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Chitosan polymer and preparation method thereof

A technology of chitosan polymer and chitosan powder, applied in medical science, prosthesis, etc., can solve the problem that various cells cannot grow well, cannot promote bone regeneration well, and cannot grow as a carrier activity The carrier of the factor and other issues, to achieve the effect of non-toxic side effects, convenient source, and good stability

Inactive Publication Date: 2012-04-04
赵文 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the existing chitosan can only be used as a scaffold material, but not as a carrier for carrying active growth factors, and various cells cannot grow well on the surface and inside of it, so it cannot promote bone regeneration well.

Method used

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  • Chitosan polymer and preparation method thereof
  • Chitosan polymer and preparation method thereof
  • Chitosan polymer and preparation method thereof

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Embodiment Construction

[0016] The present invention will be further described below in conjunction with specific embodiments.

[0017] The raw materials used in the method of the present invention are: natural chitosan powder, gelatin powder, genipin solution, glycerol-2-phosphate disodium powder, and in the preparation process, specifically include the preparation stage of raw materials before synthesis and Synthesis stages of chitosan polymer.

[0018] In the preparation stage of raw materials before synthesis, (1) firstly use acetic acid solution with a mass concentration of 0.4% to dissolve natural chitosan powder into a chitosan solution with a mass concentration of (1-2)%, and then heat it to 35° C, after stirring for 2-3 days, filter the solution and sterilize it at 110°C for use; (2) Then, dissolve the gelatin powder into a solution with a mass concentration of (1.5-2)% in pure water, and dissolve it at 110°C (3) dilute the genipin solution into a genipin-alcohol solution with a mass concen...

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Abstract

The invention relates to a medical material for surgery, in particular to a chitosan polymer capable of being used as a medical bioengineering scaffold and a carrier carrying active growth factors and a preparation method thereof. In the preparation method, the raw materials comprise natural chitosan powder, gelatin powder, genipin solution and glycerol-2-disodium phosphate powder; the preparation method comprises a preparation stage of the raw materials before synthesis and a synthesis stage; and in the synthesis stage of the chitosan polymer, the natural chitosan is subjected to chemical cross-linking and ion cross-linking with the genipin and the glycerol-2-disodium phosphate respectively, and the gelatinous chitosan polymer is obtained. The method is simple in operation, the adopted materials are natural and nontoxic and are conveniently obtained, and the chitosan polymer produced by using the method has good stability and can be used as the medical bioengineering scaffold and thecarrier carrying the active growth factors.

Description

technical field [0001] The invention relates to a medical material for surgery, in particular to a chitosan polymer which can be used as a medical bioengineering support and a carrier for carrying active growth factors and its preparation method. Background technique [0002] The application of chitosan-based materials in bone tissue engineering is receiving more and more attention. Chitosan is an ideal polymer biomaterial, which has the characteristics of small body reaction, good biodegradability, non-toxicity, wide range of sources, cheap price, natural antibacterial property and arbitrary plasticity such as porous structure, making it It can be suitable for the inner growth of cells and bone conduction, showing great application value in bone tissue engineering. However, most of the existing chitosan can only be used as a scaffold material, but not as a carrier for carrying active growth factors, and various cells cannot grow well on the surface and inside of it, so it ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08L89/00A61L27/20A61L27/52
Inventor 赵文
Owner 赵文
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