Application of high-purity baicalin or baicalein to preparation of inhaled asthma relieving medicament

A technology of baicalin and baicalein, applied in the application field of baicalin or baicalein in the preparation of inhaled anti-asthmatic drugs, to achieve the effect of alleviating bronchospasm, controlling acute attacks, and low cost

Inactive Publication Date: 2012-01-04
LOGISTICS UNIV OF CAPF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no baicalin or baicalein made into inhalation preparations on the market, let alone high-purity, single-dose baicalin or baicalein made into inhalation preparations on the market

Method used

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  • Application of high-purity baicalin or baicalein to preparation of inhaled asthma relieving medicament
  • Application of high-purity baicalin or baicalein to preparation of inhaled asthma relieving medicament
  • Application of high-purity baicalin or baicalein to preparation of inhaled asthma relieving medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Inhaled asthma powder:

[0032] prescription

[0033]

[0034] Preparation method: Micronize baicalin, select lactose and leucine with a particle size of 0.5-5 μm as carriers, add an appropriate amount of 50% (v / v) ethanol aqueous solution to granulate, place in a rotary vibrating sieve, shake for 50 minutes, and dry That is, the particle size is 0.5-5 μm. After intermediate analysis and content determination, it is filled into capsules, and each capsule contains 30 mg of the main drug, and is used by means of a capsule-type propeller-type dry powder inhaler.

Embodiment 2

[0036] Inhaled asthma powder:

[0037] prescription

[0038] Baicalin 15g (the purity of baicalin is 91%)

[0039] Lactose 60g

[0040] Poloxamer 0.03g

[0041] Preparation method: After uniformly mixing the components in the above prescription, add an appropriate amount of 95% (v / v) ethanol aqueous solution to form a solution, micronize it by spray drying to make the average particle size reach 1-5 μm, and sieve through a 100-mesh sieve. Capsules. After intermediate analysis and content determination, it is filled into capsules and used by means of capsule-type propeller dry powder inhalers.

Embodiment 3

[0043] Inhaled asthma powder:

[0044] prescription:

[0045] Baicalin 0.1g (the purity of baicalin is 98%)

[0046] Mannitol 98g

[0047] Preparation method: baicalin is spray-dried, and then nano-powder is prepared by high-pressure homogeneous method, with a particle size of 100-900nm; mannitol is made into a micropowder of about 150 μm, and baicalin nanopowder and mannitol are made into a micropowder of about 150 μm and mixed evenly. 100 mesh sieve, packed in capsules. After intermediate analysis and content determination, it is filled into capsules and used by means of capsule-type propeller dry powder inhalers.

[0048] Mannitol in this example can also be replaced by polyethylene glycol 6000 or gum arabic to prepare inhalation powder.

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PUM

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Abstract

The invention discloses application of high-purity baicalin or baicalein to the preparation of inhaled asthma relieving medicaments. The inhaled asthma relieving medicaments comprise the formulations of inhaled solution or inhaled powder sprays, wherein the inhaled solution is prepared from the baicalin or the baicalein and pharmaceutical adjuvants A, and the pharmaceutical adjuvants may be one or more of solvents, latent solvents, surfactants or antioxidants; the inhaled powder sprays are prepared from the baicalin or the baicalein or pharmaceutical adjuvants B, and the pharmaceutical adjuvants B may be one or more of the solvents, the antioxidants or carriers; and the purity of the baicalin or the baicalein is more than 90 percent. Experiments proves that the inhaled asthma relieving medicaments prepared from the high-purity baicalin or baicalein can control the acute paroxysm of asthma effectively, relieve bronchospasm and reduce the resistance of air passages, is high in medicinal effect, small in side effect, nontoxic and low in cost.

Description

technical field [0001] The present invention relates to the application of baicalin or baicalein, in particular to the application of baicalin or baicalein in the preparation of inhaled anti-asthma medicine. Background technique [0002] Asthma is involved in a variety of cells including airway inflammatory cells and structural cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, smooth muscle cells, airway epithelial cells, etc.) and cellular components Chronic inflammatory disease of the airways. The latest research shows that the incidence of asthma is gradually increasing, but the asthma-related hospitalization rate and mortality rate have been significantly reduced, mainly due to the in-depth study of the pathogenesis of asthma, asthma treatment has achieved both drugs and non-drugs. Great progress and breakthrough. [0003] US researchers have discovered a "taste receptor" in the lungs of mice that can effectively relieve asthma symptoms. This discove...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61K9/72A61P11/06A61P11/00
Inventor 高颖陈虹陈若芸李覃曹波白淑芳
Owner LOGISTICS UNIV OF CAPF
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