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Method for determining Nevirapine by utilizing ZnS nano fluorescence probe

A nano-fluorescent probe, nevirapine technology, applied in the field of optical analysis and detection, can solve problems that have not been reported, and achieve the effect of optimizing test conditions

Inactive Publication Date: 2012-05-02
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently, the assay methods for nevirapine are: gas chromatography, high performance liquid chromatography-UV method, high performance liquid chromatography tandem mass spectrometry, micellar electrokinetic chromatography, capillary zone electrophoresis, etc. Drug method has not been reported yet

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  • Method for determining Nevirapine by utilizing ZnS nano fluorescence probe
  • Method for determining Nevirapine by utilizing ZnS nano fluorescence probe
  • Method for determining Nevirapine by utilizing ZnS nano fluorescence probe

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Embodiment Construction

[0014] Specific embodiments of the present invention are described below.

[0015] Utilize the ZnS nano fluorescent probe modified in the present embodiment to measure the steps of nevirapine as follows:

[0016] A. Preparation of ZnS nanoparticles: Accurately weigh 0.7161 g of zinc powder and 0.1172 g of sulfur powder (molar ratio 3:1), put them together into the lining of a 30 ml polytetrafluoroethylene autoclave, and then add 25 ml of prepared 3 M NaOH solution; sealed and placed in an oven at 180°C for 24 h. After the reaction is completed, close the oven, wait for the PTFE high-pressure container to cool down to room temperature naturally; absorb the upper clear night, pour the bottom product of the inner substrate into a beaker, add deionized water for ultrasonication, centrifuge, wash, and then use absolute ethanol instead of deionized water for ultrasonication , centrifuge, and wash several times until no solid particles remain at the bottom of the beaker after ultras...

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Abstract

The invention relates to a method for rapidly determining Nevirapine by utilizing mercaptoacetic-acid-modified ZnS nano particles as a nano fluorescence probe, and belongs to the technical field of optical analysis detection. In the method provided by the invention, a principle that the fluorescence intensity changes after the ZnS nano fluorescence probe interacts with Nevirapine to be determinedis mainly utilized, thus sensitive and quantitative analysis and determination are carried out on the Nevirapine through spectrofluorimetry. In the method provided by the invention, by optimizing experiment conditions such as temperature, addition sequence, pH value and reaction time, the fluorescence probe is applied to quantitative detection of the Nevirapine in optimal conditions. The determination process provided by the invention has the characteristics of simpleness, rapidness, sensitivity, accuracy and the like.

Description

technical field [0001] The invention relates to a method for measuring nevirapine by using semiconductor nanometer material zinc sulfide as a fluorescent probe, belonging to the technical field of optical analysis and detection. Background technique [0002] As an important research object of nanotechnology, nanomaterials are an important direction in modern scientific research. The quantum confinement effect makes nanomaterials have many exotic properties compared with macroscopic bulk materials, such as surface effect, quantum size effect and macroscopic tunnel effect. Affected by these effects, nanoparticles exhibit specific optical, electrical, magnetic, thermal, mechanical, mechanical and other properties that are different from bulk substances. Using their special luminescent properties, people can use them as nano-fluorescence probes , applied to various fields. Compared with traditional organic fluorescent dyes, nanofluorescent probes have more superior properties,...

Claims

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Application Information

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IPC IPC(8): G01N21/64C09K11/56
Inventor 丁亚平程瑜李丽陆雅翔罗立强
Owner SHANGHAI UNIV
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