10.05Benzyl Alcohol2010Plasdone C155025water2512.5N-methyl-2-pyrrolidone1752876N-methyl-2-pyrrolidoneTo 2.0 mLto 100 LProgesterone BP / USP250125Gonadorelin Acetate0.10.05Benzyl Alcohol2010Plasdone C155025water105N-methyl-2-pyrrolidone1766883N-methyl-2-pyrrolidoneTo 2.0 mLto 100 L

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Densityaaaaaaaaaa
Densityaaaaaaaaaa
Densityaaaaaaaaaa
Login to view more

Abstract

The invention relates to a stable formulation for controlling oestrus in a subject. The formulation comprises Gonadotrophin Releasing Hormone or an acceptable salt or analogue thereof, progesterone or an analogue thereof, and an acceptable carrier.

Description

TECHNICAL FIELD[0001]The present invention relates to a formulation for use in increasing the rate of pregnancy in an animal.BACKGROUND OF THE INVENTION[0002]Throughout the dairy industry worldwide, control of the ovulation cycle in cows is essential to ensure a regular supply of lactating cows. Reproductive performance remains an area of dairy management that must be optimised to ensure continued productivity and a sustainable operation. A cow must be pregnant by 85 days postpartum in order to achieve optimum milk production and calve every 12½ months.[0003]Management of reproduction is achieved by treatment of the cows with a variety of hormone interventions at particular times followed by artificial insemination. There are several hormone intervention systems in use throughout the world. Despite the extensive research into these procedures, a disadvantage with them remains that only approximately 50% of the cows receiving these treatments become pregnant. The reasons for this inc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K38/09
CPCA61K31/57A61K38/09A61K2300/00A61P5/24
Inventor BELL, ALAN RICHARDSHEPHARD, RICHARD W.IEMMA, SALVATORESTAJIC, VLADIMIR
Owner PARNELL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap