Levalbuterol sulfate pulsatile capsule and preparation method thereof
A technology of salbutamol sulfate and capsules, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc.
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Embodiment 1
[0032] (1) Preparation of styrenesulfonic acid-methacrylic acid copolymer
[0033] All monomers were distilled under reduced pressure to remove the polymerization inhibitor before the reaction. First, 17mL (0.2mol) of MAA and 5.75mL (0.05mol) of styrene were added to a three-necked flask equipped with mechanical stirring and a reflux condenser, and then 133mg of 0.7wt% crosslinking agent divinylbenzene and 0.5wt% supernatant were added. Benzoyl oxide 95 mg was used as an initiator. Then 20 mL of 10% PVA aqueous solution (w / v) was slowly added dropwise to the mixture, and N 2 About 30 minutes or so to remove the O dissolved in the solution that can prevent the polymerization reaction 2. In the polymerization reaction, the temperature was raised slowly for 30 minutes to 70°C for 2 hours under vigorous stirring. Slowly raise the temperature for 1 hour to above 90°C and react for 4 hours. Polymer microspheres were filtered and washed repeatedly with methanol and hot water at ...
Embodiment 2
[0039] (1) Preparation of styrenesulfonic acid-methacrylic acid copolymer
[0040] All monomers were distilled under reduced pressure to remove the polymerization inhibitor before the reaction. First, add 4.25mL (0.05mol) of MAA and 23mL (0.2mol) of styrene into a three-necked bottle equipped with mechanical stirring and reflux condenser, then add 0.7wt% crosslinking agent divinylbenzene 133mg and 0.5wt% Benzoyl peroxide 95 mg was used as an initiator. Then 20 mL of 10% PVA aqueous solution (w / v) was slowly added dropwise to the mixture, and N 2 About 30 minutes or so to remove the O dissolved in the solution that can prevent the polymerization reaction 2 . In the polymerization reaction, the temperature was raised slowly for 30 minutes to 70°C for 2 hours under vigorous stirring. Slowly raise the temperature for 1 hour to above 90°C and react for 4 hours. Polymer microspheres were filtered and washed repeatedly with methanol and hot water at 70°C to remove unreacted co...
Embodiment 3
[0046] (1) Preparation of styrenesulfonic acid-methacrylic acid copolymer
[0047] All monomers were distilled under reduced pressure to remove the polymerization inhibitor before the reaction. First, MAA8.5mL (0.1mol) and styrene 11.5mL (0.1mol) were added to a three-necked bottle equipped with mechanical stirring and reflux condenser, and then 0.7wt% crosslinking agent divinylbenzene 133mg and 0.5wt % Benzoyl peroxide 95mg as initiator. Then 20 mL of 10% PVA aqueous solution (w / v) was slowly added dropwise to the mixture, and N 2 About 30 minutes or so to remove the O dissolved in the solution that can prevent the polymerization reaction 2 . In the polymerization reaction, the temperature was raised slowly for 30 minutes to 70°C for 2 hours under vigorous stirring. Slowly raise the temperature for 1 hour to above 90°C and react for 4 hours. Polymer microspheres were filtered and washed repeatedly with methanol and hot water at 70°C to remove unreacted components. Let d...
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