Macrolide compound ultralow volume formulation

Abstract

The invention relates to a macrolide compound ultralow volume formulation. An active component I and an active component II are used as active components with the addition of a solvent and an auxiliary agent to prepare the ultralow volume liquid formulation, Wherein the active component I contains one or more ingredients selected from the group consisting of a macrolide compound avermectin, emamectin benzoate and ivermectin; the active component II contains one or more ingredients selected from the group consisting of chlorantraniliprole, flubendiamide, metaflumizone, ethiprole, indoxacarb, spinosad, spinetoram, guinalphos and basudin; the content of the active component I is 0.1-5% and the content of the active component II is 0.1-20%; and the cotoxicity coefficient calculated according to Sunyunpei method. The invention is suitable for ultralow volume spraying, low volume spraying and electrostatic spraying, and has advantages of high work efficiency, fast effectiveness, long persistent period, water saving, cooperative synergism and the like.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and in particular relates to an ultra-low-capacity liquid formulation of a macrolide compound. Background technique [0002] Macrolide antibiotics are a class of antibacterial drugs with a common chemical structure of 12-16 carbon lactone rings. They are secondary metabolites of actinomycetes and have high activity against harmful insects. Macrolides include abamectin, emamectin benzoate, ivermectin and other substances. Abamectin is a class of 16-membered macrolide compound with insecticidal, acaricidal and nematicidal activities, which is produced by fermentation of Streptomyces avermitilis in Streptomyces. Natural avermectin contains 8 components, mainly 4 kinds, namely A1a, A2a, B1a and B2a, the total content of which is ≥80%; the corresponding 4 homologues with smaller proportions are A1b, A2b, B1b and B2b , and its total content ≤ 20%. It has the characteristics of novel structure and...

AI Technical Summary

Problems solved by technology

[0018] 2. Conventional spraying method needs a lot of water to control diseases and insect pests, usually the water consumption is 450~900L / hm 2 , and in many areas far away from water sources and arid and water-scarce areas, conventional spraying methods are difficult to implement or cannot achieve the desired control effect

[0019] 3. The medicines used in the conventional spraying method have a short duration of action. Since the dosage forms of the medicines used in the conventional spraying method are usually emulsifiable concentrates, water preparations, wettable powders, suspension concentrates, and water-emulsions, there are certain defects in use:

[0020] (1) Due to the addition of a large amount of water for dilution, the concentration of the medicinal solution is very low, and the surface tension is often high. The adhesion, wettability, and permeability on the surface of the crop or target with a waxy layer are poor, and it is difficult to effectively enter In vivo of crops and targets, resulting in poor control effect;

[0021] (2) In the natural environment of light, high temperature, and dryness, the water in the liquid medicine is easy to evaporate, causing the medicine to only remain on the surface of the crops, and it is easy to fall off from the crops after photolysis and drying to become ineffective;

[0022] (3) The droplet size of conventional spraying is relatively large, reaching 200-600 μm, which leads to the easy loss of the liquid medicine sprayed on the surface of crops or targets

[0023] (4) For a long time, the single and frequent use of pesticide varieties has increased the resistance of biological targets to the pesticide itself, which is not conducive to the prevention and control of harmful organisms

Images