Sustained releasing preparation of vilamin C and its preparing method

Abstract

A slow-releasing VC in the form of micropills is composed of pill and coated layer. Said pill is prepared from core, VC, antioxidizing agent, synergistic, adhesive and other auxiliary. Said coated layer is prepared from slow-releasing material, plasticizer, pore forming agent and defoaming agent.

Description

technical field [0001] The present invention relates to a dosage form of vitamin C, in particular to a vitamin C slow-release preparation and a preparation method thereof Background technique [0002] Vitamin C, also known as ascorbic acid, is one of the 26 basic medicines for human beings jointly identified by the United Nations Industrial Development Organization and the World Health Organization. Vitamin C is an unstable substance, which is easily oxidized and decomposed in the environment of light, heat, water, oxygen, alkali, etc. and becomes invalid. Humans cannot synthesize vitamin C by themselves, and can only obtain this substance necessary for maintaining the body from the diet. At present, there are many vitamin C preparations on the market, but vitamin C is quickly absorbed by the small intestine after oral administration, and the stable concentration in the body is 10-15mg / l. The original form is excreted from the body. When taking large d...

AI Technical Summary

Problems solved by technology

At present, there are many vitamin C preparations on the market, but vitamin C is quickly absorbed by the small intestine after oral administration, and the stable concentration in the body is 10-15mg / l. The original form is excreted from the body. When taking large doses of vitamin C clinically, patients often need to take it frequently. The patient's compliance is poor, and there are often missed doses.

How to develop a stable vitamin C preparation with a long sustained-release effect has been pursued by people. In many countries such as the United States, France, Britain, and Germany, many companies are selling a vitamin C packaged in ethyl cellulose. Vitamin C granules behind clothing, which can solve the problem of oxidative discoloration of vitamin C to a large extent, but cannot provide a good sustained release effect