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Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof

A technology for gastrointestinal diseases and compositions, which is applied in the field of traditional Chinese medicine compositions for treating gastrointestinal diseases and its preparation, and can solve problems such as mercury hazards, fetal and infant health hazards, and endocrine system hazards

Active Publication Date: 2012-05-02
津药达仁堂集团股份有限公司乐仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its formula contains cinnabar, its function is to calm the nerves, but cinnabar contains mercury, which is very harmful to the human body. It is a subtle and continuous absorption process. Long-term exposure to mercury will cause chronic poisoning: Harmful to human nerves, digestion, endocrine system and kidneys; people with neurasthenia may cause symptoms such as headache, dizziness, insomnia, memory loss, and general fatigue; and long-term exposure to mercury by pregnant and breastfeeding women may also harm the fetus and baby's health
In addition, mercury-containing medicines are subject to certain restrictions when exported to other countries. For example, Singapore requires that the mercury content must be less than 0.5ppm, while the requirements for some European countries are more stringent.

Method used

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  • Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof
  • Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0135] a. Get the following weight ratio raw materials: woody 150g, agarwood 150g, citrus aurantii 150g, sandalwood 90g, rhubarb 90g, magnolia officinalis 150g, musk 4.5g, croton cream 60g, jujube 500g, chuanxiong 90g, Codonopsis 150g and Coptis 100g spare;

[0136]b. The above raw materials, croton cream and musk are crushed into fine powder for later use; woody fragrance, agarwood, citrus aurantium, sandalwood, rhubarb, magnolia, etc. are crushed, C O 2 Supercritical extraction; take the extract, add an appropriate amount of absolute ethanol to dissolve, add an appropriate amount of β-CD for clathrate, and dry to obtain the clathrate for later use; ethanol extract the dregs of the above supercritical extract twice, combine Take the filtrate twice, recover the ethanol and concentrate it for later use; take the jujube and add water to decoct it twice, and filter; combine the filtrate, concentrate, mix with the above-mentioned alcohol extract concentrate, dry, grind into fine p...

Embodiment 2

[0138] a. Take the following weight ratio raw materials: woody 600g, agarwood 600g, citrus aurantium 600g, sandalwood 360g, rhubarb 360g, magnolia bark 600g, musk 18g, croton cream 240g, jujube 2000g, chuanxiong 360g, Codonopsis 600g and Coptis chinensis 400g spare;

[0139] b. The above raw materials, croton cream and musk are crushed into fine powder for later use; woody fragrance, agarwood, citrus aurantium, sandalwood, rhubarb, magnolia bark, etc. After the inclusion of β-CD, set aside; filter the decoction, concentrate the filtrate for later use, extract the dregs and sandalwood coarse powder with ethanol for 2 times, and filter; combine the second filtrate, concentrate, dry, and set aside; take jujube, add water Decoct twice, filter; combine the second filtrate, concentrate, dry, dry and pulverize into fine powder, mix with croton cream and musk, and set aside; prepare granules according to the granule preparation method, and get ready.

Embodiment 3

[0141] a. Get the following weight ratio raw materials: woody 150g, agarwood 150g, citrus aurantii 150g, sandalwood 90g, rhubarb 90g, magnolia bark 150g, musk 4.5g, croton cream 60g, jujube 500g, chuanxiong 90g, atractylodes macrocephala 150g and Coptis 100g spare;

[0142] b. The above raw materials, croton cream and musk were crushed into fine powder; the remaining woody fragrance, agarwood, citrus aurantium, sandalwood, rhubarb, magnolia bark, etc. were decocted twice with water for 2 hours each time, and the decoction was combined and filtered , concentrated into a thick paste, add croton cream and musk powder to the above thick paste, mix well, and set aside; take an appropriate amount of polyethylene glycol 6000, heat to melt, add the above thick paste, croton cream, and musk powder mixture, mix well, Adopt the dropping speed of 85-90 drops / min, drop into the cooled liquid paraffin, and make drop pills.

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Abstract

The invention relates to a Chinese medicinal composition for treating gastrointestinal disease and a preparation method thereof. The composition is prepared from costustoot, Chinese eaglewood, bitter orange, sandalwood, rhubarb, officinal magnolia bark, musk and defatted croton seed powder in a basic prescription and other medicines, and is mainly used for treating diseases such as acute diarrhea, irritable bowel syndrome and the like clinically.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating gastrointestinal diseases and a preparation method thereof. Background technique [0002] Diarrhea can be divided into infectious and non-infectious categories. Infectious diarrhea is divided into bacterial infection and viral infection; non-infectious diarrhea can be caused by various reasons such as improper diet, food allergies, changes in life patterns, sudden changes in climate, and even emotional stress. Traditional Chinese medicine believes that diarrhea refers to increased frequency of defecation, clear and thin stool, or even watery. The main lesion of diarrhea lies in the spleen, stomach and large and small intestine. The causes of the disease include exogenous evils, injury from diet, disharmony of the seven emotions, internal resistance of dampness, and weakness of viscera. The pathogenicity of dampness seen clinically...

Claims

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Application Information

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IPC IPC(8): A61K36/835A61P1/00A61P1/12A61K35/55
CPCY02A50/30
Inventor 陈坚王磊袁学海王伟杨瑾王春晨郝忻
Owner 津药达仁堂集团股份有限公司乐仁堂制药厂
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