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Application of C10orf116 genes in preparing medicament for improving insulin sensitivity of adipose tissue

A 1.c10orf116, insulin sensitivity technology, applied in the field of genetic engineering

Inactive Publication Date: 2013-03-13
郭锡熔 +8
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But how the gene is related to insulin sensitivity is unknown

Method used

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  • Application of C10orf116 genes in preparing medicament for improving insulin sensitivity of adipose tissue
  • Application of C10orf116 genes in preparing medicament for improving insulin sensitivity of adipose tissue
  • Application of C10orf116 genes in preparing medicament for improving insulin sensitivity of adipose tissue

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Embodiment 1

[0017] 1 Materials and methods

[0018] 1.1 Test material

[0019] 1.1 Test material

[0020] pcDNA required for this assay TM 3.1 / myc-His(-)A plasmid was purchased from Invitrogen, USA; hC10orf116-pcDNA TM 3.1 / myc-His(-)A eukaryotic expression vector was constructed by our experimental group; Easy was purchased from Promega, USA; The plasmid vector was constructed by our experimental group; 2-deoxy-D-3[H]Glucose was purchased from Amersham, UK; the RNA extraction agent TRIzoL TM Reagent was purchased from Invitrogen Company of the United States; reverse transcription reagent was purchased from Promega Company of the United States; Advantage TM 2 The PCR kit was purchased from Takara Company of Japan; the TA vector was purchased from Promega Company of the United States; the Master Mix in real-time fluorescent quantitative PCR was purchased from ABI Company of the United States; the primers were synthesized by Invitrogen Company of the United States.

[0021] 1.2 (1)...

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Abstract

The invention belongs to the field of genetic engineering, and discloses the application of C10orf116 genes in preparing a medicament for improving the insulin sensitivity of an adipose tissue. The application of C10orf116 genes in preparing a medicament for improving the insulin sensitivity of an adipose tissue and / or a medicament for promoting the glucose absorption of the adipose tissue disclosed by the invention provides a new technical scheme for preparing a medicament for improving the insulin sensitivity of an adipose tissue and / or a medicament for promoting the glucose absorption of the adipose tissue.

Description

technical field [0001] The invention belongs to the field of genetic engineering and relates to the application of C10orf116 gene in the preparation of drugs for improving insulin sensitivity of adipose tissue. Background technique [0002] Diabetes is a metabolic disease that seriously endangers human health and quality of life. At present, type 2 diabetes is the main type of diabetes in my country, accounting for more than 90% of the diabetic population, and the trend of younger patients is becoming more and more obvious. Its serious harm and increasing morbidity among young people and children have attracted widespread attention from scholars all over the world, and it has become an important research direction in the medical field. [0003] The pathogenesis of diabetes mainly has two aspects: one is insufficient insulin secretion, and the other is insulin resistance. Obesity, especially central obesity, is an important risk factor for insulin resistance. Adipocytes ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00A61P3/10A61P5/48
Inventor 郭锡熔朱春倪毓辉彭宇竹刘晓梅王欣池霞邱洁曹新国
Owner 郭锡熔
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