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Medicine composition for treating diabetes mellitus

A composition and a technology for diabetes, applied in the field of medicine, can solve the problems of undiscovered arctigenin and rosiglitazone, and achieve the effects of reducing the level of glycated serum protein, significantly retinopathy, and improving insulin resistance

Active Publication Date: 2011-10-19
江苏叠石桥家纺产业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, through the search of public publications at home and abroad, it has been found that arctigenin and rosiglitazone or its pharmaceutically acceptable salts have been reported in the prior art to treat diabetes and its complications alone, but arctigenin has not been found so far. Related reports of rosiglitazone or its pharmaceutically acceptable salt as a compound drug in the treatment of diabetes and its complications

Method used

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  • Medicine composition for treating diabetes mellitus
  • Medicine composition for treating diabetes mellitus
  • Medicine composition for treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: tablet

[0025]

[0026]

[0027] Preparation process: Pass rosiglitazone hydrochloride and arctigenin in the prescription through an 80-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose through an 80-mesh sieve, and weigh the prescription amount of rosiglitazone hydrochloride and arctigenin Mix aglycon with low-substituted hydroxypropyl cellulose and microcrystalline cellulose evenly, add 2% hydroxypropyl methylcellulose solution to make granules, dry at 60°C, granulate with a 16-mesh sieve, and add the prescribed amount of Magnesium stearate is mixed evenly and compressed into tablets.

Embodiment 2

[0028] Embodiment 2: tablet

[0029]

[0030] Preparation process: Pass rosiglitazone maleate and arctigenin in the prescription through an 80-mesh sieve, microcrystalline cellulose and low-substituted hydroxypropyl cellulose through an 80-mesh sieve, and weigh the prescription amount of rosiglitazone maleate Litazone, arctigenin, low-substituted hydroxypropyl cellulose, and microcrystalline cellulose are mixed evenly, and an appropriate amount of 2% hydroxypropyl methylcellulose solution is added to make granules, dried at 60°C, granulated with a 16-mesh sieve, and added to the dry granules Add the prescribed amount of magnesium stearate, mix well, and compress into tablets.

Embodiment 3

[0031] Embodiment 3: capsules

[0032] formula:

[0033]

[0034] Appropriate amount of 5% polyvinylpyrrolidone aqueous solution

[0035] Preparation method: pass rosiglitazone mesylate, arctigenin and auxiliary materials through 80-mesh sieve respectively for later use. Weigh rosiglitazone mesylate, lactose, starch, and L-HPC according to the prescription, mix them uniformly by the method of equal increase, add 5% polyvinylpyrrolidone aqueous solution to make soft material, pass through a 24-mesh sieve to granulate, and store at 60°C After drying, pass through a 24-mesh sieve for granulation. The arctigenin and the microcrystalline cellulose are evenly mixed, granulated by a dry method, and granulated through a 24-mesh sieve. After the above two kinds of granules are uniformly mixed with magnesium stearate and micropowder silica gel, they are packed into capsules to make capsules.

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Abstract

The invention discloses a medicine composition for treating diabetes mellitus and complications thereof, and in particular relates to a medicine composition comprising arctigenin and rosiglitazone or pharmaceutically acceptable salts thereof, and application of the composition in preparation of a medicine for treating diabetes mellitus, diabetes mellitus complications and diseases relative to thediabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a pharmaceutical composition for treating diabetes, in particular to a pharmaceutical composition containing arctigenin and rosiglitazone or a pharmaceutically acceptable salt thereof. Background technique [0002] According to the statistics of the World Health Organization (WHO), there are currently about 194 million people with diabetes in the world, which will double by 2030. The number of diabetic patients in China has reached about 40 million, ranking second in the world after India. Type 2 diabetes accounts for about 90%-95% of the total number of diabetic patients in my country. Type 2 diabetes has become one of the major diseases threatening our national health. According to the latest epidemiological survey of diabetes in China by Diabetes Society of Chinese Medical Association, there are about 41 million people with diabetes among the urban population in my country,...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61K31/365A61P3/10
Inventor 刘树芹
Owner 江苏叠石桥家纺产业集团有限公司
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