Sustained releasing preparation of vilamin C and its preparing method

A technology of sustained-release preparations and vitamins, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as poor patient compliance, missed doses, and inability to provide good sustained-release effects, etc. question

Inactive Publication Date: 2005-02-23
范敏华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many vitamin C preparations on the market, but vitamin C is quickly absorbed by the small intestine after oral administration, and the stable concentration in the body is 10-15mg / l. The original form is excreted from the body. When taking large doses of vitamin C clinically, patients often need to take it frequently. The patient's compliance is poor, and there are often missed doses.
How to develop a stable vitamin C preparation with a long sustained-release effect has been pursued by people. In many countries such as the United States, France, Britain, and Germany, many companies are selling a vitamin C packaged in ethyl cellulose. Vitamin C granules behind clothing, which can solve the problem of oxidative discoloration of vitamin C to a large extent, but cannot provide a good sustained release effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The present invention is further described by the following examples, but the present invention is not limited by the examples.

[0009] 1. Embodiment:

[0010] formula:

[0011] Vitamin C 1000.0g

[0012] Sucrose Type Medicinal Pellets 172.0g

[0013] Povidone 4.0g

[0014] Citric acid 40.0g

[0015] Hypromellose (100000cp) 1g

[0016] Pharmacoat 606 10g

[0017] Disodium edetate 0.34 g

[0018] Sodium Carboxymethyl Cellulose 16.0g

[0019] Ethylcellulose 103.2 g

[0020] Diethyl phthalate 12.3 g

[0021] Process steps:

[0022] 1. Take povidone, hypromellose (100000cp), citric acid, disodium edetate, and sodium carboxymethylcellulose and dissolve them in an appropriate amount of water;

[0023] 2. Add 80% of the prescribed amount of vitamin C to "1", and stir while adding water until all the vitamin C is dissolved;

[0024] 3. Take the prescribed quantity of blank cores, and load the solution "2" containing vitamin C...

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PUM

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Abstract

A slow-releasing VC in the form of micropills is composed of pill and coated layer. Said pill is prepared from core, VC, antioxidizing agent, synergistic, adhesive and other auxiliary. Said coated layer is prepared from slow-releasing material, plasticizer, pore forming agent and defoaming agent.

Description

technical field [0001] The present invention relates to a dosage form of vitamin C, in particular to a vitamin C slow-release preparation and a preparation method thereof Background technique [0002] Vitamin C, also known as ascorbic acid, is one of the 26 basic medicines for human beings jointly identified by the United Nations Industrial Development Organization and the World Health Organization. Vitamin C is an unstable substance, which is easily oxidized and decomposed in the environment of light, heat, water, oxygen, alkali, etc. and becomes invalid. Humans cannot synthesize vitamin C by themselves, and can only obtain this substance necessary for maintaining the body from the diet. At present, there are many vitamin C preparations on the market, but vitamin C is quickly absorbed by the small intestine after oral administration, and the stable concentration in the body is 10-15mg / l. The original form is excreted from the body. When taking large d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/375A61K47/20A61P3/02A61P3/06
Inventor 范敏华
Owner 范敏华
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