Method for extracting theophylline sodium salt or theophylline by styrene type macroporous resin

Abstract

The invention discloses a method for extracting theophylline sodium salt or theophylline from a theophylline sodium salt or theophylline mother solution by a styrene type macroporous resin adsorption method, which comprises the following steps: (1) regulating the pH value of the theophylline sodium salt or theophylline mother solution; (2) filtering the mother solution and removing suspended impurities in the mother solution; (3) adsorbing the mother solution by adsorption resin; (4) desorbing the adsorption resin after adsorption saturation by a desorbing agent to obtain a desorption solution; (5) regulating the pH value of the desorption solution, standing and crystallizing theophylline sodium salt or theophylline; (6) centrifugally filtering; and (7) drying to obtain solid theophylline sodium salt. The method provided by the invention has the advantages that the theophylline sodium salt or theophylline crude product has better quality, the operation safety is better, the extraction efficiency is higher, the extraction cost is low, and the method is more suitable for mass production and facilitates realizing automatic operation. With the method disclosed by the invention, the extraction cost of the theophylline sodium salt and theophylline can be reduced, the extraction yield of the theophylline sodium salt and theophylline is increased, and the competitiveness of enterprises is enhanced.

Description

technical field [0001] The present invention relates to a method for extracting theophylline sodium salt or theophylline, in particular to a method for extracting theophylline sodium salt or theophylline from theophylline sodium salt or theophylline mother liquor by using a styrene-type macroporous resin adsorption method, which belongs to The method of separating organic matter from organic synthesis chemical mother liquor is also a kind of chemical environmental protection technology. Background technique [0002] Theophylline sodium salt is an organic substance slightly soluble in water. During the production process of synthesizing theophylline or theophylline sodium salt, a certain amount of chemical mother liquor will be produced. The mother liquor contains a small amount of theophylline or theophylline sodium salt. For a long time , bringing great burden and difficulty to wastewater treatment. [0003] In recent years, domestic and foreign research institutes and man...

AI Technical Summary

Problems solved by technology

[0009] This method requires the use of organic solvents such as octanol as extractants. These extractants are volatile and have certain toxicity. At the same time, organic solvents such as octanol have certain solubility in the water phase, and a part of octanol and theophylline remain in the raffinate. , resulting in loss of target isolate

Therefore, in the process of operation, it will not only cause certain air and water pollution, loss of organic solvents such as octanol, but also cause loss of theophylline, and the recovery cost remains high.