Biodegradable scaffold

A biodegradable material technology, applied in the field of medical devices, can solve problems such as stent narrowing, stent collapse, and displacement, and achieve the effects of controllable heating temperature, concentrated heating points, and reduced retraction rate

Active Publication Date: 2012-03-14
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the stress-strain curve, the elastic deformation range of the polymer is much larger than that of the metal. For the stent, under the same balloon expansion conditions, the metal stent mainly deforms plastically, wh

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0038] Example one:

[0039] In the embodiment of the present application, a number of magnetic particles 3 are distributed in the stent body 1.

[0040] Such as figure 2 As shown, this is a cross-sectional view of the stent rod provided in the first embodiment of the application. In the figure, several magnetic particles 3 are uniformly distributed in the stent body 1. The main material is a material that can generate heat under the action of an alternating magnetic field, including but Not limited to γ-Fe 2 O 3 , Fe 3 O 4 , Ni, Co, Fe, FeCo, NiFe, CoFeO, NiFeO, MnFeO one or more. In addition, in the embodiments of the present application, the diameter of the magnetic particles 3 is in the nanometer range, preferably 10-100 nm, and the mass ratio of the magnetic particles 3 to the degradable material in the stent body 1 is 1:10-1:100.

[0041] In order to improve the biocompatibility and dispersibility of the magnetic particles 3, in the embodiments of the present application, it ...

Example Embodiment

[0042] Embodiment two:

[0043] Such as image 3 As shown, a cross-sectional view of a stent rod provided by an embodiment of this application. On the basis of Embodiment 1, the biodegradable stent further includes: an inner coating of biodegradable material coated on the inner circumference of the stent body 1 4.

[0044] The degradable material of the inner coating 4 is the same as the material of the stent body 1 in Example 1, including but not limited to polylactic acid, polyglycolic acid, copolymers of polylactic acid and polyglycolic acid, polycaprolactone, and polydioxide. One or more of hexacyclic ketone, polyanhydride, and tyrosine polycarbonate.

[0045] In the embodiments of this application, preferably, such as Figure 4 As shown, several magnetic particles 3 are also distributed in the inner coating 4, and several magnetic particles 3 are uniformly distributed in the inner coating 4.

[0046] In other embodiments of this application, such as Figure 5 As shown, the biode...

Example Embodiment

[0047] Embodiment three:

[0048] Image 6 This is a cross-sectional view of a support rod provided in the third embodiment of this application.

[0049] Such as Image 6 As shown, the biodegradable stent includes: a stent body 1 made of a degradable material and an inner coating 4 of biodegradable material coated on the inner circumference of the stent body, and a plurality of magnetic materials are distributed in the inner coating 4 Particle 3.

[0050] In the embodiments of the present application, the degradable materials in the stent body 1 and the inner coating 4 are the same as those in the previous embodiments, and the magnetic particles 3 are also the same as in the previous embodiments.

[0051] In other embodiments of this application, such as Figure 7 As shown, the biodegradable stent further includes: a biodegradable material outer coating 5 coated on the outer periphery of the stent body 1, and drugs can be added to the outer coating 5. After the stent is implanted in t...

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Abstract

The invention discloses a biodegradable scaffold, which comprises a scaffold main body prepared by a biodegradable material. A lot of magnetic particles are distributed in the scaffold main body. According to the biodegradable scaffold, the magnetic nano-particles are added to the biodegradable polymer of the biodegradable scaffold; after expansion, the magnetic nano-particles inside the biodegradable scaffold are heated with the external alternating magnetic field to generate the heat energy, such that the local heating for the scaffold is achieved, the scaffold is subjected to thermoplastic deformation; the scaffold can be fixed and formed after the scaffold is cooled. The heating way by adopting the external alternating magnetic field has advantages of heating point centralizing, controllable heating temperature and less damage to the surrounding environment organizations, such that the retraction rate of the biodegradable scaffold of the present invention after the expansion can be effectively reduced, the problem of the restenosis generating inside the scaffold due to the scaffold collapsing and the scaffold shifting can be avoided, wherein the high retraction rate of the biodegradable scaffold in the prior art can cause the scaffold collapsing and the scaffold shifting.

Description

technical field [0001] The present application relates to the technical field of medical devices, in particular to a biodegradable stent. Background technique [0002] With the gradual deepening of research on biodegradable materials, at present, its performance in various aspects is more suitable for the preparation of new biodegradable scaffolds, and there are quite a few research institutions currently conducting the development and experiments of biodegradable scaffolds. Some clinical data show that: biodegradable stents show good clinical effects, and are gradually approaching metal stents in terms of physical properties and delivery performance. It gradually degrades after treatment, so it has great potential and development prospects. [0003] Restricted by the shape and diameter of the coronary arteries, the stents used to treat coronary stenosis are generally balloon-expandable, that is, the stent is preloaded onto the balloon of the delivery system, and the stent ...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/10A61L31/08A61L31/16A61L31/14A61F2/90
Inventor 黄楚波石秀凤罗七一王一涵孟娟
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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