Application of brassica rapa organic acid to preparation of medicaments for reducing blood sugar

An organic acid and hypoglycemic technology, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve the effects of low production costs, simple methods, and high organic acid content

Active Publication Date: 2012-01-04
西藏自治区高原生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the published methods for the development and utilization of coriander root, there is no report on the hypoglycemic effect of coriander root organic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Using method A, the root raw material of coriander root was soaked in 5 times the volume of 90% ethanol for 8 hours, then refluxed at 50°C for 2 hours, and the extraction was repeated 4 times. Combine the extracts and filter. Concentrate the filtrate under reduced pressure at 50°C into a non-alcoholic extract. Add a small amount of water to dissolve the concentrated extract (volume ratio 1:1.5). Use AB-8 macroporous adsorption resin to absorb the solution, first wash away the more polar impurities with 3 times the column volume of water, and then elute with 5 times the column volume of 30% ethanol at a flow rate of 0.5ml / min , collect the eluent, concentrate and dry, the organic acid yield of Coriander root is 0.51%, and its purity is 43%.

Embodiment 2

[0046] Using method A, the root raw material of coriander root was soaked in 10 times the volume of 50% ethanol for 10 hours, then refluxed at 60°C for 0.5 hours, and the extraction was repeated 4 times. Combine the extracts and filter. Concentrate the filtrate under reduced pressure at 60°C into a non-alcoholic extract. Add a small amount of water to dissolve the concentrated extract (volume ratio 1:1.5). Utilize HPD100 type macroporous adsorption resin to absorb the solution, first wash away the more polar impurities with 2 times column volume of water, then elute with 3 times column volume of 95% ethanol at a flow rate of 0.5ml / min, collect The eluate was concentrated and dried, and the yield of coriander root organic acid was 1.61%, and its purity was 71%.

Embodiment 3

[0048]Using method A, the raw material of coriander root was soaked in 15 times the volume of 50% ethanol, soaked for 14 hours, extracted under reflux at 70°C for 2 hours, and the extraction was repeated once. Combine the extracts and filter. Concentrate the filtrate under reduced pressure at 70°C into an alcohol-free extract. Add a small amount of water to dissolve the concentrated extract (volume ratio 1:2). Utilize the HPD400 type macroporous adsorption resin to absorb the solution, first wash away the more polar impurities with water of 1 times the column volume, and then elute with 50% ethanol of 5 times the column volume at a flow rate of 2ml / min, collect and wash Deliquoring, concentrating and drying, the yield of coriander root organic acid is 0.79%, and its purity is 60%.

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PUM

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Abstract

The invention relates to application of brassica rapa organic acid extracted from brassica rapa plants to the preparation of medicaments for reducing blood sugar. The brassica rapa organic acid has an obvious effect in aspects of reducing blood sugar, adopts readily available raw materials, and is low in production cost, high in content, stable in quality and easy to control, and a method is simple.

Description

technical field [0001] The invention relates to the application of the organic acid extracted from the root of the root of the root of the root of the root of the root to prepare the hypoglycemic drug, and belongs to the field of medicinal natural products. Background technique [0002] A large number of epidemiological studies have shown that abnormally elevated blood sugar is a risk factor for diabetes. Diabetes is a common endocrine and metabolic disease and the third major disease that endangers human health after cardiovascular disease and cancer. Because diabetes has the characteristics of high prevalence rate, disability rate and high complication rate, it has become one of the diseases that the medical field has paid much attention to and paid more attention to. [0003] Most of the current hypoglycemic drugs are Western medicines or large compound prescriptions of traditional Chinese medicines. Western medicines (including injections and oral hypoglycemic drugs) hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P3/10
Inventor 蒋思萍高平
Owner 西藏自治区高原生物研究所
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