Polymethyl polyglycol methacrylate containing paracetamol structure as well as preparation method and use method thereof

A technology of polymethylpolyethylene glycol acrylate and methylpolyethylene glycol acrylate, which is applied in the field of polymethylpolyethylene glycol acrylate containing paracetamol structure and its preparation, and can solve the problems of cumbersome preparation methods and the like , to achieve good analgesic effect

Inactive Publication Date: 2012-02-08
TIANJIN POLYTECHNIC UNIV
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Problems solved by technology

However, its preparation method is cumbersome

Method used

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  • Polymethyl polyglycol methacrylate containing paracetamol structure as well as preparation method and use method thereof
  • Polymethyl polyglycol methacrylate containing paracetamol structure as well as preparation method and use method thereof
  • Polymethyl polyglycol methacrylate containing paracetamol structure as well as preparation method and use method thereof

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Embodiment Construction

[0035] Below in conjunction with accompanying drawing and specific embodiment the present invention is described in further detail:

[0036] The 4-nitrate-p-acrylamide phenyl butyrate (NAPB) and its analogues in the present invention are 4-nitrate-p-acrylamide phenyl butyrate and its various substitutions on the acryloyl structure The derivatives of the base; the methyl polyethylene glycol acrylate and its derivatives are methyl polyethylene glycol acrylate and its derivatives with various substituents added to the acryloyl structure; the methyl The molecular weight of methyl polyethylene glycol in polyethylene glycol acrylate and its derivatives is 1000-5000; the described methyl acrylate and its analogs are various derivatives containing acrylate structure, containing vinyl sulfonate Various derivatives of acid sodium (vinyl sulfonamide) structure and 2-methacryloyloxyethyl phosphorylcholine; the free radical initiator is Cl 2 、Br 2 , Organic peroxides (such as cyclohexanone...

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Abstract

The invention discloses a polymethyl polyglycol methacrylate containing a paracetamol structure as well as a preparation method and a use method thereof. The preparation method comprises the following steps of: mixing 4-nitrate ester-pacrylamide phenyl butyrate compounds, methyl acrylate compounds and methylpropenoic polyglycol acid ester compounds; polymerizing free groups under the protection of nitrogen gas; reacting at the temperature of 20-90DEG C for 1-20 hours; repeatedly precipitating and dissolving generated polymerisate by petroleum ether and tetrahydrofuran; and finally, vacuum drying. The obtained polymer has a certain analgesic function and a better anticoagulation effect.

Description

technical field [0001] The present invention relates to polymethylpolyethylene glycol acrylate and its preparation method and application method, in particular to polymethylpolyethylene glycol acrylate containing paracetamol structure and its preparation for anticoagulation on the surface of polymers method and method of use. Background technique [0002] In recent years, the research on the blood compatibility of the surface of biomedical materials used in contact with blood has attracted people's attention and has become a research hotspot. Blood-compatibility means that the material does not cause denaturation of plasma proteins, does not destroy the active ingredients of blood, does not cause blood coagulation and thrombus formation after contact with blood. As early as the 1960s, it was discovered that when biomaterials are implanted into the body and come into contact with blood, protein molecules will be adsorbed on the surface of the material, which will induce bloo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F290/06C08F222/38C08F220/14A61L33/06
Inventor 王翔曹雪陈雪赵俊龙李秀丽王竹林
Owner TIANJIN POLYTECHNIC UNIV
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