Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel

A technology of artificial blood vessel and production method, which is applied in the direction of human tubular structure devices, blood vessels, non-woven fabrics, etc., can solve the problems of easy occlusion at the bend of the blood vessel, and the preparation method of spiral corrugations is not mentioned, and achieves the reduction of Thrombosis probability, improved hydrodynamic performance, easy peeling effect

Inactive Publication Date: 2013-07-10
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantages of this patent are: (1) It only elaborates on the spiral corrugation in theory, and does not mention the preparation method of the spiral corrugation
(2) The research object is artificial blood vessels with equal diameter and small diameter. However, according to the different shapes of diseased blood vessels, when the artificial blood vessels with equal diameter and small diameter are overlapped, the blood flow will be inconsistent due to the mismatch between the diameter of the artificial blood vessel and the host blood vessel. A vortex is formed at the interface, which in turn forms a thrombus
(3) The forming parameters of the spiral corrugation only consider the improvement of the blood flow state, and do not consider the problem of easy occlusion at the bend of the blood vessel during the bypass

Method used

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  • Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel
  • Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel
  • Electrostatic spinning production method of conical corrugated small-caliber artificial blood vessel

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Experimental program
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Effect test

Embodiment 1

[0023] Such as figure 1 As shown, it is a schematic diagram of the structure of the electrospinning collection device. The electrospinning collection device includes a conical collection roller 3, and the two ends of the conical collection roller 3 are fixed by the fixing device 1. A spiral corrugation processing device 2 is fixed. Described conical collection roller 3 is that the cone angle is 1 °, and the length is the aluminum matter truncated cone collection roller of 20cm. The spiral corrugation processing device 2 is a polyester strand (15D / 130F×3) wound on the outside of the conical collecting roller 3 in a spiral corrugation manner. The maximum angle is 5°, and the thread pitch is 2mm.

[0024] Dissolve polyester chips with an intrinsic viscosity of 0.8 in a mixed solution of trifluoroacetic acid and dichloromethane (volume ratio 4:1) to prepare a spinning solution with a mass fraction of 10%, and suck the spinning solution into the spinning tube , the inner diamete...

Embodiment 2

[0026] Such as figure 1 As shown, it is a schematic diagram of the structure of the electrospinning collection device. The electrospinning collection device includes a conical collection roller 3, and the two ends of the conical collection roller 3 are fixed by the fixing device 1. A spiral corrugation processing device 2 is fixed. Described conical collection roller 3 is that the cone angle is 3 °, and the length is the aluminum matter truncated cone collection roller of 20cm. The spiral corrugation processing device 2 is a polyester strand (15D / 130F×3) wound on the outside of the conical collecting roller 3 in a spiral corrugation manner. The maximum angle is 45°, and the thread pitch is 2mm.

[0027] Dissolve polylactic acid (PLLA) with a molecular weight of 100,000 in a mixed solution of chloroform and acetone (volume ratio 2:1) to prepare a spinning solution with a mass fraction of 5%, and suck the spinning solution into the spinning tube , the inner diameter of the ne...

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Abstract

The invention provides a conical corrugated small-caliber artificial blood vessel as well as an electrostatic spinning production method and equipment thereof. The conical corrugated small-caliber artificial blood vessel comprises a conical artificial blood vessel body, the inner wall of which is provided with spiral corrugation. The electrostatic spinning production method of the conical corrugated small-caliber artificial blood vessel comprises: dissolving a spinning polymer in a solvent to prepare a spinning solution, carrying out electrostatic spinning on the spinning solution, collectingby using an electrostatic spinning collection device, after the electrostatic spinning is completed, firstly opening a fixing device, then rotating and taking off a conical membrane from the small end of a conical collecting roller, and then drawing-off a spiral corrugation treatment device from a conical membrane cavity to obtain the conical corrugated small-caliber artificial blood vessel. The conical corrugated small-caliber artificial blood vessel provided by the invention can meet the bridging needs of the blood vessels with different diameters; and the spiral corrugation can not only promote the improvement of blood flow rate near the wall of the blood vessel, favor smooth washing of the inner wall and inhibit the thrombus formation, but also ensure that the bent positions of the blood vessels are not easy to block while bridging.

Description

technical field [0001] The invention relates to a conical corrugated small-diameter artificial blood vessel and its electrospinning production method and device, belonging to the field of medical artificial human organs. Background technique [0002] In vascular bypass and replacement surgery, small-caliber artificial blood vessels are prone to thrombosis, which leads to early failure of implantation. Studies have shown that the formation of thrombus is firstly the adhesion of platelets, and the subsequent forming process depends on the location of thrombus and local blood flow velocity. In order to solve this problem, the Chinese patent No. 200610054134.7, titled "An Artificial Blood Vessel", proposes to design a spiral groove on the inner wall of the blood vessel, thereby increasing the blood flow velocity on the wall, washing the inner wall of the artificial blood vessel, and reducing platelets and other substances in the blood vessel. Deposition on the wall surface, the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06D04H1/728D01D5/00
Inventor 李毓陵杜雪子丁辛王璐
Owner DONGHUA UNIV
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