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Separation and purification process of glycyrrhizic acid

A technology for separation and purification of glycyrrhizic acid, applied in the field of medicine and chemical industry, can solve the problems of low product purity and narrowed application scope, and achieve the effects of reducing process cost, improving selectivity and increasing value

Inactive Publication Date: 2012-05-16
曾科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The present invention aims to solve the problem that the purity of the product obtained by the above method is not high and the scope of application is narrowed, and provides a separation and purification process of glycyrrhizic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Separation and Purification of Glycyrrhizic Acid

[0022] A. Boiling extraction process: add 3 times the weight of distilled water to the licorice tablet, boil for 50 minutes and filter out the boiling liquid, and use distilled water to carry out boiling and extraction of the filter residue twice; combine the boiling liquid, concentrate at 30°C, slowly Add 1 mol / l hydrochloric acid to adjust the pH value to 4.5. After standing for 5 hours, filter, wash the solid precipitate to neutrality, grind it into 100 mesh powder, and obtain coarse glycyrrhizic acid powder.

[0023] B. Ethanol extraction process: boiling and extracting the crude glycyrrhizic acid powder, using 3 times the mass of ethanol with a volume concentration of 90%, refluxing 4 times at 55° C. for 30 minutes each time to obtain crude glycyrrhizic acid.

[0024] C. Macroporous adsorption resin chromatography and elution process: the glycyrrhizic acid crude product obtained by ethanol extraction is dissolved i...

Embodiment 2

[0027] Separation and Purification of Glycyrrhizic Acid

[0028] A. Boiling extraction process: add 5 times the weight of distilled water to the licorice tablet, boil for 20 minutes and filter out the boiling liquid, and carry out 2 boiling extractions on the filter residue with distilled water; combine the boiling liquid, concentrate at 30 ° C, slowly Add 1 mol / l hydrochloric acid to adjust the pH value to 2; filter after standing for 2 hours, wash the solid precipitate to neutrality, grind it into 100 mesh powder, and obtain coarse glycyrrhizic acid powder.

[0029] B. Ethanol extraction process: Boil and extract the crude glycyrrhizic acid powder obtained by boiling and extracting, use twice the mass of ethanol with a volume concentration of 75%, and reflux 2-4 times at 35° C. for 30 minutes each time to obtain crude glycyrrhizic acid.

[0030] C. Macroporous adsorption resin chromatography and elution process: the glycyrrhizic acid crude product obtained by ethanol extract...

Embodiment 3

[0033] Separation and Purification of Glycyrrhizic Acid

[0034] A, boiling extraction process: add 5 times the weight of distilled water to the licorice tablet, boil for 50 minutes and filter out the boiling liquid, and carry out boiling extraction for the filter residue with distilled water for 4 times; combine the boiling liquid, concentrate at 80°C, slowly Add 1 mol / l hydrochloric acid to adjust the pH value to 4.5. After standing for 5 hours, filter, wash the solid precipitate to neutrality, grind it into 200 mesh powder, and obtain coarse glycyrrhizic acid powder.

[0035] B. Ethanol extraction process: boiling and extracting the crude glycyrrhizic acid powder with 3 times the mass and 90% volume concentration of ethanol to reflux 4 times at 55° C. for 50 minutes each time to obtain crude glycyrrhizic acid.

[0036] C. Macroporous adsorption resin chromatography and elution process: the glycyrrhizic acid crude product obtained by ethanol extraction is dissolved in water,...

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PUM

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Abstract

The invention relates to a separation and purification process of glycyrrhizic acid, belonging to the field of pharmaceutical and chemical industry. The method provided by the invention comprises the following steps: hot water extraction, ethanol extraction, macroporous adsorption resin chromatography and elution, and ion-exchange resin chromatography. Because the ion-exchange resin chromatography step is added to the scheme of the invention, the selectivity is greatly improved, so that the purity of the finally obtained product is nearly 99%. The method can be used for preparing medicines and even injections, thereby enlarging the range of application, improving the value of products and lowering the process cost.

Description

technical field [0001] The invention relates to a separation and purification process, more specifically, the invention relates to a separation and purification process of glycyrrhizic acid, which belongs to the field of medicine and chemical industry. Background technique [0002] Licorice (medicinal name: Radix Glycyrrhiza), is a tonic Chinese herbal medicine. The medicinal parts are roots and rhizomes. The roots are cylindrical, 25-100cm long, and 0.6-3.5cm in diameter. The outer skin is of different tightness, and the surface is reddish brown or grayish brown. The rhizome is cylindrical, with bud scars on the surface and pith in the middle of the section. The smell is slightly sweet and special. Function cures mainly heat-clearing and toxic substances removing, eliminating phlegm and relieving cough, gastral cavity etc. It likes a dry climate with plenty of sunshine, long sunshine and low temperature. Licorice mostly grows in arid and semi-arid desert steppes, deser...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/08
Inventor 曾科
Owner 曾科
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