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A kind of quality detection method of camphor tree root and preparation containing camphor tree root

A quality testing method and a camphor tree root technology, applied in the field of traditional Chinese medicine, can solve the problems of insufficient research on the components of camphor tree root, inability to effectively control the quality of medicinal materials and preparations, and no establishment of a testing method for the medicinal materials of camphor tree root, etc. quality effect

Active Publication Date: 2011-12-28
JIANGXI HERBI SKY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the Chinese patent medicines Changyanning Tablets, Changyanning Syrup, Changyanning Oral Liquid, Changyanning Capsules, Changyanning Chewable Tablets, etc. that have been marketed in China all contain camphor root. There is no detection method for the medicinal materials of camphor tree root or only a simple identification in the drug standards of the People's Republic of China

Method used

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  • A kind of quality detection method of camphor tree root and preparation containing camphor tree root
  • A kind of quality detection method of camphor tree root and preparation containing camphor tree root
  • A kind of quality detection method of camphor tree root and preparation containing camphor tree root

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Determination of characteristic spectrum of medicinal materials of camphor tree root

[0022] Determination according to high performance liquid phase method (Appendix VI D of Chinese Pharmacopoeia 2010 edition):

[0023] Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel is used as filler; acetonitrile is used as mobile phase A, 0.1% phosphoric acid solution is used as mobile phase B, and gradient elution is carried out as specified in the table below; column temperature is 30°C; detection wavelength is 285nm . The number of theoretical plates is not less than 3000 based on dihydroquercetin;

[0024] time (minutes) Mobile phase A (%) Mobile phase B (%) 0～40 10～35 90～65 40～60 35～50 65～50 60～80 50 50

[0025] Preparation of reference solution Take an appropriate amount of camphoroside A reference substance, camphorside A aglycone reference substance, and dihydroquercetin refe...

experiment example 1

[0029] Experimental example 1 Study on the determination of characteristic spectrum of medicinal materials of camphor tree root

[0030] 1. Instruments and equipment, samples, reagents and reference substances

[0031] Equipment: Waters series high performance liquid chromatography, including: Waters 600 controller, PDA2996 diode array detector, Waters 717 plus automatic sampler, Empower chemical workstation. SHIMADZULC-2010AHT high performance liquid chromatography, UV variable wavelength detector, Lc-solution chromatography workstation. Sartorius BP211D electronic balance;

[0032] Column: Diamonsil C 18 (250×4.6mm, 5μm), waters Symmetry C 18 (250×4.6mm, 5μm) and Agilent ZORBAX SB-C 18 Diamonsil C 18 (250×4.6mm, 5μm);

[0033] Similarity calculation software: "Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System 2004 Version A" (issued by the National Pharmacopoeia Commission);

[0034] Reagents: Acetonitrile is chromatographically pure, water is...

Embodiment 2

[0097] Example 2 Determination of the content of dihydroquercetin in the root medicinal material of camphor tree

[0098] Determination according to high performance liquid phase method (Appendix VI D of Chinese Pharmacopoeia 2010 edition):

[0099] Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel is used as filler; acetonitrile-0.1% phosphoric acid (15:85) is used as mobile phase; detection wavelength is 288nm. The number of theoretical plates should not be less than 1500 based on the peak of dihydroquercetin;

[0100] Preparation of reference solution Accurately weigh an appropriate amount of dihydroquercetin reference substance, add methanol to make a solution containing 30 μg per 1ml, and obtain it;

[0101] Preparation of the test solutionTake about 2.5g of camphor tree root powder (passed through a No. 4 sieve), weigh it accurately, put it in a stoppered conical flask, add 50ml of methanol precisely, weigh it, soak it fo...

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Abstract

The invention discloses a quality detection method for a traditional Chinese medicinal material camphor tree root and a pharmaceutical preparation containing camphor tree root, camphor tree root extract or camphor tree root effective part. The method comprises one or more of the following detection methods: a. identification of a thin layer of camphor tree glycoside A; b. identification of liquidphase of dihydro-quercetinic acid; c. characteristic spectrum; and d. content determination of dihydro-quercetinic acid.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a method for detecting the quality of camphor tree roots and preparations containing camphor tree roots. Background technique [0002] The standard of medicinal materials of camphor tree root is recorded in the 1996 edition of "Standards of Traditional Chinese Medicinal Materials in Jiangxi Province". 廯. At present, the Chinese patent medicines Changyanning Tablets, Changyanning Syrup, Changyanning Oral Liquid, Changyanning Capsules, Changyanning Chewable Tablets, etc. that have been marketed in China all contain camphor root. There is no detection method for the medicinal materials of camphor tree root or only a simple identification in the drug standards of China. There is a lack of detection methods for active ingredients or characteristic components in the medicinal materials of camphor tree root, and the quality of medicinal materials and preparations cannot be e...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K36/74G01N30/90G01N30/36G01N30/02A61P1/00
Inventor 钟瑞建周国平吴安明艾样开吴孔松何杨虎张娜
Owner JIANGXI HERBI SKY CO LTD
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