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Cefdinir dispersible tablet and preparation method thereof

A technology for cefdinir and dispersible tablets, applied in the field of cefdinir dispersible tablets and their preparation, can solve the problems of fluctuating clinical efficacy of tablets, slow disintegration and dissolution, low bioavailability and the like, and achieve continuous blood drug concentration. Good properties, increased drug distribution area, and low drug dosage

Inactive Publication Date: 2009-01-28
TIANJIN CENT PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The clinical curative effect of the existing tablets of cefdinir fluctuates, due to poor solubility, slow disintegration and dissolution, unable to take effect in time, low bioavailability, and poor therapeutic effect

Method used

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  • Cefdinir dispersible tablet and preparation method thereof
  • Cefdinir dispersible tablet and preparation method thereof
  • Cefdinir dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Specification: 50mg

[0044] Product name Quantity per piece

[0045] Cefdinir 50.00mg

[0046] Crospovidone (PVPP) 31.25mg

[0047] Microcrystalline Cellulose (MCC) 62.50mg

[0048] Aspartame 0.25mg

[0049] Micronized silica gel 3.00mg

[0050] Magnesium Stearate 1.50mg

[0051] Total: 148.50mg

Embodiment 2

[0053] Specification: 0.1g

[0054] Product name Quantity per piece

[0055] Cefdinir 100.00mg

[0056] Crospovidone (PVPP) 62.50mg

[0057] Microcrystalline Cellulose (MCC) 125.00mg

[0058] Aspartame 0.50mg

[0059] Micronized silica gel 6.00mg

[0060] Magnesium Stearate 3.00mg

[0061] Total: 297mg

Embodiment 3

[0063] Specification: 50mg

[0064] Product name Quantity per piece

[0065] Cefdinir 50.00mg

[0066] Crospovidone (PVPP) 31.25mg

[0067] Microcrystalline Cellulose (MCC) 62.50mg

[0068] Aspartame 0.25mg

[0069] Micronized silica gel 3.00mg

[0070] Magnesium Stearate 1.50mg

[0071] Total: 148.50mg

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PUM

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Abstract

The invention provides a cefdinir dispersible tablet and a preparation method thereof, and the cefdinir dispersible tablet contains cefdinir with effective dose and pharmaceutic adjuvant which includes disintegrant and disintegrant-promoting aerosol; in every 100 parts of cefdinir, the dosage of the disintegrant is 2-60 parts, and the dosage of the disintegrant-promoting aerosol is 0.1-45 parts; after being taken orally, the cefdinir dispersible tablet of the invention can quickly disintegrate, and the cefdinir which is the active ingredient of the dispersible tablet has the accumulating dissolution rate of over 102.0% within 15 minutes. Compared with other medicines, the accumulating dissolution rate of cefdinir capsule is 98.3%. The cefdinir dispersible tablet are evenly dispersed into fine particles, so as to have remarkable disintegration and leachability capacity compared with the compressed tablets, realize the rapid absorption of medicine, the function of rapid onset, and improve the bioavailability of human body.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to an improved pharmaceutical dosage form of cefdinir, more specifically a cefdinir dispersible tablet and a preparation method thereof. Background technique [0002] Cefdinir (Cefdinir) is an oral third-generation cephalosporin with a broad antibacterial spectrum. Its antibacterial effect on Staphylococcus and Streptococcus is similar to that of cefpodoxime axetil, and its antibacterial activity on Enterobacteriaceae is lower than that of Cefixime 2 -4 times. Enterococcus, Pseudomonas aeruginosa and other Pseudomonas, Acinetobacter, etc. are mostly resistant to this product. Cefdinir is mainly used to treat mild to moderate infections in adults and children caused by sensitive bacteria, including respiratory infections: pharyngitis, tonsillitis, acute bronchitis, pneumonia, acute sinusitis and other mild to moderate skin and soft tissue infections, Acute otitis ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61P31/04
Inventor 杨福桢庞东颖
Owner TIANJIN CENT PHARM CO LTD
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