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Graphene oxide with antibacterial and anticoagulant functions and preparation method thereof

A graphene and anti-coagulation technology, applied in the field of graphene oxide nanomaterials, can solve problems such as restricting the application of graphene oxide, and achieve the effects of short preparation period, saving water resources, and reducing costs

Active Publication Date: 2013-05-08
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the prepared graphite oxide has problems such as how to deal with a large amount of waste acid, how to control the degree of dissociation of graphite oxide, and whether the dissociated graphene oxide sheets have biological functionality. These problems directly restrict the development of graphene oxide. Application in biomedical material matrix

Method used

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  • Graphene oxide with antibacterial and anticoagulant functions and preparation method thereof
  • Graphene oxide with antibacterial and anticoagulant functions and preparation method thereof
  • Graphene oxide with antibacterial and anticoagulant functions and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Utilize the Brodie method to prepare graphite oxide, the reaction solution does not carry out aftertreatment; Add 5% pyridine compound in the reaction solution of the prepared graphite oxide, wherein, the mass of graphite oxide and the volume ratio of pyridine compound are 1:10, adjust pH to neutral After stirring and reacting at 0°C for 1 hour, a uniform dispersion liquid is formed; the dispersion liquid is suction-filtered, washed until the filtrate is neutral, and the filter cake is dried to obtain an intermediate product of pyridine-activated graphite oxide. Dissolve the graphite oxide intermediate product activated by pyridine amines with 0.1% sodium hydroxide solution, and disperse it ultrasonically for 5 hours to obtain a homogeneous solution; filter the solution with suction, wash until the filtrate is neutral, and dry the filter cake in vacuum at 30°C for 3 days to obtain Graphene oxide with antibacterial and anticoagulant functions.

Embodiment 2

[0043] Utilize the Brodie method to prepare graphite oxide, the reaction solution is not post-treated; add 50% ammonia water to the reaction solution of the prepared graphite oxide, wherein the mass of graphite oxide and the volume ratio of the pyridine compound are 1:100, adjust the pH to neutral , after stirring and reacting at 30° C. for 5 hours, a uniform dispersion liquid was formed; the dispersion liquid was suction-filtered, washed until the filtrate was neutral, and the filter cake was dried to obtain an ammonia-activated graphite oxide intermediate product. Dissolve the ammonia-activated graphite oxide intermediate product with 5% potassium hydroxide solution, and disperse it ultrasonically for 0.5 h to obtain a homogeneous solution; filter the solution with suction, wash until the filtrate is neutral, and dry the filter cake in vacuum at 100°C for 3 h to obtain an antibacterial , Graphene oxide with anticoagulant function.

Embodiment 3

[0045] Utilize the Brodie method to prepare graphite oxide, the reaction solution is not post-treated; add 10% dimethylamine to the reaction solution of the prepared graphite oxide, wherein the mass of graphite oxide and the volume ratio of dimethylamine are 1:20, adjust the pH To neutrality, after stirring and reacting at 10°C for 2 hours, a uniform dispersion liquid is formed; the dispersion liquid is suction-filtered, washed until the filtrate is neutral, and the filter cake is dried to obtain an intermediate product of graphite oxide activated by dimethylamine. Dissolve the graphite oxide intermediate product activated by dimethylamine with 0.2% sodium hydroxide solution, and ultrasonically disperse it for 2 hours to obtain a homogeneous solution; filter the solution with suction, wash until the filtrate is neutral, and dry the filter cake in vacuum at 30°C for 2 days to obtain Graphene oxide with antibacterial and anticoagulant functions.

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Abstract

The invention discloses a method for modifying graphene oxide by controllable synthetic amination with amine based compounds and prepared graphene oxide nano material with antibacterial and anticoagulant functions. The method utilizes Brodie method, Hummers method, or Staudenmaier method to prepare graphene oxide, does not conduct post-treatment to reaction liquid, adds amine based compounds intothe reaction liquid for reaction, prepares amine activated graphene oxide intermediate product, and disperses by ultrasonic the intermediate product in alkaline solution to obtain graphene oxide withantibacterial and anticoagulant functions. The invention introduces amine based compounds into graphite oxide laminate. The amine based compounds can be acid-capturer in the reaction liquid of the synthesis process and promoter in controllable decomposition of graphite oxide laminate, and can make the prepared graphene oxide have antibacterial and anticoagulant functions.

Description

technical field [0001] The invention relates to a preparation method of modified graphene oxide and the prepared graphene oxide nanometer material, in particular to a graphene oxide with antibacterial and anticoagulant functions and a preparation method thereof. This modified graphene oxide can be used as the basic material of functionalized graphene oxide or a new type of functional filler, which can not only meet the mechanical property requirements of biomaterials, but also enable biomaterials to have long-term anticoagulant and antibacterial functions. Background technique [0002] Two-dimensional carbon materials have attracted extensive attention of researchers since their discovery, and graphene oxide, a new two-dimensional carbon material, has become a research hotspot. Compared with expensive fullerenes and carbon nanotubes, graphene oxide is cheap and its raw materials are readily available. The surface of graphite oxide is rich in a large number of oxygen functio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B31/04
Inventor 周宁琳徐东
Owner NANJING NORMAL UNIVERSITY
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