18F-E[c(RGDyk)2], medicine box used for automatic production thereof, and preparation method and use of medicine box

A technology of 18F-E and 1.18F-E, applied in the direction of peptides, can solve the problems such as the limitation of popularization and application of imaging agents, and achieve the effects of good pharmacokinetic characteristics, good retention and convenient operation.
CN102268074BActive Publication Date: 2013-09-11JIANGSU INST OF NUCLEAR MEDICINE
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU INST OF NUCLEAR MEDICINE
Publication Date
2013-09-11

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Abstract

The invention discloses 18F-E[c(RGDyk)2], a medicine box used for automatic production thereof, and a preparation method and use of the medicine box, relates to a polyethylene terephthalate (PET) developer and a preparation method and use thereof and relates to the technical field of radiative medicines and nuclear medicines. The medicine box contains a raw material reagent A and a raw material reagent B. A bottle A contains E[c(RGDyk)2]-NO2; and A bottle B contains acetonitrile solution of crown ether K222 / K2CO3. The 18F-E[c(RGDyk)2] prepared by the medicine box has high absorbing performance and excellent retaining performance in model mouse tumor, and has a very high target / non target ratio, excellent pharmacokinetic characteristic and high biological performance, and can completely meet the requirements of PET developer of tumour integrin alphavbeta3 receptor.
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Description

technical field

[0001] The invention relates to a PET imaging agent and its preparation method and application, and belongs to the technical field of radiopharmaceuticals and nuclear medicine. Background technique

[0002] Positron emission tomography (PET) is a cutting-edge technology for biomedical research and clinical diagnosis in the 21st century. Gain insight into the activity of labeled drugs in normal or sick people. Compared with SPECT, PET has high resolution and can be quantitatively analyzed, which has obvious advantages.

[0003] 18 F has the characteristics of close to 100% positron efficiency, low positron energy (0.64 MeV) and relatively short physical half-life (t1 / 2=109.7 minutes), and is an ideal PET imaging nuclide. The polypeptide has the advantages of rapid tissue penetration, rapid clearance in the blood, low immunogenicity, etc., and is a suitable carrier for the preparation of PET imaging agents. Currently, peptides 18 The F-labeled process incl...

Claims

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